公开(公告)号：US20060170176A1

公开(公告)日：2006-08-03

申请号：US11046310

申请日：2005-01-28

申请人： Thomas Wubben ,  Marvin Maiwald ,  Brandon Carlson ,  Jack Anderson ,  William Brett

发明人： Thomas Wubben ,  Marvin Maiwald ,  Brandon Carlson ,  Jack Anderson ,  William Brett

IPC分类号： B62D7/16 ,  B60G3/01 ,  B60G9/04

CPC分类号： B60B35/001 ,  B60B35/008 ,  B60B35/1054 ,  B60B35/109 ,  B60G3/01 ,  B60G11/27 ,  B60G2200/44 ,  B60G2202/413 ,  B60G2204/126 ,  B60G2204/15 ,  B60G2204/4232 ,  B60G2204/4502 ,  B60G2300/083 ,  B60G2300/40 ,  B60Y2200/22 ,  B62D7/06 ,  B62D49/0678

摘要： An independent strut suspension utilizes upright twin spindles and a spindle cap linked to the spindles that translates vertically along the spindles as the suspension moves over uneven terrain. An upright strut shaft is mounted in a strut journal for axial and rotational movement with respect to the journal. A steering arm is connected for rotation about the strut shaft axis, and the strut shaft moves axially with respect to the steering arm as the frame moves over the uneven terrain. The upright spindles connect the steering arm and the upper mount, and a spring is supported between the upper end of the strut shaft and the upper mount and provides cushioning for the wheel support as the strut shaft moves axially in the journal.

摘要翻译： 独立的支柱悬挂采用直立双主轴和连接到主轴的主轴帽，当悬架在不平坦的地形上移动时，主轴沿着主轴垂直平移。 直立支柱轴安装在支柱轴颈中，用于相对于轴颈轴向和旋转运动。 连接转向臂以围绕支柱轴线旋转，并且当框架在不平坦的地形上移动时，支柱轴相对于转向臂轴向移动。 直立的主轴连接转向臂和上部支架，弹簧支撑在支柱轴的上端和上部支架之间，当支柱轴在轴颈上移动时，它为车轮支撑提供缓冲。

公开(公告)号：US09763777B2

公开(公告)日：2017-09-19

申请号：US14131710

申请日：2012-07-11

申请人： Marcus Atlas ,  William Brett Robertson ,  Robert Jeffrey Marano ,  Sharon Leanne Redmond ,  Peter Luke Santa Maria ,  Brett Levin ,  Bing Mei Teh

发明人： Marcus Atlas ,  William Brett Robertson ,  Robert Jeffrey Marano ,  Sharon Leanne Redmond ,  Peter Luke Santa Maria ,  Brett Levin ,  Bing Mei Teh

IPC分类号： A61F2/18 ,  A61L27/22 ,  A61L27/24 ,  A61L27/38 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61B17/00

CPC分类号： A61F2/18 ,  A61B2017/00787 ,  A61F2002/183 ,  A61L27/227 ,  A61L27/24 ,  A61L27/38 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2430/14

摘要： A device for use in the repair of an ear drum in a subject in need of such treatment, said device: having a tensile strength Youngs Modulus between approximately 12.5 and 40 MPa; comprising one or more membrane layers, wherein at least one membrane layer comprises a plurality of pores; and wherein the device can support proliferation, migration and/or adhesion of cells selected from the group comprising at least any one or more of: keratinocytes, fibroblasts, vascular cells, mucosal epithelial cells, and stem cells.

公开(公告)号：US20140303727A1

公开(公告)日：2014-10-09

申请号：US14131710

申请日：2012-07-11

申请人： Marcus Atlas ,  William Brett Robertson ,  Robert Jeffrey Marano ,  Sharon Leanne Redmond ,  Peter Luke Santa Maria ,  Brett Levin ,  Bing Mei Teh

发明人： Marcus Atlas ,  William Brett Robertson ,  Robert Jeffrey Marano ,  Sharon Leanne Redmond ,  Peter Luke Santa Maria ,  Brett Levin ,  Bing Mei Teh

IPC分类号： A61F2/18

CPC分类号： A61F2/18 ,  A61B2017/00787 ,  A61F2002/183 ,  A61L27/227 ,  A61L27/24 ,  A61L27/38 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2430/14

摘要： A device for use in the repair of an ear drum in a subject in need of such treatment, said device: having a tensile strength Youngs Modulus between approximately 12.5 and 40 MPa; comprising one or more membrane layers, wherein at least one membrane layer comprises a plurality of pores; and wherein the device can support proliferation, migration and/or adhesion of cells selected from the group comprising at least any one or more of: keratinocytes, fibroblasts, vascular cells, mucosal epithelial cells, and stem cells.

