公开(公告)号：US06595388B2

公开(公告)日：2003-07-22

申请号：US10184966

申请日：2002-07-01

申请人： Yoichiro Mizutani ,  Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

发明人： Yoichiro Mizutani ,  Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

IPC分类号： G01F1106

CPC分类号： A61B17/8822 ,  A61B2050/0066 ,  A61B2050/3015 ,  A61F2002/30617 ,  A61F2250/0097 ,  A61M5/31551 ,  A61M5/31561 ,  A61M5/31571 ,  A61M5/3158 ,  A61M5/31586 ,  A61M5/31591 ,  B01F11/0082 ,  B01F13/002 ,  B01F15/0279 ,  B01F2215/0029

摘要： An assisting tool for pressing a piston while fixing in place a syringe or a similar instrument which contains a highly viscous chemical agent, so as to extrude the chemical agent, as well as a method for extruding a chemical agent using the same. The chemical-agent extrusion assisting-tool includes a tool body in the form of a cylindrical body having a space formed therein for accommodating a tubular container, such as a syringe, which contains a highly viscous chemical, such as calcium-phosphate-based cement formed by kneading a calcium phosphate powder and a kneading liquid composed of a polysaccharide-containing aqueous solution, and an outlet formed at its bottom end. The cylindrical body has a cylindrical space formed therein so as to open at an upper end surface thereof. The assisting-tool further has a pusher including a handle portion for pressing a piston to be inserted into the tubular container, and a tubular body screw-threadedly engaged with the tool body and disposed on a side of the handle portion which presses the piston. The handle portion of the chemical-agent extrusion assisting-tool is rotated so as to press the tubular body into the cylindrical space and so as to press the piston into the tubular container, thereby extruding the chemical agent from the tubular container.

摘要翻译： 一种固定在适当位置的活塞的辅助工具，同时固定含有高粘度化学试剂的注射器或类似仪器，以挤出化学试剂，以及使用该活化剂的化学试剂的挤出方法。 化学试剂挤出辅助工具包括具有形成在其中的空间形式的圆柱体形式的工具主体，用于容纳诸如注射器的管状容器，其包含高粘度化学品，例如磷酸钙基水泥 通过捏合磷酸钙粉末和由含多糖水溶液组成的捏合液形成，以及在其底端形成的出口。 圆筒体具有形成在其中的圆柱形空间，以便在其上端面处开口。 辅助工具还具有推动器，其包括用于按压插入到管状容器中的活塞的把手部分和与工具主体螺纹接合并设置在压紧活塞的手柄部分的一侧的管状体。 旋转化学试剂挤压辅助工具的手柄部分，以将管状体压入圆柱形空间中，以将活塞压入管状容器中，从而从管状容器挤出化学试剂。

公开(公告)号：US09931438B2

公开(公告)日：2018-04-03

申请号：US12864781

申请日：2008-09-29

申请人： Shinjiro Kasahara ,  Takenori Sawamura

发明人： Shinjiro Kasahara ,  Takenori Sawamura

IPC分类号： A61L27/56 ,  A61L27/14 ,  A61L27/18 ,  A61L27/44

CPC分类号： A61L27/56 ,  A61L27/14 ,  A61L27/18 ,  A61L27/44 ,  C08L71/00

摘要： The objection of this invention is to provide an article with a foamed surface having a porous structure in the surface of a plastic base, an implant and a method of producing them. The article has a body and a superficial layer formed in a surface of the body, the layer including small-diameter and large-diameter pores, wherein part of the small-diameter and large-diameter pores are open pores which are open at the surface of the layer; the open pores have small open pores with an average diameter of 5 μm or less and large open pores with an average diameter from 10 to 200 μm; and the large open pores have an inner wall with passages connected with the small-diameter large-diameter pores. The implant is the article itself or the article with a bioactive substance in the layer thereof. The method provides an example of producing the article and implant.

