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公开(公告)号：US20150033417A9
公开(公告)日：2015-01-29
申请号：US11004678
申请日：2004-12-03
Applicant: Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
Inventor： Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
CPC classification number: C12N15/8216 , C07K14/415
Abstract: The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described herein.
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2.发明授权公开(公告)号：US09029523B2
公开(公告)日：2015-05-12
申请号：US11004678
申请日：2004-12-03
Applicant: Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
Inventor： Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
CPC classification number: C12N15/8216 , C07K14/415
Abstract: The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described herein.
Abstract translation: 本发明提供构成植物基因组片段的DNA分子，以及由此编码的多肽。 DNA分子可用于指定细胞中的基因产物，作为启动子或蛋白质编码序列或作为UTR或作为3'终止序列，并且还可用于控制染色体中基因的行为， 在控制基因的表达或用于遗传作图，识别或分离相同或相关的DNA片段，或特定个体生物体的鉴定或用于具有共同性状的一组生物体的聚类的工具。 具有该数据的本领域普通技术人员可以通过本领域已知的或本文描述的重组方法获得克隆的DNA片段，合成的DNA片段或构成所需序列的多肽。
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公开(公告)号：US06426186B1
公开(公告)日：2002-07-30
申请号：US09484970
申请日：2000-01-18
Applicant: Karen A. Jones , Wayne Volkmuth , Michael G. Walker
Inventor： Karen A. Jones , Wayne Volkmuth , Michael G. Walker
IPC: C12Q168
CPC classification number: C12Q1/6883 , C12Q2600/158 , C40B40/00
Abstract: The invention provides polynucleotides and polypeptides that are co-expressed with genes known to be involved in bone remodeling and osteoporosis. The invention also provides expression vectors, host cells, and methods for making a polypeptide, for screening or purifying ligands, and for diagnosing disorders associated with bone remodeling or osteoporosis.
Abstract translation: 本发明提供了与已知参与骨重塑和骨质疏松症的基因共表达的多核苷酸和多肽。 本发明还提供表达载体，宿主细胞和用于制备多肽，筛选或纯化配体以及用于诊断与骨重塑或骨质疏松症相关的疾病的方法。
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公开(公告)号：US20150080266A1
公开(公告)日：2015-03-19
申请号：US14342048
申请日：2012-09-04
Applicant: Wayne Volkmuth , Yann Chong Tan
Inventor： Wayne Volkmuth , Yann Chong Tan
CPC classification number: C12N15/1089 , C12N15/1065 , C12Q1/6869 , C12Q1/6876 , C12Q2600/166 , G06F19/18 , G06F19/22 , C12Q2525/15 , C12Q2535/122 , C12Q2537/165
Abstract: The present disclosure provides methods for optimizing barcode design for multiplex DNA sequencing. Also disclosed are DNA barcodes optimized for use with particular sequencing technologies.
Abstract translation: 本公开提供了用于优化用于多重DNA测序的条形码设计的方法。 还公开了优化用于特定测序技术的DNA条形码。
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5.发明申请公开(公告)号：US20110191912A1
公开(公告)日：2011-08-04
申请号：US11004678
申请日：2004-12-03
Applicant: Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
Inventor： Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
CPC classification number: C12N15/8216 , C07K14/415
Abstract: The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described herein.
Abstract translation: 本发明提供构成植物基因组片段的DNA分子，以及由此编码的多肽。 DNA分子可用于指定细胞中的基因产物，作为启动子或蛋白质编码序列或作为UTR或作为3'终止序列，并且还可用于控制染色体中基因的行为， 在控制基因的表达或用于遗传作图，识别或分离相同或相关的DNA片段，或特定个体生物体的鉴定或用于具有共同性状的一组生物体的聚类的工具。 具有该数据的本领域普通技术人员可以通过本领域已知的或本文描述的重组方法获得克隆的DNA片段，合成的DNA片段或构成所需序列的多肽。
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Patent Agency Ranking
公开(公告)号：US06911345B2
公开(公告)日：2005-06-28
申请号：US09908830
申请日：2001-07-18
Applicant: Stephen Quake , Wayne Volkmuth , Marc Unger
Inventor： Stephen Quake , Wayne Volkmuth , Marc Unger
CPC classification number: C12Q1/68 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/10 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0655 , C12Q1/6869 , C12Q1/6874 , F04B43/043 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , G01N33/549 , C12Q2535/125 , C12Q2565/629 , C12Q2533/101
Abstract: The present invention provides an apparatus for analyzing the sequences of polynucleotides. The apparatus comprises (a) flow cell which has at least one microfabricated multilayer elastomeric synthesis channel; and (b) an inlet port and an outlet port. The inlet port and outlet ports are in fluid communication with the flow cell for flowing fluids into and through the flow cell.
