公开(公告)号：US20240156365A1

公开(公告)日：2024-05-16

申请号：US18548788

申请日：2022-02-23

Applicant: TURUN YLIOPISTO

Inventor： Matti KAISTI ,  Tuukka PANULA ,  Jukka-Pekka SIRKIÄ

IPC: A61B5/026 ,  A61B5/02 ,  A61B5/022 ,  A61B5/024

CPC classification number: A61B5/0261 ,  A61B5/02007 ,  A61B5/02241 ,  A61B5/02416

Abstract: An apparatus for measuring flow resistances of blood vessels includes a photoplethysmography sensor for emitting electromagnetic radiation with different wavelengths to the blood vessels, a pressure instrument for applying controllable mechanical pressure on the blood vessels, and a control system for estimating compliances of the blood vessels based on electromagnetic radiation reflected off the blood vessels. Shorter wavelengths of the electromagnetic radiation are reflected off smaller blood vessels than longer wavelengths. The control system optimizes resistor values of a circuit model to minimize differences between waveforms of node voltages of the circuit model and waveforms of measured blood pressures prevailing in blood vessels reflecting off different wavelengths. Capacitor values of the circuit model are based on the estimated compliances of the blood vessels, and the optimized resistor values of the circuit model are indicative of the flow resistances of the blood vessels.

公开(公告)号：US20240130626A1

公开(公告)日：2024-04-25

申请号：US18547970

申请日：2022-02-22

Applicant: TURUN YLIOPISTO

Inventor： Matti KAISTI ,  Tuukka PANULA ,  Jukka-Pekka SIRKIÄ

IPC: A61B5/0225 ,  A61B5/00 ,  A61B5/02 ,  A61B5/022

CPC classification number: A61B5/02255 ,  A61B5/02007 ,  A61B5/02241 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/7235 ,  A61B5/7271 ,  A61B2560/0462 ,  A61B2562/0233

Abstract: An apparatus for measuring compliance of blood vessels includes a photoplethysmography sensor for emitting electromagnetic radiation to the blood vessels, for receiving electromagnetic radiation reflected off the blood vessels, and for producing a measurement signal indicative of the received electromagnetic radiation. The apparatus further includes a pressure instrument for producing mechanical pressure applied on the blood vessels, and a control system for controlling the pressure instrument to change the mechanical pressure linearly with respect to time during emission of electromagnetic radiation to the blood vessels and reception of reflected electromagnetic radiation from the blood vessels. The control system finds, from the measurement signal, a portion whose envelope has exponential change with respect to time and produces an estimate for an exponent coefficient of time during the exponential change. The coefficient is indicative of the compliance, as well as stiffness, of the blood vessels.

公开(公告)号：US20240117217A1

公开(公告)日：2024-04-11

申请号：US18530431

申请日：2023-12-06

Applicant: Turun Yliopisto

Inventor： Carita KVARNSTRÖM ,  Pia DAMLIN ,  Mikko SALOMÄKI ,  Mauri NAUMA ,  Rahul Balu YEWALE

IPC: C09D181/02 ,  B05D1/00 ,  B05D3/10 ,  C08G61/12 ,  C08J5/18 ,  C08J7/04 ,  C08J7/16 ,  C09D5/24 ,  C09D7/63 ,  H01B1/12

CPC classification number: C09D181/02 ,  B05D1/005 ,  B05D1/60 ,  B05D3/101 ,  B05D3/104 ,  B05D3/108 ,  C08G61/126 ,  C08J5/18 ,  C08J7/0427 ,  C08J7/16 ,  C09D5/24 ,  C09D7/63 ,  H01B1/127 ,  B05D2201/02 ,  B05D2203/35 ,  B05D2518/00 ,  C08G2261/3247 ,  C08G2261/43 ,  C08G2261/91 ,  C08G2261/94 ,  C08G2261/95

