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    Human complement C3 derivates with cobra venom factor-like function
    1.
    发明申请
    Human complement C3 derivates with cobra venom factor-like function 审中-公开
    人类补体C3衍生物与眼镜蛇毒因子样功能

    公开(公告)号：US20080234191A1

    公开(公告)日：2008-09-25

    申请号：US11890900

    申请日：2007-08-07

    申请人： Carl-Wilhelm Vogel ,  David C. Fritzinger

    发明人： Carl-Wilhelm Vogel ,  David C. Fritzinger

    IPC分类号： A61K38/00 ,  C07K16/00 ,  C12Q1/00 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C07K14/472 ,  A61K38/00 ,  C07K14/463 ,  C07K2319/00

    摘要： A modified human complement C3 protein (C3) is disclosed comprising a substitution of a portion of a human C3 protein, with a corresponding portion of a Cobra Venom Factor protein (CVF) which results in a human C3 protein with CVF functions, but with substantially reduced immunogenicity. Advantageously, the C3 protein can be manipulated to contain at least one of the following CVF functions: increased stability of the C3 convertase and increased resistance to the actions of factors H and/or I. A large number of hybrid C3 proteins containing substitutions in the C-terminal portion of the alpha chain of C3 are presented and tested for the above functions. Methods of treatment of diseases such as reperfusion injury, autoimmune diseases, and other diseases of increased complement activation are presented as well as methods of increasing the effectiveness of gene therapeutics and other therapeutics.

    摘要翻译： 公开了修饰的人补体C3蛋白（C3），其包含部分人C3蛋白的取代与眼镜蛇毒因子蛋白（CVF）的相应部分，其导致具有CVF功能的人C3蛋白，但基本上 免疫原性降低。 有利地，可以操作C3蛋白以包含以下CVF功能中的至少一种：增加C3转化酶的稳定性和增加对因子H和/或I的作用的抗性。大量含有取代的杂合C3蛋白 呈现C3的α链的C末端部分并进行上述功能的测试。 提出了治疗诸如再灌注损伤，自身免疫疾病和其他增加补体活化的疾病的方法以及增加基因治疗剂和其它治疗剂的有效性的方法。

    Method and apparatus for fuel injection in internal combustion engines in particular diesel engines
    3.
    发明授权
    Method and apparatus for fuel injection in internal combustion engines in particular diesel engines 失效
    内燃机特别是柴油发动机燃油喷射的方法和装置

    公开(公告)号：US4378775A

    公开(公告)日：1983-04-05

    申请号：US277426

    申请日：1981-06-25

    申请人： Max Straubel ,  Hermann Eisele ,  Klaus-Dieter Zimmermann ,  Wilhelm Vogel

    发明人： Max Straubel ,  Hermann Eisele ,  Klaus-Dieter Zimmermann ,  Wilhelm Vogel

    IPC分类号： F02B3/06 ,  F02M57/02 ,  F02M59/26 ,  F02M59/36 ,  F02M39/00

    CPC分类号： F02M57/02 ,  F02M59/26 ,  F02M59/366 ,  F02B3/06

    摘要： In the method according to the invention, the inlet pressure and the inlet cross section of the fuel pre-stored in the pump work chamber is constant, and it is solely the opening duration of an inlet valve which is electrically regulated. In addition, a shift in the instant of supply onset controlled in accordance with operating characteristics is attained by means of a variation in the return-flow fuel quantity. A shift in the instant of supply onset, which is undesired when there is a change in the quantity of fuel to be injected, is prevented by means of a simultaneously-effected correction of the return-flow fuel quantity. A fuel injection apparatus suitable for performing the method has, as the inlet valve, a magnetic valve which determines the quantity of fuel pre-stored in the pump work chamber. The rotary position of the pump piston is variable in order to shift or correct the instant of supply onset by means of an adjacent device actuated by an electromechanical adjustment element. An electric control device emitting the metering pulse and a control pulse is connected with a set-point transducer and an adjustment-path transducer of the adjustment device. The apparatus can be equipped with either a pump/nozzle or a normal piston injection pump supplying the injection nozzle via a pressure line, or with a distributor injection pump.

