公开(公告)号：US08703627B2

公开(公告)日：2014-04-22

申请号：US10480744

申请日：2002-06-12

申请人： Shojiro Matsuda ,  Yoshimi Tanaka ,  Yoshito Ikada

发明人： Shojiro Matsuda ,  Yoshimi Tanaka ,  Yoshito Ikada

IPC分类号： B32B27/04 ,  B32B27/12

CPC分类号： A61L31/148 ,  A61L31/045 ,  A61L31/129 ,  Y10T428/1362 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T442/2525 ,  Y10T442/45

摘要： An antiadhesive material that is excellent in biocompatibility and bioabsorbability, as well as excellent strength in suturing and bonding, is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so that the reinforcing material 12 is impregnated with the solution, and the gelatin is caused to gelate and dried. By so doing, an antiadhesive material in which a gelatin film 11 and the reinforcing material 12 are integrated is obtained. The reinforcing material 12 preferably is arranged in a portion of the gelatin film 11 to be subjected to suturing, and preferably is arranged along a periphery of the gelatin film 11. The gelatin film 11 preferably is a cross-linked gelatin film, and the reinforcing material 12 preferably is a nonwoven fabric.

摘要翻译： 提供了生物相容性和生物吸收性优异，以及优异的缝合和粘合强度的防粘附材料。 将由可生物降解的聚合物制成的增强材料12放置在明胶溶液中，使得增强材料12被溶液浸渍，并使明胶凝胶化并干燥。 通过这样做，获得其中将明胶膜11和增强材料12一体化的防粘附材料。 增强材料12优选布置在明胶膜11的一部分中以进行缝合，并且优选沿着明胶膜11的周边布置。明胶膜11优选为交联明胶膜，并且增强 材料12优选为无纺布。

公开(公告)号：US20090143287A1

公开(公告)日：2009-06-04

申请号：US12065979

申请日：2006-09-05

申请人： Yoshito IKADA ,  Shigehiko SUZUKI ,  Tsuguyoshi TAIRA ,  Yoshitake TAKAHASHI ,  Kenji TOMIHATA

发明人： Yoshito IKADA ,  Shigehiko SUZUKI ,  Tsuguyoshi TAIRA ,  Yoshitake TAKAHASHI ,  Kenji TOMIHATA

IPC分类号： A61K38/18 ,  A61K47/42

CPC分类号： A61L27/54 ,  A61L27/26 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L2300/414 ,  A61L2300/602 ,  C08L89/06

摘要： The present invention provides a tissue regeneration substrate that has the ability to release a basic fibroblast growth factor (bFGF) and like cell growth factors in a sustained manner, into which cells can easily enter, and that is suitably used for regeneration of tissues. Specifically, the present invention provides a tissue regeneration substrate that comprises a cell growth factor adsorbed in a bioabsorbable porous substrate that contains collagen and gelatin, and a method for producing the same.

摘要翻译： 本发明提供一种组织再生底物，其能够以持续的方式释放碱性成纤维细胞生长因子（bFGF）等细胞生长因子，细胞容易进入细胞生长因子，适合用于组织的再生。 具体而言，本发明提供一种组织再生基板，其包含吸附在含有胶原和明胶的生物可吸收性多孔基材中的细胞生长因子及其制造方法。

公开(公告)号：US4727030A

公开(公告)日：1988-02-23

申请号：US791274

申请日：1985-10-25

申请人： Fumihiro Ishimura ,  Koji Murata ,  Suong-Hyu Hyon ,  Yoshito Ikada

发明人： Fumihiro Ishimura ,  Koji Murata ,  Suong-Hyu Hyon ,  Yoshito Ikada

IPC分类号： C12N11/08 ,  C12N11/04 ,  C12N11/02 ,  C12N11/14

CPC分类号： C12N11/04

摘要： A porous gel containing an immobilized enzyme is prepared by mixing an aqueous solution of polyvinyl alcohol having a saponification degree of not lower than 95 mol% and an average polymerization degree of not lower than 1,000, with an enzyme or enzyme-producing cell, and activated carbon powder, pouring the mixture into a container of any desired form, gelating and molding the mixture by dehydrating it up to a dehydration ratio of not lower than 50%, immersing the resulting molding in water, and drying the immersed molding. Preferably, dehydrating is by leaving the mixture to stand at room temperature or a temperature of from 30.degree. C. to 40.degree. C. The enzyme or enzyme-producing cell may be mixed with or adsorbed on an inorganic or organic carrier. The dried molding may be granulated.