摘要翻译： 一种用于在需要这种处理的受试者中修复耳鼓的装置，所述装置具有约12.5至40MPa之间的拉伸强度杨氏模量; 包括一个或多个膜层，其中至少一个膜层包含多个孔; 并且其中所述装置可以支持选自包括角化细胞，成纤维细胞，血管细胞，粘膜上皮细胞和干细胞中的至少任何一个或多个的组的细胞的增殖，迁移和/或粘附。

公开(公告)号：US20110002989A1

公开(公告)日：2011-01-06

申请号：US12920400

申请日：2009-03-04

申请人： William John Curatolo ,  Scott Max Herbig ,  Avinash Govind Thombre ,  Jaymin Chandrakant Shah ,  Sheri L. Shamblin ,  Timothy Lukas ,  William Brett Caldwell ,  Dwayne Thomas Friesen ,  David Keith Lyon ,  Christopher Donovan Craig

发明人： William John Curatolo ,  Scott Max Herbig ,  Avinash Govind Thombre ,  Jaymin Chandrakant Shah ,  Sheri L. Shamblin ,  Timothy Lukas ,  William Brett Caldwell ,  Dwayne Thomas Friesen ,  David Keith Lyon ,  Christopher Donovan Craig

IPC分类号： A61K31/496 ,  A61P25/00 ,  A61K31/724 ,  A61K31/717 ,  A61K9/22

CPC分类号： A61K31/496

摘要： The present invention provides methods, dosage forms and kits for treating with an effective amount of ziprasidone a CNS disorder in a human when the human is in a fasted state. In one embodiment, the invention relates to a method for treating a CNS disorder in a human, which method comprises administering to the human in a fasted state, a solid oral dosage form comprising an amount of ziprasidone effective to treat said CNS disorder, wherein the area under the serum concentration versus time curve (AUC0-inf) of the ziprasidone in the human subsequent to said administering is from 70% to 140% of the mean area under the ziprasidone serum concentration versus time curve (AUC0-inf) resulting from administration of a control ziprasidone immediate release oral capsule containing the same amount of ziprasidone to a cohort of humans in a fed state.

摘要翻译： 本发明提供了当人处于禁食状态时用人体中有效量的齐拉西酮治疗CNS病症的方法，剂型和试剂盒。 在一个实施方案中，本发明涉及一种用于治疗人类中枢神经系统疾病的方法，所述方法包括以禁食状态对人施用包含有效治疗所述CNS病症的量的齐拉西酮的固体口服剂型，其中 在所述给药之后，人体中齐拉西酮的血清浓度对时间曲线（AUC 0-inf）下的面积是由给药引起的齐拉西酮血清浓度对时间曲线（AUC 0-inf）的平均面积的70％至140％ 的控释齐拉昔酮立即释放口服胶囊含有相同数量的齐拉西酮至饲喂状态的人群。

公开(公告)号：US20050184175A1

公开(公告)日：2005-08-25

申请号：US10786689

申请日：2004-02-25

申请人： Thomas Wubben ,  Kent Klemme ,  Vernon Gambleton ,  Brandon Carlson ,  William Brett ,  Matthew Miller

发明人： Thomas Wubben ,  Kent Klemme ,  Vernon Gambleton ,  Brandon Carlson ,  William Brett ,  Matthew Miller

IPC分类号： A01M7/00 ,  B05B3/02 ,  B05B3/00 ,  B05B3/14 ,  B05B3/18

CPC分类号： A01M7/0078 ,  A01M7/0053

摘要： Foldable boom inner wings are attached to a boom center frame through a rocker attached to a breakaway hydraulic cylinder pressurized to full stroke and connected to an accumulator. When a wing impacts an object, the impact load is transmitted through the fold cylinder and rocker into the breakaway cylinder. As the breakaway cylinder retracts to allow the wing to pivot, pressure builds in the system in three stages. First pressure builds along an accumulator pressure curve until a relief valve in the hydraulic system actives to initiate the second stage wherein oil is dumped through the relief valve. Thereafter, pressure is again allowed to build along the same accumulator curve to absorb impact hydraulically before the cylinder reaches full stroke. The staged pressure buildup prevents boom momentum from gaining and loads from increasing above the strength of the overall structure.

摘要翻译： 可折叠起重臂内翼通过连接到加压到全行程的分离式液压缸的摇臂连接到起重臂中心架，并连接到蓄能器。 当机翼撞击物体时，冲击载荷通过折叠缸和摇杆传递到分离缸中。 当分离式气缸缩回以允许机翼枢转时，压力在三个阶段内建立在系统中。 第一压力沿着蓄能器压力曲线建立，直到液压系统中的安全阀活动以启动第二阶段，其中油通过安全阀倾倒。 此后，再次允许压力沿着相同的蓄能器曲线建立，以在气缸达到全行程之前液压吸收冲击。 分段压力累积可以防止起重臂动量的增加和负载从整体结构的强度增加。

公开(公告)号：US06851943B1

公开(公告)日：2005-02-08

申请号：US10052587

申请日：2002-01-17

申请人： William Brett Novosat

发明人： William Brett Novosat

IPC分类号： B29C35/16 ,  B29C51/10 ,  B29C51/18 ,  B29C43/22

CPC分类号： B29C51/10 ,  B29C35/16 ,  B29C51/18 ,  B29C2791/006 ,  B29C2791/007 ,  Y10S425/047

摘要： A pressure box for thermoforming a heated sleet of thermoforming material against a mold includes a top plate, side plates, a downstream and plate and an upstream end plate. Each end plate includes a pair of plate members that define a slot open to the bottom of the end plate. A sheet strip of elastomeric material is mechanically held in the slot and extends below the end wall to a seal surface. The seal surface is laser cut to closely conform with the three-dimensional shape of the mold.

摘要翻译： 用于将加热的热成型材料的热成型材料热模塑成型的压力盒包括顶板，侧板，下游板和上游端板。 每个端板包括限定通向端板底部开口的槽的一对板构件。 弹性体材料片材机械地保持在槽中并在端壁下方延伸到密封表面。 密封表面被激光切割以与模具的三维形状紧密地一致。