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    RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS
    1.
    发明申请
    RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS 有权
    用作抗病毒剂的罗丹明组合物

    公开(公告)号：US20090137644A1

    公开(公告)日：2009-05-28

    申请号：US10975761

    申请日：2004-10-28

    Applicant: Rajinder Singh ,  Usha Ramesh ,  Sarkiz D. Issakani ,  Gary Charles Look

    Inventor： Rajinder Singh ,  Usha Ramesh ,  Sarkiz D. Issakani ,  Gary Charles Look

    IPC: A61K31/427 ,  C12N5/02 ,  C07D417/06

    CPC classification number: A61K31/421 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4166 ,  A61K31/426

    Abstract: This invention describes compounds and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In particular, the compounds and compositions are useful for treating diseases caused by viruses such as poxviruses and retroviruses. The invention further provides for methods of treating smallpox, Herpes virus and HIV infection in patients using the compounds and compositions of the invention.

    Abstract translation: 本发明描述了可用作泛素化抑制剂的化合物和药物组合物。 本发明的化合物和组合物可用作涉及泛素化的生物体的生物化学途径的抑制剂。 特别地，化合物和组合物可用于治疗由诸如痘病毒和逆转录病毒的病毒引起的疾病。 本发明还提供了使用本发明的化合物和组合物治疗患者天花，疱疹病毒和HIV感染的方法。

    Ubiquitin ligase inhibitors
    3.
    发明申请
    Ubiquitin ligase inhibitors 审中-公开
    泛素连接酶抑制剂

    公开(公告)号：US20060160869A1

    公开(公告)日：2006-07-20

    申请号：US11325845

    申请日：2006-01-05

    Applicant: Rajinder Singh ,  Usha Ramesh ,  Sarkiz Issakani ,  Jianing Huang ,  Taisei Kinoshita ,  Tarikere Gururaja

    Inventor： Rajinder Singh ,  Usha Ramesh ,  Sarkiz Issakani ,  Jianing Huang ,  Taisei Kinoshita ,  Tarikere Gururaja

    IPC: A61K31/427 ,  A61K31/426 ,  C07D277/38 ,  C07D417/02

    CPC classification number: C07D277/38 ,  C07D277/42

    Abstract: This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors, particularly ubiquitin ligase inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved, such as signal transduction pathways. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound or pharmaceutical composition according to the invention. Particularly, the compounds and pharmaceutical compositions are useful to inhibit the ubiquitin ligase activity of MDM2.

    Abstract translation: 本发明描述了可用作泛素抑制剂，特别是泛素连接酶抑制剂的化合物和药物组合物。 本发明的化合物和药物组合物可用作其中涉及泛素化的生物体的生物化学途径的抑制剂，例如信号转导途径。 本发明还包括使用本发明的化合物和药物组合物来治疗需要抑制泛素化的病症。 此外，本发明包括在细胞中抑制泛素化的方法，包括使需要泛素化抑制的细胞与根据本发明的化合物或药物组合物接触。 特别地，化合物和药物组合物可用于抑制MDM2的泛素连接酶活性。

    Ubiquitin ligase inhibitors
    7.
    发明申请
    Ubiquitin ligase inhibitors 审中-公开
    泛素连接酶抑制剂

    公开(公告)号：US20050282818A1

    公开(公告)日：2005-12-22

    申请号：US11158957

    申请日：2005-06-22

    Applicant: Usha Ramesh ,  Gary Look ,  Jianing Huang ,  Rajinder Singh ,  Richard Mattis

    Inventor： Usha Ramesh ,  Gary Look ,  Jianing Huang ,  Rajinder Singh ,  Richard Mattis

    IPC: C07D271/12 ,  C07D285/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D491/10 ,  A61K31/496 ,  A61K31/4245 ,  C07D413/02

    CPC classification number: C07D271/12 ,  C07D285/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D491/10

    Abstract: This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors, particularly ubiquitin ligase inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved, such as signal transduction pathways. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound or pharmaceutical composition according to the invention. Particularly, the compounds and pharmaceutical compositions are useful to inhibit the ubiquitin ligase activity of TRAF6.

    Abstract translation: 本发明描述了可用作泛素抑制剂，特别是泛素连接酶抑制剂的化合物和药物组合物。 本发明的化合物和药物组合物可用作其中涉及泛素化的生物体的生物化学途径的抑制剂，例如信号转导途径。 本发明还包括使用本发明的化合物和药物组合物来治疗需要抑制泛素化的病症。 此外，本发明包括抑制细胞泛素化的方法，包括使其中需要泛素化抑制的细胞与根据本发明的化合物或药物组合物接触。 特别地，化合物和药物组合物可用于抑制TRAF6的泛素连接酶活性。

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