Abstract: A method for producing a PEDOT film on a substrate comprising a substrate and at least one PEDOT layer on a surface of the substrate is disclosed. The method comprises applying a solution comprising an oxidant and a base inhibitor on a surface of the substrate; subjecting the oxidant-coated substrate to a polymerization step by exposing the surface(s) of the oxidant-coated substrate to EDOT monomer vapour at a polymerization temperature; and wherein, during the polymerization step, the temperature of the oxidant-coated substrate is kept at a controlled substrate temperature and wherein the controlled substrate temperature is 2-40° C. lower than the polymerization temperature. Further is disclosed a conducting PEDOT film, an electronic device comprising the conducting PEDOT film and different uses of the conducting PEDOT film. Further, is disclosed a method for producing a polymer film formed of a copolymer, a conducting polymer film, an electronic device comprising the conducting polymer film and different uses of the conducting polymer film.

公开(公告)号：US20240051976A1

公开(公告)日：2024-02-15

申请号：US18269916

申请日：2021-12-23

Applicant: Turun Yliopisto

Inventor： Anu AIRAKSINEN ,  sofia OTARU ,  Andreas PAULUS ,  Mirrka SARPARANTA

IPC: C07F5/02 ,  C07B59/00

CPC classification number: C07F5/027 ,  C07B59/004 ,  C07B2200/05

Abstract: A tracer compound, or a pharmaceutically acceptable salt or solvate thereof is disclosed, the tracer compound having a structure comprising of a tetrazine moiety, a zwitterion moiety and a linker moiety, the linker moiety linking together the tetrazine moiety and the zwitterion moiety, and the linker moiety being comprised of specific parts S1-Y—S2 disclosed herein. Furthermore, an adduct of the tracer compound and a trans-cyclooctene (TCO)-derivatized targeting moiety, and a method for manufacturing the tracer compound and the adduct are disclosed.

公开(公告)号：US20240008754A1

公开(公告)日：2024-01-11

申请号：US18253569

申请日：2021-11-20

Applicant: Turun yliopisto

Inventor： Tero KOIVISTO ,  Tuukka PANULA ,  Matti KAISTI ,  Mikko PÄNKÄÄLÄ

IPC: A61B5/021 ,  A61B5/318 ,  A61B5/00

CPC classification number: A61B5/02141 ,  A61B5/02125 ,  A61B5/318 ,  A61B5/6822 ,  A61B5/0002

Abstract: An apparatus for measuring a jugular vein pressure waveform includes a rotation sensor configured to produce a measurement signal when being against a skin of an individual and in a movement sensing relation with a jugular vein of the individual. The apparatus includes a processing system configured to receive the measurement signal and produce a waveform of a motion of the skin in a direction perpendicular to the skin based on the measurement signal indicative of rotation of the rotation sensor, where the waveform of the motion of the skin is indicative of the jugular vein pressure waveform. The rotation sensor that measures rotation is more insensitive to movements not related to variation of the jugular vein pressure than for example an acceleration sensor.

公开(公告)号：US20210080458A1

公开(公告)日：2021-03-18

申请号：US17101693

申请日：2020-11-23

Applicant: TURUN YLIOPISTO

Inventor： Robert Moulder ,  Santosh BHOSALE ,  David GOODLETT ,  Harri LÄHDESMÄKI ,  Olli SIMELL ,  Riitta LAHESMAA

IPC: G01N33/564 ,  G01N33/92

Abstract: The present invention relates to methods for predicting a risk of a subject for Type 1 diabetes (T1D) on the basis of expression levels of protein markers in a sample obtained from the subject. The present invention also relates to in vitro kits for use in said methods.