Abstract translation: 本发明提供了一种用于分析多核苷酸序列的装置。 该装置包括（a）具有至少一个微制造的多层弹性体合成通道的流动池; 和（b）入口和出口。 入口端口和出口端口与流动池流体连通，用于将流体流入和流过流动池。
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公开(公告)号：US06566066B1
公开(公告)日：2003-05-20
申请号：US09610906
申请日：2000-07-06
Applicant: Michael G. Walker , Wayne Volkmuth , Tod M. Klinger
Inventor： Michael G. Walker , Wayne Volkmuth , Tod M. Klinger
IPC: C12Q168
Abstract: The invention provides a mammalian cDNA which encodes a mammalian AQP8V. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of pancreatic disorders, particularly type I diabetes. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Abstract translation: 本发明提供编码哺乳动物AQP8V的哺乳动物cDNA。 它还提供使用cDNA，其片段，补体和变体，以及编码的蛋白质，其部分及其抗体用于诊断和治疗胰腺疾病，特别是I型糖尿病。 本发明另外提供用于产生蛋白质的表达载体和宿主细胞和转基因模型系统。
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8.发明授权公开(公告)号：US08877916B2
公开(公告)日：2014-11-04
申请号：US10886468
申请日：2004-07-06
Applicant: Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
Inventor： Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
IPC: C07H21/04 , C12N15/00 , C12N5/10 , C12N15/82 , C07K14/415
CPC classification number: C07K14/415 , C12N15/8216
Abstract: The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described herein.
Abstract translation: 本发明提供构成植物基因组片段的DNA分子，以及由此编码的多肽。 DNA分子可用于指定细胞中的基因产物，作为启动子或蛋白质编码序列或作为UTR或作为3'终止序列，并且还可用于控制染色体中基因的行为， 在控制基因的表达或用于遗传作图，识别或分离相同或相关的DNA片段，或特定个体生物体的鉴定或用于具有共同性状的一组生物体的聚类的工具。 具有该数据的本领域普通技术人员可以通过本领域已知的或本文描述的重组方法获得克隆的DNA片段，合成的DNA片段或构成所需序列的多肽。
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9.发明申请公开(公告)号：US20120084885A1
公开(公告)日：2012-04-05
申请号：US10886468
申请日：2004-07-06
Applicant: Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
Inventor： Nickolai Alexandrov , Nestor Apuya , Vyacheslav Brover , Jean-Baptiste Dumas , Yiwen Fang , Ken Feldmann , Diane Jofuku , Edward A. Kiegle , Bill Kimmerly , Shing Kwok , Peter Mascia , Jack Okamuro , Roger Pennell , Richard Schneeberger , Tatiana Tatarinova , Wayne Volkmuth
CPC classification number: C07K14/415 , C12N15/8216
Abstract: The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described herein
Abstract translation: 本发明提供构成植物基因组片段的DNA分子，以及由此编码的多肽。 DNA分子可用于指定细胞中的基因产物，作为启动子或蛋白质编码序列或作为UTR或作为3'终止序列，并且还可用于控制染色体中基因的行为， 在控制基因的表达或用于遗传作图，识别或分离相同或相关的DNA片段，或特定个体生物体的鉴定或用于具有共同性状的一组生物体的聚类的工具。 具有该数据的本领域普通技术人员可以通过本领域已知的或本文所述的重组方法获得克隆的DNA片段，合成的DNA片段或构成所需序列的多肽
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公开(公告)号：US20050147992A1
公开(公告)日：2005-07-07
申请号：US10967778
申请日：2004-10-18
Applicant: Stephen Quake , Wayne Volkmuth , Marc Unger
Inventor： Stephen Quake , Wayne Volkmuth , Marc Unger
CPC classification number: C12Q1/68 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/10 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0655 , C12Q1/6869 , C12Q1/6874 , F04B43/043 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , G01N33/549 , C12Q2535/125 , C12Q2565/629 , C12Q2533/101
Abstract: Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.
Abstract translation: 在本发明中提供了用于多核苷酸序列的高速，高通量分析的方法以及用于实施所述方法的装置。
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