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    COMPOUNDS AND PEPTIDES THAT BIND THE KGF RECEPTOR
    4.
    发明申请
    COMPOUNDS AND PEPTIDES THAT BIND THE KGF RECEPTOR 审中-公开
    使KGF受体结合的化合物和肽

    公开(公告)号：US20090042802A1

    公开(公告)日：2009-02-12

    申请号：US12143684

    申请日：2008-06-20

    Applicant: YIJUN PAN ,  Christopher Holmes ,  Yvonne Angell

    Inventor： YIJUN PAN ,  Christopher Holmes ,  Yvonne Angell

    IPC: A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64

    CPC classification number: C07K14/50 ,  A61K38/00 ,  C07K2319/74

    Abstract: The present invention relates to peptide compounds that bind the KGF receptor. The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with defective or insufficient epithelial cell proliferation. Pharmaceutical compositions, which comprise the peptide compounds of the invention, and dosages are also provided.

    Abstract translation: 本发明涉及结合KGF受体的肽化合物。 本发明还涉及使用这些肽化合物治疗与有缺陷或不足的上皮细胞增殖相关的疾病的治疗方法。 还提供了包含本发明的肽化合物的药物组合物和剂量。

    NITROGEN-BASED LINKERS FOR ATTACHING MODIFYING GROUPS TO POLYPEPTIDES AND OTHER MACROMOLECULES
    5.
    发明申请
    NITROGEN-BASED LINKERS FOR ATTACHING MODIFYING GROUPS TO POLYPEPTIDES AND OTHER MACROMOLECULES 有权
    用于连接改性聚氨酯和其他大分子的基于氮的连接

    公开(公告)号：US20090048147A1

    公开(公告)日：2009-02-19

    申请号：US12022926

    申请日：2008-01-30

    Applicant: Christopher P. Holmes ,  Anjan Chakrabarti ,  Brian T. Frederick ,  Yijun Pan ,  Yaohua S. Dong ,  Ashok Bhandari

    Inventor： Christopher P. Holmes ,  Anjan Chakrabarti ,  Brian T. Frederick ,  Yijun Pan ,  Yaohua S. Dong ,  Ashok Bhandari

    IPC: C07C233/05 ,  C07C229/04 ,  C07K7/02 ,  A61K38/02

    CPC classification number: C07K14/505 ,  C07D207/452 ,  C07D207/46

    Abstract: The present invention relates to a compound comprising a peptide moiety, a linker moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The linker moiety is between the peptide moiety and the water-soluble polymer moiety. In certain embodiments, the linker moiety has the structure: wherein α, β, and γ are each integers whose values are independently selected. In other embodiments the linker moiety has the following structure: wherein κ, ρ, and τ are each integers whose values are independently selected. In other embodiments the linker moiety has the following structure: wherein χ, φ, γ, and η are each integers whose values are independently selected. Alternatively, the linker structure may have the following structure: wherein λ and μ are each integers whose values are independently selected.

    Abstract translation: 本发明涉及包含肽部分，接头部分和水溶性聚合物部分如聚（乙二醇）部分的化合物。 接头部分在肽部分和水溶性聚合物部分之间。 在某些实施方案中，接头部分具有以下结构：其中α，β和γ各自是其值被独立选择的整数。 在其它实施方案中，接头部分具有以下结构：其中kappa，rho和tau各自是其值被独立选择的整数。 在其它实施方案中，接头部分具有以下结构：其中chi，phi，γ和eta各自是其值被独立选择的整数。 或者，连接体结构可以具有以下结构：其中λ和mu各自是其值被独立选择的整数。

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