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公开(公告)号：US07618807B2
公开(公告)日：2009-11-17
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译： 本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。 本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。 本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。 典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。 本发明还涉及用于执行该方法的装置。
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公开(公告)号：US20080020450A1
公开(公告)日：2008-01-24
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： C12M1/42
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译： 本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。 本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。 本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。 典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。 本发明还涉及用于执行该方法的装置。
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公开(公告)号：US20050074890A1
公开(公告)日：2005-04-07
申请号：US10848775
申请日：2004-05-18
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译： 本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。 本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。 本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。 典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。 本发明还涉及用于执行该方法的装置。
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公开(公告)号：US20070026515A1
公开(公告)日：2007-02-01
申请号：US11540095
申请日：2006-09-29
申请人： Steven Newman , Brian Kram , Terry Hubbard
发明人： Steven Newman , Brian Kram , Terry Hubbard
IPC分类号： C12M3/00
CPC分类号： A61K9/0024 , A61F2/022
摘要： A biologically implantable containment device having a wet seal, the device being adaptable for drug formulations or cell suspensions. A porous membrane, in a tubular configuration, is formed and can be configured as part of a closed cell-tight system for loading. During loading, the containment device membrane is wet, while the loading system remains cell-tight. The containment device is wet-sealed through a combination of heat and pressure, while the system remains cell-tight. Sealing the containment device substantially or completely eliminates metabolic functioning of any organisms in the vicinity of the closure. The wet-seal is formed by melting a thermoplastic material that is in contact with the membrane. The containment device is separated from the cell-tight loading system, which remains closed after separation.
摘要翻译： 具有湿密封的生物可植入的容纳装置，该装置适用于药物制剂或细胞悬液。 形成管状构造的多孔膜，并且可以构造成用于装载的密闭密闭系统的一部分。 在装载过程中，容纳装置膜是湿的，而装载系统保持细胞密封。 密封装置通过热和压力的组合进行湿式密封，同时系统保持细胞密封。 封闭容器基本上或完全消除封闭物附近任何生物体的代谢功能。 通过熔化与膜接触的热塑性材料形成湿密封。 密封装置与牢固的装载系统分开，分离后保持关闭。
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公开(公告)号：US20070141711A1
公开(公告)日：2007-06-21
申请号：US11639586
申请日：2006-12-15
申请人： Randy Stephens , Brian Kram
发明人： Randy Stephens , Brian Kram
IPC分类号： G01N35/00
CPC分类号： G01N1/312 , G01N1/06 , G01N1/286 , G01N35/00722 , G01N2001/2873 , G01N2035/00861 , G01N2035/00881 , Y10T436/11
摘要： An embodiment of the method of the invention is a method of automating information flow in a laboratory performing tissue staining comprising positioning a networked label printer adjacent to a cutting station, the printer configured to access patient data directly or indirectly from the hospital LIS, the printer being configured with a data element scanner in electronic communication with said printer; inputting data from a tissue cassette-associated data element at said printer, whereby inputting data comprises reading the data from the cassette-associated data element and uploading the cassette data to the LIS; identifying the corresponding test protocol identifier and then downloading the test protocol data to the printer; printing information on labels corresponding to each test specified in the LIS for the patient; attaching a single label to each slide; and cutting a tissue section for each labeled slide and mounting the section on the slide.
摘要翻译： 本发明方法的一个实施例是一种在执行组织染色的实验室中自动化信息流的方法，包括将联网的标签打印机邻近切割站定位，所述打印机被配置为直接或间接地从医院LIS访问患者数据，打印机 配置有与所述打印机电子通信的数据元素扫描器; 从所述打印机的与纸巾相关联的数据元素输入数据，由此输入数据包括从所述盒相关数据元素读取数据并将所述盒数据上传到所述LIS; 识别相应的测试协议标识符，然后将测试协议数据下载到打印机; 在针对患者的LIS中指定的每个测试对应的标签上打印信息; 在每张幻灯片上贴上单个标签; 并切割每个标记的滑块的组织部分并将该部分安装在载玻片上。
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公开(公告)号：US20060134732A1
公开(公告)日：2006-06-22
申请号：US11284397
申请日：2005-11-18
CPC分类号： G01N1/30
摘要： The invention is directed to methods and compositions for deparaffinizing paraffin-embedded biological samples for subsequent tissue staining. The compositions are microemulsions that may include water/oil/surfactant microemulsions, and optionally a cosurfactant. The microemulsions enable deparaffinization without the use of xylene or toluene, and also enable solvent exchange without the use of intermediary alcohol dehydration or alcohol rehydration compositions.
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7.发明申请Method and apparatus for efficient thin film fluid processing of flat surfaces 有权用于平面表面有效薄膜流体处理的方法和装置公开(公告)号：US20050164374A1
公开(公告)日：2005-07-28
申请号：US11016407
申请日：2004-12-17
申请人： Brian Kram
发明人： Brian Kram
CPC分类号： G01N1/312 , B01L3/508 , B01L2200/0642 , B01L2200/0684 , B01L2300/0822 , G01N1/2813 , G01N2035/00158
摘要： A method and apparatus for thin film fluid processing of biological samples without rinsing between treatments is provided. An apparatus having a treatment zone for treating a biological sample with a liquid reagent, comprising first and second substrates having facing surfaces defining a space therebetween in which the biological sample may be treated with the liquid reagent, wherein the first substrate comprises a relatively fluid impermeable element while the second substrate comprises a relatively flexible gas permeable element.
摘要翻译： 提供了一种在处理之间没有漂洗的生物样品的薄膜流体处理方法和装置。 一种具有用于用液体试剂处理生物样品的处理区的设备，包括具有限定其间的空间的面对表面的第一和第二基底，其中可用液体试剂处理生物样品，其中第一基底包括相对流体不渗透性 而第二衬底包括相对柔性的气体可渗透元件。
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