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公开(公告)号：US20240076718A1
公开(公告)日：2024-03-07
申请号：US18260017
申请日：2021-12-30
发明人： Francisco MARTÍN MOLINA , Araceli AGUILAR GONZÁLEZ , Noelia MALDONADO PÉREZ , Juan José DÍAZ MOCHÓN
IPC分类号： C12Q1/6816 , C12N9/22 , C12N15/11
CPC分类号： C12Q1/6816 , C12N9/22 , C12N15/11 , C12N2310/20 , C12N2310/3181
摘要： CRISPNA, a new tool for genome editing and diagnosis. The present invention relates to methods and systems for genome editing and diagnosis, and specifically relates to use of Peptide Nucleic Acids (PNAs) to direct the Cas proteins to their DNA or RNA targets.
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2.发明公开公开(公告)号：US20230414561A1
公开(公告)日：2023-12-28
申请号：US18463707
申请日：2023-09-08
申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , UNIVERSITE PARIS CITE , FONDATION IMAGINE , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) , UNIVERSIDAD DE GRANADA
IPC分类号： A61K31/353 , A61P19/00
CPC分类号： A61K31/353 , A61P19/00
摘要： FGFR3-related chondrodysplasias represent a group of rare diseases. Among them, achondroplasia, a nonlethal form of chondrodysplasia, is the most common type of dwarfism. The mutation, which produce an increase of FGFR3 function, affects many tissues, most strikingly the cartilaginous growth plate and bone in the growing skeleton, leading to a variety of manifestations and complications. In attempt to find a new therapeutic approach for FGFR3-related chondrodysplasia, the inventors purified (−)-epicatechin from T. cacao and showed that (−)-epicatechin treatment significantly increases the length of the Fgfr3Y367C/+ femurs comparing to Fgfr3+/+ femurs and improves the whole growth plate cartilage. The present invention thus relates to the use of (−)-epicatechin for the treatment of FGFR3-related chondrodysplasias.
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3.发明公开公开(公告)号：US20230404953A1
公开(公告)日：2023-12-21
申请号：US18254618
申请日：2021-12-10
发明人： Luis Carlos LÓPEZ GARCÍA , Agustín HIDALGO GUTIÉRREZ , Eliana BARRIOCANAL CASADO , Pilar GONZÁLEZ GARCÍA , Mª Elena DÍAZ CASADO
IPC分类号： A61K31/192 , A61P3/04
CPC分类号： A61K31/192 , A61P3/04
摘要： The present invention relates to β-resorcylic acid for use in reducing the amount of white adipose tissue. The inventors have discovered that β-resorcylic acid causes a selective reduction of white adipose tissue without affecting skeletal muscle mass. The present invention thereby allows the therapeutic use of β-resorcylic acid in preventing the accumulation of white adipose tissue or in reducing white adipose tissue. The present invention also relates to a pharmaceutical composition, to the non-therapeutic use of β-resorcylic acid, and to a nutraceutical composition or functional food, dietary product, or nutritional supplement.
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4.发明公开公开(公告)号：US20230276563A1
公开(公告)日：2023-08-31
申请号：US18020293
申请日：2021-08-09
CPC分类号： H05H3/06 , A61N5/1078 , A61N2005/109 , A61N2005/1094
摘要： The invention provides a device for the production, moderation and configuration of a neutron beam, comprising: an inlet opening (1) through which a proton beam is directed; a target (2) against which the proton beam is accelerated in order to generate neutrons; a moderator (3) to bring the neutrons to energies of the epithermal range; a reflective cover (4) surrounding the moderator (3); a filtration stage (5); an outlet opening (6) for the neutron beam, and a shield (7) to suppress the neutrons and gamma-radiation that do not exit the device via said outlet opening. The filtration stage (5) comprises at least three layers to filter respectively: rapid neutrons, thermal neutrons and gamma-radiation The invention is of use in neutron capture therapies, and more specifically, in boron therapies.
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公开(公告)号：US20230270799A1
公开(公告)日：2023-08-31
申请号：US18004082
申请日：2021-07-01
发明人： José Manuel DOMÍNGUEZ VERA , José Manuel DELGADO LÓPEZ , Ana GONZÁLEZ GARNICA , Gloria Belén RAMIREZ RODRIGUEZ , Natividad GÁLVEZ RODRÍGUEZ , Laura SABIO RODRÍGUEZ
IPC分类号： A61K35/747 , A61P31/04 , A61K35/745 , A01N63/20 , A01N43/16 , A61K31/717 , C12N1/20 , A23P20/10 , A23L33/135 , C12N11/04
CPC分类号： A61K35/747 , A61P31/04 , A61K35/745 , A01N63/20 , A01N43/16 , A61K31/717 , C12N1/20 , A23P20/105 , A23L33/135 , C12N11/04 , A23Y2220/35 , A23Y2220/37
摘要： The invention relates to biomaterials, which comprise a bacterial cellulose matrix and probiotics entrapped in said bacterial cellulose. The invention also relates to methods for obtaining the biomaterial, as well as uses of the biomaterial in medicine. It also relates to coated food products wherein the coat is composed of said biomaterial wherein the coat acts to prevent the proliferation of undesired bacteria. It also relates to packaged medical devices, wherein the package comprises said biomaterial also preventing growth of pathogenic bacteria.