    摘要翻译： 在根据本发明的方法中，预先存储在泵工作室中的燃料的入口压力和入口横截面是恒定的，并且仅仅是电气调节的入口阀的打开持续时间。 此外，通过返回流量燃料量的变化来实现根据操作特性控制的供给开始时刻的变化。 通过同时进行的返回流量燃料量的校正来防止在待喷射燃料量发生变化时不期望的供应开始瞬间的变化。 适于执行该方法的燃料喷射装置具有作为入口阀的确定预先存储在泵工作室中的燃料量的电磁阀。 泵活塞的旋转位置是可变的，以便通过由机电调节元件致动的相邻装置移动或校正供给开始的时刻。 发射计量脉冲和控制脉冲的电气控制装置与调节装置的设定点换能器和调节路径换能器连接。 该装置可以配备有通过压力管线或分配器注射泵供应喷嘴的泵/喷嘴或普通活塞注射泵。

    Human complement C3 derivates with cobra venom factor-like function
    4.
    发明授权
    Human complement C3 derivates with cobra venom factor-like function 有权
    人类补体C3衍生物与眼镜蛇毒因子样功能

    公开(公告)号：US08632780B2

    公开(公告)日：2014-01-21

    申请号：US11579235

    申请日：2005-04-29

    申请人： Carl-Wilhelm Vogel ,  David C. Fritzinger

    发明人： Carl-Wilhelm Vogel ,  David C. Fritzinger

    IPC分类号： A01K39/00 ,  A61K35/14 ,  A61K38/16 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

    CPC分类号： C07K14/472 ,  A61K38/00 ,  C07K14/463 ,  C07K2319/00

    摘要： A modified human complement C3 protein (C3) is disclosed comprising a substitution of a portion of a human C3 protein, with a corresponding portion of a Cobra Venom Factor protein (CVF) which results in a human C3 protein with CVF functions, but with substantially reduced immunogenicity. Advantageously, the C3 protein can be manipulated to contain at least one of the following CVF functions: increased stability of the C3 convertase and increased resistance to the actions of factors H and/or I. A large number of hybrid C3 proteins containing substitutions in the C-terminal portion of the alpha chain of C3 are presented and tested for the above functions. Methods of treatment of diseases such as reperfusion injury, autoimmune diseases, and other diseases of increased complement activation are presented as well as methods of increasing the effectiveness of gene therapeutics and other therapeutics.

    摘要翻译： 公开了修饰的人补体C3蛋白（C3），其包含部分人C3蛋白的取代与眼镜蛇毒因子蛋白（CVF）的相应部分，其导致具有CVF功能的人C3蛋白，但基本上 免疫原性降低。 有利地，可以操作C3蛋白以包含以下CVF功能中的至少一种：增加C3转化酶的稳定性和增加对因子H和/或I的作用的抗性。大量含有取代的杂合C3蛋白 呈现C3的α链的C末端部分并进行上述功能的测试。 提出了治疗诸如再灌注损伤，自身免疫疾病和其他增加补体活化的疾病的方法以及增加基因治疗剂和其它治疗剂的有效性的方法。

    Fuel injection nozzle for internal combustion engines
    7.
    发明授权
    Fuel injection nozzle for internal combustion engines 失效
    内燃机燃油喷嘴

    公开(公告)号：US4516729A

    公开(公告)日：1985-05-14

    申请号：US421195

    申请日：1982-09-22

    申请人： Paul Fussner ,  Karl Hofmann ,  Iwan Komaroff ,  Katsuoki Itoh ,  Kurt Seifert ,  Dietrich Trachte ,  Wilhelm Vogel ,  Hans-Jorg Vogtmann

    发明人： Paul Fussner ,  Karl Hofmann ,  Iwan Komaroff ,  Katsuoki Itoh ,  Kurt Seifert ,  Dietrich Trachte ,  Wilhelm Vogel ,  Hans-Jorg Vogtmann

