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公开(公告)号：US11179348B2
公开(公告)日：2021-11-23
申请号：US15746311
申请日：2016-06-09
申请人： FUNDACIÓN UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR , UNIVERSITAT DE VALÈNCIA-ESTUDI GENERAL , FUNDACIÓ INVESTIGACIÓ HOSPITAL GENERAL UNIVERSITARI DE VALÈNCIA PER A LA INVESTIGACIÓ BIOMÈDICA I CIÈNCIES DE LA SALUT , IDCQ HOSPITALES Y SANIDAD, S.L.U.
发明人： José María Estrela Arigüel , María Benlloch García , María Elena Plá Obrador , Lilian Soraya Vallés Martín , María Lucía Rodríguez Romero , Joan Antoni Sirerol Talens , Javier Luis Alcácer García , José Alfredo Pellicer Artés , Rosario Salvador Palmer , Guillermo María Sáez Tormo , Concepción Cerdá Micó
IPC分类号： A61K31/09 , A61P35/00 , A61K31/225 , A61K31/277 , A61K31/42 , A61K31/4412 , A61K31/551 , A61K31/635
摘要： The present invention relates to a combination comprising pterostilbeneor pterostilbene phosphate or a pharmaceutically acceptable salt thereof, a glutathione depleting agent and a cancer chemotherapeutic agent. The invention also relates to the medical use of this combination, in particular for the treatment and/or prevention of cancer.
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公开(公告)号：US20210261577A1
公开(公告)日：2021-08-26
申请号：US17057808
申请日：2019-05-23
摘要： The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure.
The invention also relates to methods for obtaining them with high yields, in addition to their uses in the generation of solar fuels, photoactivated degradation, photoreduction of CO2, heterogeneous catalysis, as a component or part of an electronic component and/or as a porous or photoactive coating for controlling pollutants, inter alia.-
公开(公告)号：US20200264190A1
公开(公告)日：2020-08-20
申请号：US16346978
申请日：2017-11-06
申请人： Centro de Investigación Biomédica en Red (CIBER-ISCIII) , Fundación INCLIVA , Universitat de València Estudi General
IPC分类号： G01N33/68
摘要： The present invention proposes a novel method for the detection of circulating histones H3 and H2B in plasma from sepsis or septic shock (SS) patients, based on mass spectrometry-based methods, in particular based on multiple reaction monitoring targeted mass spectrometry (MRM-MS). Such methods allow quantification of histones using an internal standard and show strong specificity and sensitivity values.
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公开(公告)号：US10508266B2
公开(公告)日：2019-12-17
申请号：US15576798
申请日：2016-05-24
申请人： UNIVERSITAT DE VALÈNCIA (ESTUDI GENERAL) , INSTITUTO VALENCIANO DE INVESTIGACIONES AGRARIAS (IVIA)
摘要： A method is for prevention and/or biological control of wilt caused by Ralstonia solanacearum, by use of suitable bacteriophages. In addition a method uses the structural characterisation, genome sequence and activity of three specific lytic bacteriophages of R. solanacearum. Podovirus presents an elevated stability between 4° C. and 30° C. in an aqueous medium in the absence of a host. As a result of the high level of stability, lytic activity, elevated specificity towards R. solanacearum and the absence of activity against the microbiota associated with the plants to be protected, bacteriophages are used for the biological control of R. solanacearum in river courses and irrigation water, as well as in a method for preventing and/or controlling the wilt produced by the bacteria, in which at least one of the bacteriophages, or combinations thereof, are delivered to the plants and/or the soil in the irrigation water.
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公开(公告)号：US20240149259A1
公开(公告)日：2024-05-09
申请号：US18526495
申请日：2023-12-01
CPC分类号： B01J35/39 , B01J21/063 , B01J35/395 , B01J35/45 , B01J37/0215 , B01J37/345
摘要： The present invention relates to a photocatalyst nanomaterial comprising a solid substrate and a metal oxide/oxyhydroxide arranged on the solid substrate forming a coating having a thickness comprised between 1 nm and 1 micrometer and having an amorphous structure. The invention also relates to a nanometric coating which comprises the described photocatalyst material and metallic nanoparticles, as well as to the method for obtaining the catalyst material, to the use of the catalyst material as a photocatalyst in the ultrafast synthesis of metallic nanoparticles, and to the use of the nanometric coating in the manufacture of optical sensors, biocidal coatings and elimination of reactive oxygen species.