公开(公告)号：US20190136322A1

公开(公告)日：2019-05-09

申请号：US16229699

申请日：2018-12-21

Applicant: Turun yliopisto

Inventor： Henna Kallionpaa ,  Laura L. Elo ,  Essi Laajala ,  Juha Mykkanen ,  Olli Simell ,  Riitta Lahesmaa ,  Harri Lahdesmaki ,  Lingjia Kong ,  Soile Tuomela ,  Niina Lietzen

IPC: C12Q1/6883

Abstract: The present invention relates to methods, transcriptome profiles and kits useful for determining, before seroconversion, the risk that an individual will develop Type 1 diabetes (T1D).

公开(公告)号：US20130197063A1

公开(公告)日：2013-08-01

申请号：US13849210

申请日：2013-03-22

Applicant: Turun Yliopisto

Inventor： Jukka WESTERMARCK ,  Pietri PUUSTINEN ,  Melissa JUNTTILA

IPC: C12N15/113

CPC classification number: C12N15/1136 ,  C07K14/475 ,  C12N15/113 ,  C12N2310/14 ,  G01N33/574 ,  G01N33/57419 ,  G01N2333/4706 ,  G01N2500/02

Abstract: This invention relates to the inhibition of a newly discovered growth-stimulating protein in an individual. Further, the invention relates to a method for preventing or treating a cancer, or preventing or treating cancer growth, invasion or metastasis, or preventing or treating other hyperproliferative diseases in an individual, by down regulating the expression of said growth-stimulating protein or by inactivating said protein. Still further, the invention concerns a method for diagnosing cancer or other hyperproliferative diseases in an individual based on said growth-stimulating protein.

Abstract translation: 本发明涉及对个体中新发现的生长刺激蛋白的抑制。 此外，本发明涉及通过下调所述生长刺激性蛋白质的表达或通过下述方法来预防或治疗癌症，或预防或治疗癌症生长，侵袭或转移，或预防或治疗个体中其它过度增殖性疾病的方法 使所述蛋白失活。 此外，本发明涉及一种基于所述生长刺激性蛋白来诊断个体中的癌症或其它过度增殖性疾病的方法。

公开(公告)号：US20230005786A1

公开(公告)日：2023-01-05

申请号：US17931445

申请日：2022-09-12

Applicant: Turun yliopisto

Inventor： Pekka LAUKKANEN ,  Mikhail Kuzmin ,  Jaakko Mäkelä ,  Marjukka Tuominen ,  Marko Punkkinen ,  Antti Lahti ,  Kalevi Kokko ,  Juha-Pekka Lehtio

IPC: H01L21/762 ,  H01L21/02 ,  H01L23/31

Abstract: A method for forming a semiconductor structure comprising a silicon-on-insulator layer structure with crystalline silicon oxide SiOx as the insulator material comprises: providing a crystalline silicon substrate having a substantially clean deposition surface in a vacuum chamber; heating the silicon substrate to an oxidation temperature To in the range of 550 to 1200 ° C.; supplying, while keeping the silicon substrate in the oxidation temperature, with an oxidation pressure Po in the range of 1·10−8 to 1·10−4 mbar in the vacuum chamber, molecular oxygen O2 into the vacuum chamber with an oxygen dose Do in the range of 0.1 to 1000 Langmuir; whereby a crystalline silicon oxide layer with a thickness of at least two molecular layers is formed within the silicon substrate, between a crystalline silicon base layer and a crystalline silicon top layer. Related semiconductor structures are described.

公开(公告)号：US20220390403A1

公开(公告)日：2022-12-08

申请号：US17776758

申请日：2020-11-16

Applicant: Turun yliopisto

Inventor： Arto PELTOLA ,  Tatu PELTOLA

IPC: G01N27/04

Abstract: A moisture sensor (100) that comprises a contact surface (105) for contacting a polishing pad (503), and a first, a second and a third electrical contact element (101, 102, 103) electrically isolated from each other, the electrical contact elements (101, 102, 103) being disposed within the moisture sensor (100) so that they are exposed at the contact surface (105). Also a polishing device and a method for measuring the moisture in a polishing pad (503) is disclosed using the moisture sensor (100).