    IPC分类号： F02M45/08 ,  F02M45/12 ,  F02M61/08 ,  F02M61/10 ,  F02M61/16 ,  B05B1/32

    CPC分类号： F02M45/12 ,  F02M45/08 ,  F02M61/08

    摘要： A fuel injection nozzle for internal combustion engines having a valve needle which enters an intermediate position in a retarded fashion and subsequently reaches its final position quickly. The valve needle is coupled in a positively-engaged manner with a supplementary body which as a result of its mass and/or hydraulically damps the movement of the valve needle over the course of a first stroke portion. At the end of this stroke portion, the supplementary body strikes a shoulder attached to the housing, whereupon the valve needle after the attainment of a notably higher fuel pressure, is separated from the supplementary body and translated quickly into its open position. In special cases, it is also possible for two supplementary bodies to be provided, which are uncoupled one after another from the valve needle and then again recoupled to the valve upon the closure of the valve. With an apparatus of this kind, the injection procedure can be adapted more freely than in the case of the known injection nozzles to a desired course.

    摘要翻译： 一种用于内燃机的燃料喷射喷嘴，其具有以更迟的方式进入中间位置并随后快速到达其最终位置的阀针。 阀针以正向接合的方式与辅助体联接，辅助体由于其质量和/或液压地阻止阀针在第一冲程部分的运动过程中的运动。 在该行程部分的末端，补充体撞击附接到壳体的肩部，由此获得显着较高的燃料压力之后的阀针与补充体分离并迅速转换到其打开位置。 在特殊情况下，也可以提供两个辅助体，这两个辅助体从阀针一个接一个地分离，然后在阀闭合时再次重新连接到阀上。 使用这种装置，与已知的喷嘴的情况相比，注射程序可以更自由地适应于期望的过程。

    Human Complement C3 Derivates with Cobra Venom Factor-Like Function
    9.
    发明申请
    Human Complement C3 Derivates with Cobra Venom Factor-Like Function 有权
    人类补体C3衍生物与眼镜蛇毒素因子样功能

    公开(公告)号：US20080311132A1

    公开(公告)日：2008-12-18

    申请号：US11579235

    申请日：2005-04-29

    申请人： Carl-Wilhelm Vogel ,  David C. Fritzinger

    发明人： Carl-Wilhelm Vogel ,  David C. Fritzinger

    IPC分类号： A61K39/44 ,  C07K19/00 ,  C07K14/435 ,  A61P25/28 ,  C12Q1/00 ,  C12N5/06 ,  C07H21/04 ,  A61P25/16 ,  A61K38/17

    CPC分类号： C07K14/472 ,  A61K38/00 ,  C07K14/463 ,  C07K2319/00

    摘要： A modified human complement C3 protein (C3) is disclosed comprising a substitution of a portion of a human C3 protein, with a corresponding portion of a Cobra Venom Factor protein (CVF) which results in a human C3 protein with CVF functions, but with substantially reduced immunogenicity. Advantageously, the C3 protein can be manipulated to contain at least one of the following CVF functions: increased stability of the C3 convertase and increased resistance to the actions of factors H and/or I. A large number of hybrid C3 proteins containing substitutions in the C-terminal portion of the alpha chain of C3 are presented and tested for the above functions. Methods of treatment of diseases such as reperfusion injury, autoimmune diseases, and other diseases of increased complement activation are presented as well as methods of increasing the effectiveness of gene therapeutics and other therapeutics.

    摘要翻译： 公开了修饰的人补体C3蛋白（C3），其包含部分人C3蛋白的取代与眼镜蛇毒因子蛋白（CVF）的相应部分，其导致具有CVF功能的人C3蛋白，但基本上 免疫原性降低。 有利地，可以操作C3蛋白以包含以下CVF功能中的至少一种：增加C3转化酶的稳定性和增加对因子H和/或I的作用的抗性。大量含有取代的杂合C3蛋白 呈现C3的α链的C末端部分并进行上述功能的测试。 提出了治疗诸如再灌注损伤，自身免疫疾病和其他增加补体活化的疾病的方法以及增加基因治疗剂和其它治疗剂的有效性的方法。