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公开(公告)号：US20240131352A1
公开(公告)日：2024-04-25
申请号：US18546214
申请日：2022-02-11
发明人： José María ESTRELA ARIGÜEL , José Juan HERRERA GASPAR , Rosa María CIBRIAN ORTIZ DE ANDA , Enrique NAVARRO CAMBA , María Elena OBRADOR PLA
摘要： An apparatus (1) for treating a cancerous target site is provided. The apparatus comprises an electromagnetic emitter (10) comprising one or more electrodes with an electrically insulating coating for preventing electrical contact between the electrodes and the target site. The electromagnetic emitter (10) is configured to provide a tumour treating field at a target site (30) via the one or more electrodes, the tumour treating field being non-ionizing alternating electromagnetic field having a frequency of between 10 kHz to 300 kHz; and further having a magnetic flux density of between 0.1 pT and 1 mT. The apparatus further comprises a heat source (20) configured to provide heating at the target site to cause hyperthermia at the target site. The apparatus is configured to apply the non-ionizing alternating electromagnetic field and the heating independently. The apparatus comprises an electronic controller for electronically controlling the electromagnetic emitter and the heat source.
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公开(公告)号：US11933676B2
公开(公告)日：2024-03-19
申请号：US17429834
申请日：2020-02-14
CPC分类号： G01J9/00 , G02B21/06 , G02B21/365
摘要： The present invention relates to a microscope for quantitative measurements of the wavefront, comprising:
means for the illumination of a sample (T);
an objective lens (2);
an ordered two-dimensional arrangement of lenses (3), with a spacing pμ greater than 500 μm and a relative aperture of less than 10;
an image sensor (4) located in a capture space (Ec) to receive the light scattered by the sample (T), and to acquire spatial and angular information on the object wavefront associated therewith; and
a computational entity to perform a computational reconstruction of the object wavefront from the spatial and angular information.
Other aspects of the invention relate to a method, a computer program and a product incorporating the same, adapted for the performance of the functions of the computational entity of the microscope, as well as to a module and a kit for a microscope.-
8.发明公开公开(公告)号：US20230346769A1
公开(公告)日：2023-11-02
申请号：US18004932
申请日：2021-07-09
发明人： Enrique Gargía-España Monsonís , María Paz Clares García , Estefanía Delgado Pinar , Clotilde Marín Sánchez , Manuel Sánchez Moreno , Rubén Martín Escolano , Álvaro Martín Montes
IPC分类号： A61K31/4406 , A61K31/4409 , A61P33/02 , A61K31/47 , A61K31/4402 , A61K45/06
CPC分类号： A61K31/47 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K45/06 , A61P33/02
摘要： Use of simple acyclic polyamines for the treatment of parasites of the family Trypanosomatidae
The present invention provides the use of certain single acyclic polyamines of Formula (I), attached to heterocycles, for the treatment of leishmaniasis and trypanosomiasis. All the compounds studied show antiparasitic activity against Leishmania species, comparable or superior to that of the active ingredient of the drug commonly used to treat this disease, but with a macrophage toxicity similar to or, in most cases, lower than that of the commercial reference compound, and with higher selectivity indices against strains representative of the three clinical forms of the disease: cutaneous, mucocutaneous and visceral. The compounds show ability to inhibit parasite superoxide dismutase, generally at concentrations lower than those required to inhibit human superoxide dismutase. All this supports its usefulness for treating leishmaniasis and also trypanosomiasis.-
公开(公告)号：US20220305039A1
公开(公告)日：2022-09-29
申请号：US16614244
申请日：2018-05-16
申请人： UNIVERSITAT DE VALÈNCIA- ESTUDI GENERAL , FUNDACIÓN UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR , Elysium Health, Inc.
IPC分类号： A61K31/706 , A61K31/09 , A61K31/23 , A61P25/28
摘要： Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.
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10.发明授权公开(公告)号：US11365227B2
公开(公告)日：2022-06-21
申请号：US16955370
申请日：2018-12-21
发明人： María Dolores Real García , Carolina Rausell Segarra , Inmaculada García Robles , María Benito Jardón , Aída Robles Fort
摘要： The present invention relates to a peptide derived from the defensin-3 from the red flour beetle Tribolium castaneum, to pharmaceutical compositions containing same, and to the use thereof as an antimicrobial in the treatment of infections caused by gram-positive bacteria, gram-negative bacteria and fungi. The invention also relates to the use of the peptide and pharmaceutical compositions containing same, in the treatment of cancer, particularly breast cancer. The compound described is a peptide derived from defensin-3 from the red flour beetle T. castaneum.
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