摘要翻译： 通过将皂化度不低于95摩尔％且平均聚合度不低于1,000的聚乙烯醇水溶液与酶或酶产生细胞混合并制备含有固定化酶的多孔凝胶，并将其活化 碳粉，将混合物倒入任何所需形式的容器中，通过将其脱水至脱水率不低于50％，将混合物凝胶化和模塑，将所得模制品浸入水中，并干燥浸渍的模制品。 优选地，脱水是通过在室温或30℃至40℃的温度下使混合物静置。酶或酶产生细胞可以与无机或有机载体混合或吸附在无机或有机载体上。 干燥的成型品可以造粒。

公开(公告)号：US4663358A

公开(公告)日：1987-05-05

申请号：US855929

申请日：1986-04-25

申请人： Suong-Hyu Hyon ,  Yoshito Ikada

发明人： Suong-Hyu Hyon ,  Yoshito Ikada

IPC分类号： C08L29/04 ,  B01J13/00 ,  C08J3/03 ,  C08J9/28 ,  C08L29/00 ,  C08L29/02

CPC分类号： C08J9/28 ,  C08J3/075 ,  C08J2329/04

摘要： A porous and transparent hydrated gel is prepared from a poly(vinyl alcohol) solution in a mixed solvent consisting of water and an water-miscible organic solvent. Upon cooling the poly(vinyl alcohol) solution below room temperature, a gel is formed as a consequence of crystallization of poly(vinyl alcohol) molecules. Exchange of the organic solvent included in the gel with water produces a hydrated gel of poly(vinyl alcohol) which has a high tensile strength, a high water content, and a high light transmittance.

摘要翻译： 由聚（乙烯醇）溶液在由水和水混溶性有机溶剂组成的混合溶剂中制备多孔和透明的水合凝胶。 在将聚（乙烯醇）溶液冷却至室温以下时，由于聚（乙烯醇）分子的结晶而形成凝胶。 将凝胶中包含的有机溶剂与水的交换产生具有高拉伸强度，高含水量和高透光率的聚（乙烯醇）的水合凝胶。

公开(公告)号：US06846330B2

公开(公告)日：2005-01-25

申请号：US10310521

申请日：2002-12-05

申请人： Koji Yamauchi ,  Yoshito Ikada ,  Susumu Miyamoto ,  Keisuke Yamada ,  Tomohiko Asahara

发明人： Koji Yamauchi ,  Yoshito Ikada ,  Susumu Miyamoto ,  Keisuke Yamada ,  Tomohiko Asahara

IPC分类号： A61L27/18 ,  A61L27/58 ,  A61F2/02 ,  C08L6/08

CPC分类号： A61L27/58 ,  A61L27/18 ,  C08L67/04

摘要： The present invention provides an artificial dura mater characterized by comprising at least a sheet of a biodegradable and bioabsorbable synthetic polymer and having a storage modulus at ordinary temperature of from 1×107 to 5×108 (Pa); and a process for producing an artificial dura mater characterized by dissolving a lactide/ε-caprolactone copolymer (in a molar ratio ranging from 40/60 to 60/40) in a solvent, filtering the resultant solution and casting the same followed by air drying.

摘要翻译： 本发明提供了一种人造硬膜，其特征在于包括至少一片生物可降解和生物可吸收的合成聚合物，并且在常温下为1×10 7至5×10 8（Pa）的储能模量; 以及用于制备人造硬膜的方法，其特征在于将溶剂中的丙交酯/ε-己内酯共聚物（摩尔比为40/60至60/40）溶解在溶剂中，过滤所得溶液并浇铸，然后进行空气干燥 。

公开(公告)号：US5800545A

公开(公告)日：1998-09-01

申请号：US776643

申请日：1997-02-05

申请人： Shiro Yamada ,  Yoshito Ikada

发明人： Shiro Yamada ,  Yoshito Ikada

IPC分类号： A61F2/10 ,  A61L27/34

CPC分类号： A61F2/10 ,  A61L27/34 ,  A61L2430/18

摘要： An artificial hair having a physiologically active surface which is formed by a such manner that protein (collagen) molecules are bonded chemically to the graft-polymerized chains introduced onto the surface of the artificial hair. When the artificial hair is implanted into a human body skin, the collagen layer 11 fixed to the surface of the artificial hair having a root part 12 is integrally assimilated and bonded to collagens in the epidermis 4, the corium layer 5, the subcutaneous tissue 6 and the galea 7, whereby the artificial hair can be firmly fixed. Thus, this artificial hair exhibits a low infection rate, a high success rate and cannot be accompanied by down-growth phenomenon.