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公开(公告)号：US11234964B2
公开(公告)日：2022-02-01
申请号：US16498825
申请日：2018-04-02
发明人： Germaine Escames Rosa , Darío Acuña Castroviejo , Ana Guerra-Librero Rite , Beatriz Irene Fernández Gil , Javier Florido Ruiz
IPC分类号： A61K31/4045 , A61P35/00 , A61K9/00 , A61K45/06
摘要： The present invention relates to the use of melatonin for the preparation of a pharmaceutical composition suitable for intratumoral administration for the treatment of tumors. This composition comprises high concentrations of melatonin, melatonin derivatives or metabolites, such that melatonin exerts an oxidizing effect, increasing the production of free radicals and activating cell death.
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公开(公告)号：US10856551B2
公开(公告)日：2020-12-08
申请号：US15500440
申请日：2015-07-31
发明人： María Victoria Béjar Luque , Inmaculada Llamas Company , Cristina Ruíz García , Emilia Quesada Arroquia
摘要： The invention relates to the use of microorganisms as plant growth stimulants and for the biological control of bacteria, insects, fungi and phytopathogenic nematodes. More specifically, the invention relates to the use of microorganisms of the genus Bacillus, more specifically the Bacillus methylotrophicus species, as well as to cultures thereof, compositions comprising these bacteria, different culture methods and the products comprising same, as plant growth stimulants and for the biological control of bacteria, insects, fungi and phytopathogenic nematodes.
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8.发明公开公开(公告)号：US20240002413A1
公开(公告)日：2024-01-04
申请号：US18469333
申请日：2023-09-18
CPC分类号： C07F7/28 , C07F1/08 , C07B2200/13
摘要： The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure. The invention also relates to methods for obtaining them with high yields, in addition to their uses in the generation of solar fuels, photoactivated degradation, photoreduction of CO2, heterogeneous catalysis, as a component or part of an electronic component and/or as a porous or photoactive coating for controlling pollutants, inter alia.
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公开(公告)号：US20230414692A1
公开(公告)日：2023-12-28
申请号：US18248915
申请日：2021-10-11
发明人： Francisco BERMÚDEZ PÉREZ , Jose Carlos PRADOS SALAZAR , Consolación MELGUIZO ALONSO , Jesús Mª PORRES FOULQUIE , Cristina MESAS HERNÁNDEZ , Rosario MARTÍNEZ MARTÍNEZ , Milagros GALISTEO MOYA , Raúl ORTIZ QUESADA , Laura CABEZA MONTILLA , María LÓPEZ-JURADO ROMERO DE LA CRUZ
IPC分类号： A61K36/81 , A61K45/06 , A61K31/343 , A61K31/7028 , A61K31/7048 , A61K31/7032 , A61P35/00
CPC分类号： A61K36/81 , A61K45/06 , A61K31/343 , A61K31/7028 , A61K31/7048 , A61K31/7032 , A61P35/00 , A61K2236/15 , A61K2236/333 , A61K2236/53 , A61K2236/39
摘要： The present invention provides a method for obtaining an ethanolic extract from mature seeds of Solanum melongena, preferably defatted, characterized in that they are extracted with a hydroalcoholic solution containing 50% ethanol, at acid PH, preferably under a nitrogen atmosphere and for short periods of time, no longer than 1-2 h. The extracts obtained from different varieties of Solanum melongena have a high polyphenol content and show potent antitumor activity against colon adenocarcinoma, pancreatic adenocarcinoma and glioblastoma multiforme cell lines, even against chemotherapy-resistant lines, but with low toxicity to human hepatocytes. Therefore, the extracts of the invention are proposed for use in the treatment of colon adenocarcinoma, pancreatic adenocarcinoma and glioblastoma multiforme, including those resistant to currently used chemotherapies.
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公开(公告)号：US11787824B2
公开(公告)日：2023-10-17
申请号：US17057808
申请日：2019-05-23
CPC分类号： C07F7/28 , C07F1/08 , C07B2200/13
摘要： The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure.
The invention also relates to methods for obtaining them with high yields, in addition to their uses in the generation of solar fuels, photoactivated degradation, photoreduction of CO2, heterogeneous catalysis, as a component or part of an electronic component and/or as a porous or photoactive coating for controlling pollutants, inter alia.
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