公开(公告)号：US5980625A

公开(公告)日：1999-11-09

申请号：US41390

申请日：1998-03-12

申请人： Takenori Sawamura ,  Masateru Hattori

发明人： Takenori Sawamura ,  Masateru Hattori

IPC分类号： A61L24/00 ,  A61K6/033 ,  A61K6/097 ,  A61L27/00 ,  C04B28/34 ,  C08L5/06 ,  C04B12/02 ,  A61C13/00 ,  A61F2/02

CPC分类号： C04B28/34 ,  C08L5/06 ,  C04B2111/00112 ,  C04B2111/00836 ,  C04B2201/10

摘要： The present invention provides a setting solution for calcium phosphate cement as well as a calcium phosphate cement composition. The setting solution does not cause disintegration of the composition when the composition is used immediately after preparation. The content of the pectin in the setting solution is 0.5-10% by weight per 100% by weight of the solution. The setting solution has a pH of 3-5, and a viscosity of not more than 200 dPa.multidot.s. The calcium phosphate may be selected from the group consisting of tetracalcium phosphate, calcium hydrogen phosphate, tricalcium .alpha.-phosphate, tricalcium .beta.-phosphate, and hydroxyapatite.

摘要翻译： 本发明提供了一种磷酸钙水泥和磷酸钙水泥组合物的固化溶液。 当制备后立即使用组合物时，固化溶液不会使组合物崩解。 凝固溶液中果胶的含量为每100重量％溶液0.5-10重量％。 固化溶液的pH值为3-5，粘度不超过200 dPax。 磷酸钙可以选自磷酸四钙，磷酸氢钙，磷酸三钙，磷酸三钙和羟基磷灰石。

公开(公告)号：US08071496B2

公开(公告)日：2011-12-06

申请号：US12616514

申请日：2009-11-11

申请人： Yasushi Hara ,  Tetsuya Maeda ,  Akifumi Tosa ,  Takenori Sawamura

发明人： Yasushi Hara ,  Tetsuya Maeda ,  Akifumi Tosa ,  Takenori Sawamura

IPC分类号： C04B35/587 ,  G01R31/26

CPC分类号： G01R31/2886 ,  C04B35/593 ,  C04B35/5935 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3217 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3229 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/77 ,  C04B2235/85

摘要： A silicon nitride-melilite composite sintered body in accordance with the invention includes silicon nitride and a melilite Me2Si3O3N4, where Me denotes a metal element combining with silicon nitride to generate the melilite. The silicon nitride-melilite composite sintered body contains Si in a range of 41 to 83 mole percent in Si3N4 equivalent and Me in a range of 13 to 50 mole percent in oxide equivalent. The silicon nitride-melilite composite sintered body has an average thermal expansion coefficient that is arbitrarily adjustable in a range of 2 to 6 ppm/K at temperatures of 23 to 150° C. The silicon nitride-melilite composite sintered body has a high Young's modulus, a high mechanical strength, and excellent sintering performance. A device used for inspection of semiconductor in accordance with the invention utilizes such a silicon nitride-melilite composite sintered body.

摘要翻译： 根据本发明的氮化硅 - 辉石复合烧结体包括氮化硅和Meliteite Me2Si3O3N4，其中Me表示与氮化硅结合以产生melilite的金属元素。 氮化硅 - 辉石复合烧结体的Si 3 N 4当量中Si为41〜83摩尔％，Me为氧化物当量的13〜50摩尔％。 氮化硅 - 辉石复合烧结体的平均热膨胀系数在23〜150℃的温度范围内可以在2〜6ppm / K的范围内任意调整。氮化硅 - 辉石复合烧结体的杨氏模量高 ，机械强度高，烧结性能优异。 根据本发明的用于半导体检查的装置利用这种氮化硅 - 辉石复合烧结体。

