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公开(公告)号：US20120270809A1
公开(公告)日：2012-10-25
申请号：US13477843
申请日：2012-05-22
申请人： Y. Tom Tang , Preeti Lal , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra Patterson , Gina A. Gorgone , Matthew R. Kaser , Mariah R. Baughn , Janice Au-Young
发明人： Y. Tom Tang , Preeti Lal , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra Patterson , Gina A. Gorgone , Matthew R. Kaser , Mariah R. Baughn , Janice Au-Young
IPC分类号： C07K14/435 , G01N33/566 , C07K17/00 , A61K38/17 , C07K16/18
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K2317/24 , C07K2317/622 , C07K2317/76 , G01N33/68
摘要： The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
摘要翻译： 本发明提供了人跨膜蛋白（HTMPN）和识别和编码HTMPN的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与HTMPN表达相关的障碍的方法。
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公开(公告)号：US08206947B2
公开(公告)日：2012-06-26
申请号：US11594148
申请日：2006-11-08
申请人： Y. Tom Tang , Preeti G. Lal , Jennifer L. Jackson , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra S. Arvizu , Gina A. Gorgone Simone , Matthew R. Kaser , Mariah R. Baughn , Janice K. Au-Young
发明人： Y. Tom Tang , Preeti G. Lal , Jennifer L. Jackson , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra S. Arvizu , Gina A. Gorgone Simone , Matthew R. Kaser , Mariah R. Baughn , Janice K. Au-Young
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K2317/24 , C07K2317/622 , C07K2317/76 , G01N33/68
摘要： The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
摘要翻译： 本发明提供了人跨膜蛋白（HTMPN）和识别和编码HTMPN的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与HTMPN表达相关的障碍的方法。
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3.发明申请METHODS AND MATERIALS RELATING TO CD84-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开与CD84-样多肽和多核苷酸相关的方法和材料公开(公告)号：US20110268724A1
公开(公告)日：2011-11-03
申请号：US13179183
申请日：2011-07-08
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： A61K39/395 , C12P21/02 , A61K31/7088 , A61P35/00 , A61P37/06 , A61P29/00 , A61P17/06 , A61P1/00 , G01N33/53 , A61P31/12
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸及其突变体或变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。
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4.发明授权Methods and compositions concerning antibodies that bind CD84-like polypeptides 有权关于结合CD84样多肽的抗体的方法和组合物公开(公告)号：US07981413B2
公开(公告)日：2011-07-19
申请号：US12195282
申请日：2008-08-20
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： A61K39/395
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸及其突变体或变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。
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5.发明申请公开(公告)号：US20100305003A1
公开(公告)日：2010-12-02
申请号：US12590442
申请日：2009-11-05
申请人： Y. Tom Tang
发明人： Y. Tom Tang
CPC分类号： A61K38/16 , C07K14/47 , C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
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公开(公告)号：US20100099617A1
公开(公告)日：2010-04-22
申请号：US12585371
申请日：2009-09-14
申请人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder K. Chawla , Madhusudan M. Sanjanwala , Michael B. Thornton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
发明人： Henry Yue , Monique G. Yao , Ameena R. Gandhi , Mariah R. Baughn , Anita Swarnakar , Narinder K. Chawla , Madhusudan M. Sanjanwala , Michael B. Thornton , Vicki S. Elliott , Yan Lu , Kimberly J. Gietzen , Neil Burford , Li Ding , April J. A. Hafalia , Y. Tom Tang , Olga Bandman , Bridget A. Warren , Cynthia D. Honchell , Dyung Aina M. Lu , Kavitha Thangavelu , Sally Lee , Yuming Xu , Junming Yang , Preeti G. Lal , Bao Tran , Craig H. Ison , Brendan M. Duggan , Stephanie K. Sapperstein
IPC分类号： A61K38/16 , C07K14/00 , A61K38/22 , C07K14/575 , A61P35/00 , A61P29/00 , A61P37/00 , A61P25/00 , A61P9/00 , C12P21/02
CPC分类号： C12N15/1055 , A61K39/3955 , A61K47/64 , A61K47/643 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K14/4713 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/5023
摘要： The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
摘要翻译： 本发明提供鉴定和编码SECP的人分泌蛋白（SECP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与SECP异常表达相关的疾病的方法。
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7.发明申请Methods and Materials Relating to CD84-like Polypeptides and Polynucleotides 审中-公开与CD84样多肽和多核苷酸相关的方法和材料公开(公告)号：US20080260747A1
公开(公告)日：2008-10-23
申请号：US12100870
申请日：2008-04-10
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸和突变体或其变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。
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8.发明申请Methods and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides 审中-公开与新型干细胞生长因子样多肽和多核苷酸相关的方法和材料公开(公告)号：US20080241207A1
公开(公告)日：2008-10-02
申请号：US11985996
申请日：2007-11-19
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： A61L27/54 , C12Q1/68 , C07K16/22 , C12N5/02 , G01N33/53 , C40B40/08 , A61P43/00 , A61K35/12 , A61K38/18 , A61K31/711 , C12N5/00 , C12N5/22
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列 （Hyseq克隆鉴定号13804756,13687487,13804756）。 本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。
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公开(公告)号：US20080200388A1
公开(公告)日：2008-08-21
申请号：US12080212
申请日：2008-04-01
申请人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
IPC分类号： A61K38/16 , C07H21/04 , C12N15/00 , C12N5/00 , C07K14/00 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/00 , C12N5/02
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
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10.发明授权公开(公告)号：US07411052B2
公开(公告)日：2008-08-12
申请号：US10488423
申请日：2002-08-30
申请人： Y. Tom Tang
发明人： Y. Tom Tang
CPC分类号： C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
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