公开(公告)号：US20030032772A1

公开(公告)日：2003-02-13

申请号：US09952267

申请日：2001-09-12

Applicant: The Board of Regents, University of Texas System

Inventor： Eric J. Hansen ,  Christoph Aebi ,  Leslie D. Cope ,  Isobel Maciver ,  Michael J. Fiske ,  Ross A. Fredenburg

IPC: C07K014/435

CPC classification number: C07K14/212 ,  A61K39/00 ,  C07K16/1217

Abstract: The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

Abstract translation: 本发明公开了两种新型蛋白质UspA1和UspA2及其各自的基因uspA1和uspA2的存在。 每个蛋白质包含在两种蛋白质之间保守的区域，并且包含由MAb 17C7识别的表位。 这些物质中的一种或多于一种可能聚集形成UspA抗原的非常高分子量形式（即大于200kDa）。 公开了组合物以及用于治疗和研究卡他莫拉菌的诊断和治疗方法。

公开(公告)号：US20210016266A1

公开(公告)日：2021-01-21

申请号：US17022304

申请日：2020-09-16

Applicant: THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  DIONEX CORPORATION

Inventor： Purnendu K. DASGUPTA ,  Weixiong HUANG ,  Christopher A. POHL

IPC: B01J39/26 ,  G01N30/60 ,  B01J20/32 ,  B01J20/286 ,  B01D15/36 ,  B01D15/20 ,  B01D15/22 ,  B01J41/20 ,  B01J47/02

Abstract: Open tubular capillary columns for liquid and ion chromatography, based upon an ionically impermeable polyolefin capillary having a bore with a sulfonate-group- or amine-group-functionalized internal surface. The capillary columns may include a coating of ion exchanging nanoparticles electrostatically bound to the functionalized internal surface. The capillary columns may be made by exposing the interior surface to a sulfonating reagent comprising chlorosulfonic acid (CISO3H), preferably from 85 wt % to 95 wt % chlorosulfonic acid at a process temperature of 20 to 25° C. The interior surface may be subsequently exposed to an asymmetrical diamine to form a sulfonic mid-linkage to the diamine, i.e., to form a sulfonamide-linked, amine-group-functionalized internal surface. The coating may be provided by subsequently exposing the interior surface to an aqueous suspension of ion exchanging nanoparticles to electrostatically bond the ion exchanging nanoparticles to the functionalized internal surface.

公开(公告)号：US09353094B2

公开(公告)日：2016-05-31

申请号：US14639501

申请日：2015-03-05

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： Amarnath Natarajan ,  Qianyi Chen ,  Vashti C. Bryant ,  Rajkumar Rajule

IPC: C07D241/44 ,  C07D409/14 ,  C07D241/42 ,  C07D405/04 ,  C07D405/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04

CPC classification number: C07D409/14 ,  C07D241/42 ,  C07D241/44 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/14 ,  C07D471/04

Abstract: Disclosed herein are compounds of formula (I) and methods of inhibiting IKKβ and the NF-κB signaling and mTOR pathways.

Abstract translation: 本文公开了式（I）的化合物和抑制IKK和bgr的方法; 和NF-κB信号通路和mTOR通路。

公开(公告)号：US20020052332A1

公开(公告)日：2002-05-02

申请号：US09832611

申请日：2001-04-11

Applicant: The Board of Regents, University of Texas System

Inventor： Bernard F. Godley

IPC: A61K031/70 ,  A01N043/04 ,  C12P021/06 ,  C12N015/00 ,  C12N015/09 ,  C12N015/63 ,  C12N015/70 ,  C12N015/74

CPC classification number: C12N9/1088 ,  A61K31/70 ,  A61K48/00

Abstract: The present invention provides methods for inhibiting the degeneration of retinal pigment epithelial cells, which can reduce the incidence of, or delay the onset of, age-related macular degeneration, particularly in the early stages of AMD or in individuals at high risk for the disease.

Abstract translation: 本发明提供抑制视网膜色素上皮细胞变性的方法，其可以降低年龄相关性黄斑变性的发生率或延迟发作，特别是在AMD的早期阶段或患有该疾病的高风险个体中 。

公开(公告)号：US20020041874A1

公开(公告)日：2002-04-11

申请号：US09943659

申请日：2001-08-31

Applicant: The Board of Regents, University of Texas System

Inventor： Gregory R. Mundy ,  Toshiyuki Yoneda

IPC: A61K039/395

CPC classification number: C07K14/70542 ,  A61K38/00 ,  C07K16/2836 ,  C07K16/2839 ,  C07K16/2842

Abstract: Antagonists of null4 integrin/null4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their null4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.

Abstract translation: 描述了抑制这种粘附的生物学作用的α4整联蛋白/α4整联蛋白配体粘附的拮抗剂，并详细说明了其使用方法。 这样的拮抗剂可用于抑制与多发性骨髓瘤相关的骨破坏。 多发性骨髓瘤细胞归巢到骨髓及其α4整联蛋白依赖性释放的骨吸收因子，导致多发性骨髓瘤患者骨质破坏。

公开(公告)号：US20210335117A1

公开(公告)日：2021-10-28

申请号：US17232391

申请日：2021-04-16

Applicant: Colorado State University Research Foundation ,  The Board of Regents, University of Texas System

Inventor： Gerald Patrick Duggan ,  Kathleen Maron Smits ,  Riley DeWitt Ancona ,  Younki Cho

IPC: G08B21/16 ,  G08B25/08 ,  G01M3/18 ,  G01S19/01

Abstract: Gas monitoring network and deployment systems and methods are described for detecting gas leaks (e.g., natural gas leaks) from gas infrastructures (e.g., buried natural gas) within residential, commercial, rural, and industrial areas. A method of deployment involves placing detector systems indoor and outdoor environments in distinct patterns, providing early warning or long-term monitoring of gas leaks via data communication technologies.