公开(公告)号：US20110022181A1

公开(公告)日：2011-01-27

申请号：US12864781

申请日：2008-09-29

申请人： Shinjiro Kasahara ,  Takenori Sawamura

发明人： Shinjiro Kasahara ,  Takenori Sawamura

IPC分类号： A61F2/28 ,  B29C44/06

CPC分类号： A61L27/56 ,  A61L27/14 ,  A61L27/18 ,  A61L27/44 ,  C08L71/00

摘要： The objection of this invention is to provide an article with a foamed surface having a porous structure in the surface of a plastic base, an implant and a method of producing them. The article has a body and a superficial layer formed in a surface of the body, the layer including small-diameter and large-diameter pores, wherein part of the small-diameter and large-diameter pores are open pores which are open at the surface of the layer; the open pores have small open pores with an average diameter of 5 μm or less and large open pores with an average diameter from 10 to 200 μm; and the large open pores have an inner wall with passages connected with the small-diameter large-diameter pores. The implant is the article itself or the article with a bioactive substance in the layer thereof. The method provides an example of producing the article and implant.

摘要翻译： 本发明的目的是提供一种具有在塑料基材表面上具有多孔结构的泡沫表面的制品，植入物及其制造方法。 该制品具有形成在主体表面的主体和表层，该层包括小直径和大直径孔，其中部分小直径和大直径孔是在表面开口的开孔 的层; 开孔具有平均直径为5μm以下的小开孔，平均直径为10〜200μm的大开孔; 大的开放孔具有内壁，通孔与小直径的大直径孔连通。 植入物是其本身或其层中具有生物活性物质的制品。 该方法提供了制造物品和植入物的实例。

公开(公告)号：US06550957B2

公开(公告)日：2003-04-22

申请号：US10079568

申请日：2002-02-22

申请人： Yoichiro Mizutani ,  Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

发明人： Yoichiro Mizutani ,  Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

IPC分类号： A61C506

CPC分类号： B01F11/0054 ,  A61B17/8822 ,  A61B17/8825 ,  A61B2017/8838 ,  A61B2050/0066 ,  B01F7/00291 ,  B01F13/002 ,  B01F15/00506 ,  B01F15/00681 ,  B01F15/0279 ,  B01F2215/0029

摘要： A kneading device adapted for preparing calcium phosphate-based cement and for applying the cement directly to a required site which comprises a cylinder 1 which includes a hollow cylindrical body portion 11 and a nozzle 12 formed at the distal end of the cylindrical body portion; a plug 2 having an axial through-hole 21 slidably disposed within the proximal end of the cylindrical body portion; a piston assembly 3 which includes a shaft 31 extending through the through-hole 21 of the plug 2 for axial and rotatable movement, a kneading element 32 at the distal end of the shaft 31 within the cylindrical body portion, and a handle 34 formed at the proximal end of the shaft 31 external of the cylindrical body portion; a cover member 4 attached to and forming a closure for the nozzle 12; and a stop member 5 for locating the plug 2 in position at the proximal end of the cylindrical body portion.

公开(公告)号：US06431743B1

公开(公告)日：2002-08-13

申请号：US09678399

申请日：2000-10-03

申请人： Yoichiro Mizutani ,  Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

发明人： Yoichiro Mizutani ,  Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

IPC分类号： B01F1502

CPC分类号： A61B17/8822 ,  A61B2050/0066 ,  A61B2050/3015 ,  A61F2002/30617 ,  A61F2250/0097 ,  A61M5/31551 ,  A61M5/31561 ,  A61M5/31571 ,  A61M5/3158 ,  A61M5/31586 ,  A61M5/31591 ,  B01F11/0082 ,  B01F13/002 ,  B01F15/0279 ,  B01F2215/0029

摘要： An assisting tool for pressing a piston while fixing in place a syringe or a similar instrument which contains a highly viscous chemical agent, so as to extrude the chemical agent, as well as a method for extruding a chemical agent using the same. The chemical-agent extrusion assisting-tool includes a tool body in the form of a cylindrical body having a space formed therein for accommodating a tubular container, such as a syringe, which contains a highly viscous chemical, such as calcium-phosphate-based cement formed by kneading a calcium phosphate powder and a kneading liquid composed of a polysaccharide-containing aqueous solution, and an outlet formed at its bottom end. The cylindrical body has a cylindrical space formed therein so as to open at an upper end surface thereof. The assisting-tool further has a pusher including a handle portion for pressing a piston to be inserted into the tubular container, and a tubular body screw-threadedly engaged with the tool body and disposed on a side of the handle portion which presses the piston. The handle portion of the chemical-agent extrusion assisting-tool is rotated so as to press the tubular body into the cylindrical space and so as to press the piston into the tubular container, thereby extruding the chemical agent from the tubular container.

