公开(公告)号：US20160139129A1

公开(公告)日：2016-05-19

申请号：US14898254

申请日：2014-06-13

申请人： UNIVERSIDAD DE GRANADA ,  SERVICIO ANDALUZ DE SALUD ,  UNIVERSIDAD DE JAÉN

发明人： Carolina Torres Perales ,  Sonia Perales Romero ,  Juan Ramón Delgado Pérez ,  Antonio Irigoyen Medina ,  María José Alejandre Pérez ,  José Iglesias Gómez ,  Rogelio Palomino Morales ,  Octavio Caba Pérez ,  José Carlos Prados Salazar ,  Antonia Aránega Jiménez ,  Ana Linares Gil

IPC分类号： G01N33/574 ,  C07K16/24 ,  C07K16/28 ,  C07K16/22

CPC分类号： G01N33/57438 ,  C07K16/22 ,  C07K16/24 ,  C07K16/243 ,  C07K16/248 ,  C07K16/28 ,  G01N2333/47 ,  G01N2333/50 ,  G01N2333/52 ,  G01N2333/522 ,  G01N2333/5412 ,  G01N2800/60

摘要： The invention related to biomarkers, a method and a kit for early diagnosis of pancreatic cancer, in particular of pancreatic ductal adenocarcinoma (PDAC); and to biomarkers, a method and a kit or device for predicting or prognosticating an individual's response to combination treatment with a nucleoside analogue (preferably gemcitabine) and with a growth factor receptor (preferably erlotinib) in patients with pancreatic ductal adenocarcinoma.

摘要翻译： 本发明涉及生物标志物，胰腺癌早期诊断方法和试剂盒，特别是胰腺导管腺癌（PDAC）; 以及生物标志物，用于预测或预测个体对与胰腺导管腺癌患者的核苷类似物（优选吉西他滨）和生长因子受体（优选厄洛替尼）的联合治疗反应的方法和试剂盒或装置。

公开(公告)号：US20230372575A1

公开(公告)日：2023-11-23

申请号：US18200259

申请日：2023-05-22

申请人： Universidad de Granada ,  Bioiberica, S.A.U. ,  Universidad de Jaén

发明人： Juan Antonio MARCHAL CORRALES ,  Elena LÓPEZ RUIZ ,  Patricia GÁLVEZ MARTÍN ,  Carlos CHOCARRO WRONA

IPC分类号： A61L15/60 ,  A61L15/44 ,  A61L15/32

CPC分类号： A61L15/60 ,  A61L15/44 ,  A61L15/325 ,  A61L2300/64 ,  A61L2300/22 ,  A61L2300/252 ,  A61L2430/34

摘要： The present invention relates to hydrogels that include native skin components, as well as to bio-inks, compositions and dressings based on the same. Furthermore, the invention relates to their uses in regenerative medicine, in particular, in the regeneration, repair and replacement of skin tissue, and a method for obtaining the hydrogels of the invention.

公开(公告)号：US20170226472A1

公开(公告)日：2017-08-10

申请号：US15501718

申请日：2015-08-04

申请人： Universidad de Granada ,  Universidad de Jaén ,  Servicio Andaluz de Salud

发明人： Juan Antonio Marchal Corrales ,  Gema Jiménez González ,  Cynthia Morata Tarifa ,  María Ángel García Chaves ,  Macarena Perán Quesada

IPC分类号： C12N5/00 ,  C12N5/095

CPC分类号： C12N5/0037 ,  C12N5/0695 ,  C12N2500/90 ,  C12N2501/10 ,  C12N2501/11 ,  C12N2501/113 ,  C12N2501/12 ,  C12N2501/165 ,  C12N2501/22 ,  C12N2501/2306 ,  C12N2501/2308 ,  C12N2501/2312 ,  C12N2501/2323 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/91 ,  C12N2501/999 ,  C12N2509/00

摘要： The present invention relates to a serum-free conditioned medium that solves the drawbacks mentioned in the prior art, as it does not require prior handling of the cells, and it furthermore allows starting from a large population with no additional cost. This medium favors in vitro proliferation and conservation of the pluripotency potential that allows maintaining a state that is undifferentiated with respect to the subpopulation of cancer stem cells (CSCs) and in turn does not allow survival of the differentiated cells.