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    Urea stabilized with a lactone in various pharmaceutical and cosmetic preparations
    1.
    发明授权
    Urea stabilized with a lactone in various pharmaceutical and cosmetic preparations 失效
    尿素在各种药物和化妆品制剂中用内酯稳定

    公开(公告)号：US4672078A

    公开(公告)日：1987-06-09

    申请号：US752263

    申请日：1985-07-03

    申请人： Kirk Sakai ,  Timothy W. Quick

    发明人： Kirk Sakai ,  Timothy W. Quick

    IPC分类号： A61K8/49 ,  A61K9/00 ,  A61K31/17 ,  A61K31/365 ,  A61K45/06 ,  A61K47/22 ,  A61Q19/00 ,  A61K47/00

    CPC分类号： A61K9/0014 ,  A61K31/17 ,  A61K31/365 ,  A61K47/22 ,  A61K8/42 ,  A61K8/4973 ,  A61K8/498 ,  A61Q19/00 ,  Y10S514/97

    摘要： A pharmaceutical preparation containing 1 to 50% urea and 0.05 to 30% of a lactone is disclosed. A preferred lactone is gamma-butyrolactone which is preferably present in an amount of about 0.05 to 0.1 part by weight per 1 part by weight of urea. The lactone stabilizes the urea with respect to various parameters including changes in pH. The pharmaceutical preparation may be any preparation with stabilized urea such as a skin lotion or cream used to moisturize skin, or a post surgical preparation because urea aids in debridement, dissolves coagulum and promotes epithelialization. Alternatively the preparation may be an injectable solution used in the treatment for mobilization of edema fluid, as urea is used for an osmotic diuretic.

    摘要翻译： 公开了含有1〜50％尿素和0.05〜30％内酯的药物制剂。 优选的内酯是γ-丁内酯，其优选以每1重量份尿素约0.05至0.1重量份的量存在。 内酯相对于包括pH变化在内的各种参数稳定尿素。 药物制剂可以是具有稳定的尿素的任何制剂，例如用于润湿皮肤的皮肤洗剂或霜剂，或者后手术制剂，因为尿素有助于清创，溶解凝结物并促进上皮形成。 或者，制剂可以是用于动员水肿液的治疗中的可注射溶液，因为尿素用于渗透利尿剂。