摘要翻译： 一种固定在适当位置的活塞的辅助工具，同时固定含有高粘度化学试剂的注射器或类似仪器，以挤出化学试剂，以及使用该活化剂的化学试剂的挤出方法。 化学试剂挤出辅助工具包括具有形成在其中的空间形式的圆柱体形式的工具主体，用于容纳诸如注射器的管状容器，其包含高粘度化学品，例如磷酸钙基水泥 通过捏合磷酸钙粉末和由含多糖水溶液组成的捏合液形成，以及在其底端形成的出口。 圆筒体具有形成在其中的圆柱形空间，以便在其上端面处开口。 辅助工具还具有推动器，其包括用于按压插入到管状容器中的活塞的把手部分和与工具主体螺纹接合并设置在压紧活塞的手柄部分的一侧的管状体。 旋转化学试剂挤压辅助工具的手柄部分，以将管状体压入圆柱形空间中，以将活塞压入管状容器中，从而从管状容器挤出化学试剂。

公开(公告)号：US06367962B1

公开(公告)日：2002-04-09

申请号：US09595903

申请日：2000-06-20

申请人： Yoichiro Mizutani ,  Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

发明人： Yoichiro Mizutani ,  Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

IPC分类号： A61C506

CPC分类号： B01F11/0054 ,  A61B17/8822 ,  A61B2050/0066 ,  B01F7/00291 ,  B01F13/002 ,  B01F15/00506 ,  B01F15/00681 ,  B01F15/0279 ,  B01F2215/0029

摘要： A kneading device adapted for preparing calcium phosphate-based cement and for applying the cement directly to a required site which comprises a cylinder 1 which includes a hollow cylindrical body portion 11 and a nozzle 12 formed at the distal end of the cylindrical body portion; a plug 2 having an axial through-hole 21 slidably disposed within the proximal end of the cylindrical body portion; a piston assembly 3 which includes a shaft 31 extending through the through-hole 21 of the plug 2 for axial and rotatable movement, a kneading element 32 at the distal end of the shaft 31 within the cylindrical body portion, and a handle 34 formed at the proximal end of the shaft 31 external of the cylindrical body portion; a cover member 4 attached to and forming a closure for the nozzle 12; and a stop member 5 for locating the plug 2 in position at the proximal end of the cylindrical body portion.

摘要翻译： 一种适于制备磷酸钙基水泥和用于将水泥直接施加到所需位置的捏合装置，其包括圆柱体1，圆柱体1包括形成在圆柱形主体部分的远端处的中空圆柱形主体部分11和喷嘴12; 插头2，其具有可滑动地设置在圆筒体部分的近端内的轴向通孔21; 活塞组件3，其包括延伸穿过用于轴向和可旋转运动的塞子2的通孔21的轴31，在圆筒体部分内的轴31的远端处的捏合元件32和形成在 轴31的近端在圆筒体部分的外部; 附接到并形成用于喷嘴12的封闭件的盖构件4; 以及用于将插头2定位在圆柱形主体部分的近端的适当位置的止动构件5。

公开(公告)号：US5993535A

公开(公告)日：1999-11-30

申请号：US141516

申请日：1998-08-27

申请人： Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

发明人： Takenori Sawamura ,  Masateru Hattori ,  Masahiko Okuyama

IPC分类号： A61F2/00 ,  A61K6/033 ,  A61K6/097 ,  A61L24/02 ,  A61L27/12 ,  C04B28/34 ,  C04B12/02 ,  C04B24/38

CPC分类号： A61K6/033 ,  A61K6/0643 ,  A61K6/097 ,  A61L24/02 ,  A61L27/12 ,  C04B28/344 ,  A61F2310/00293 ,  C04B2111/00836

摘要： A calcium phosphate cement and a calcium phosphate cement composition are disclosed. The calcium phosphate cement comprises a calcium phosphate powder having an average particle diameter of 20 .mu.m or smaller and a tap density of 35% or higher, and a polysaccharide. The polysaccharide is preferably a dextran sulfate (e.g., dextran sulfate sodium) having an average particle diameter of 0.1 to 100 .mu.m. The calcium phosphate cement composition comprises the above specific calcium phosphate powder and a liquid for cement mixing comprising an aqueous solution containing 30 to 60 wt % dextran sulfate (e.g., dextran sulfate sodium or dextran sulfate potassium). The calcium phosphate powder preferably comprises a tetracalcium phosphate powder and an equimolar amount of a calcium hydrogen phosphate powder as main components.

摘要翻译： 公开了磷酸钙水泥和磷酸钙水泥组合物。 磷酸钙水泥包含平均粒径为20μm以下且振实密度为35％以上的磷酸钙粉末和多糖。 多糖优选为平均粒径为0.1〜100μm的硫酸葡聚糖（例如硫酸葡聚糖钠）。 磷酸钙水泥组合物包含上述特定的磷酸钙粉末和用于水泥混合的液体，其包含含有30-60wt％硫酸葡聚糖的水溶液（例如硫酸葡聚糖钠或硫酸葡聚糖钾）。 磷酸钙粉末优选包含磷酸四钙粉末和等摩尔量的磷酸氢钙粉末作为主要成分。

公开(公告)号：US20100130345A1

公开(公告)日：2010-05-27

申请号：US12616514

申请日：2009-11-11

申请人： Yasushi HARA ,  Tetsuya Maeda ,  Akifumi Tosa ,  Takenori Sawamura

发明人： Yasushi HARA ,  Tetsuya Maeda ,  Akifumi Tosa ,  Takenori Sawamura

IPC分类号： C04B35/584 ,  G01R31/02 ,  G01R31/26

CPC分类号： G01R31/2886 ,  C04B35/593 ,  C04B35/5935 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3217 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3229 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/77 ,  C04B2235/85

摘要： A silicon nitride-melilite composite sintered body in accordance with the invention includes silicon nitride and a melilite Me2Si3O3N4, where Me denotes a metal element combining with silicon nitride to generate the melilite. The silicon nitride-melilite composite sintered body contains Si in a range of 41 to 83 mole percent in Si3N4 equivalent and Me in a range of 13 to 50 mole percent in oxide equivalent. The silicon nitride-melilite composite sintered body has an average thermal expansion coefficient that is arbitrarily adjustable in a range of 2 to 6 ppm/K at temperatures of 23 to 150° C. The silicon nitride-melilite composite sintered body has a high Young's modulus, a high mechanical strength, and excellent sintering performance. A device used for inspection of semiconductor in accordance with the invention utilizes such a silicon nitride-melilite composite sintered body.

摘要翻译： 根据本发明的氮化硅 - 辉石复合烧结体包括氮化硅和Meliteite Me2Si3O3N4，其中Me表示与氮化硅结合以产生melilite的金属元素。 氮化硅 - 辉石复合烧结体的Si 3 N 4当量中Si为41〜83摩尔％，Me为氧化物当量的13〜50摩尔％。 氮化硅 - 辉石复合烧结体的平均热膨胀系数在23〜150℃的温度范围内可以在2〜6ppm / K的范围内任意调整。氮化硅 - 辉石复合烧结体的杨氏模量高 ，机械强度高，烧结性能优异。 根据本发明的用于半导体检查的装置利用这种氮化硅 - 辉石复合烧结体。