摘要翻译： PCT No.PCT / JP96 / 01501 Sec。 371日期1997年2月5日 102（e）1997年2月5日PCT PCT 1996年6月4日PCT公布。 WO96 / 40301 PCT出版物 日本1996年12月19日具有生理活性表面的人造毛发，其通过使蛋白质（胶原）分子与引入人造毛发表面的接枝聚合链化学键合而形成。 当将人造毛发植入人体皮肤时，固定在具有根部12的人造毛发的表面上的胶原层11被整体地吸收并结合到表皮4，corium层5，皮下组织6中的胶原 和甘露7，由此人造头发可以牢固地固定。 因此，这种人造毛发感染率低，成功率高，不能伴随下降生长现象。

公开(公告)号：US5707643A

公开(公告)日：1998-01-13

申请号：US665047

申请日：1996-06-07

申请人： Yuichiro Ogura ,  Yoshito Ikada

发明人： Yuichiro Ogura ,  Yoshito Ikada

IPC分类号： A61B17/00 ,  A61F9/00 ,  A61F9/007 ,  A61M31/00 ,  A61F2/14

CPC分类号： A61M31/002 ,  A61F9/0017 ,  A61F9/00781 ,  A61K9/0051 ,  A61B17/0057 ,  A61B2017/00004

摘要： The present invention relates to a scleral plug made of lactic acid copolymer; a scleral plug containing a drug that is designed to gradually release the drug into a vitreous body; and a scleral plug that is used to treat or prevent diseases of the retina or to promote recovery from damage after vitreous surgery taking advantage of its sustained release action for drug delivery.

摘要翻译： 本发明涉及由乳酸共聚物制成的巩膜塞; 一种含有药物的巩膜塞，其设计用于逐渐将药物释放到玻璃体中; 以及用于治疗或预防视网膜疾病的巩膜塞，或者利用其药物递送的持续释放作用促进玻璃体手术后的损伤恢复。

公开(公告)号：US5486606A

公开(公告)日：1996-01-23

申请号：US057094

申请日：1993-05-04

申请人： Shingo Emi ,  Kyoji Suzuki ,  Yoshito Ikada

发明人： Shingo Emi ,  Kyoji Suzuki ,  Yoshito Ikada

IPC分类号： A61L33/00 ,  A61M1/18 ,  B01D67/00 ,  B01D71/12 ,  B01D71/22 ,  C08B11/14 ,  C08B11/145 ,  C08B11/15 ,  C08B15/06 ,  C08L1/00 ,  C08L1/08 ,  B01D61/24 ,  B01D61/28

CPC分类号： B01D67/0093 ,  B01D71/12 ,  B01D71/22 ,  C08B11/14 ,  C08B11/15 ,  C08B15/06

摘要： A cellulosic polymer wherein at least a part of the hydroxyl groups of the cellulosic polymer is modified as represented by the following general formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a C.sub.1 to C.sub.5 alkyl group, X is a strong negative atomic group, and Y is ##STR2## wherein R.sup.3 and R.sup.4 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group and a C.sub.3 to C.sub.6 cycloalkyl group, or ##STR3## Y is wherein R.sup.5, R.sup.6 and R.sup.7 may be the same or different and each represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, a C.sub.3 to C.sub.6 cycloalkyl group and a C.sub.6 to C.sub.10 aryl group, and n is from 1 to 10. Using the cellulosic polymer, a blood-treating device is assembled.

摘要翻译： 一种纤维素聚合物，其中纤维素聚合物的至少一部分羟基被改性，如以下通式[I]表示：其中R 1和R 2可以相同或不同，并且各自表示氢 原子或C1〜C5烷基，X为强负极性原子团，Y为<，其中R3和R4可以相同或不同，各自表示选自氢原子，C1 C5烷基和C3-C6环烷基，或者Y是其中R5，R6和R7可以相同或不同，并且各自表示选自氢原子，C1-C5烷基 基团，C3至C6环烷基和C6至C10芳基，n为1至10.使用纤维素聚合物组装血液处理装置。

公开(公告)号：US5298243A

公开(公告)日：1994-03-29

申请号：US422701

申请日：1989-10-17

申请人： Yoshito Ikada ,  Yasuhiko Tabata ,  Hiroyasu Suzuki

发明人： Yoshito Ikada ,  Yasuhiko Tabata ,  Hiroyasu Suzuki

IPC分类号： A61K38/19 ,  A61K47/48 ,  C07K15/00 ,  C07K3/02

CPC分类号： A61K38/193 ,  A61K47/48292

摘要： Disclosed are a crosslinked gelatin microspheres containing CSF and a water soluble CSF-gelatin conjugate. Both the microspheres and the water soluble conjugate provide an improved CSF stability. They have a high potentiation on the antitumor activity of macrophages in respect of the CSF amount and the time required for macrophage activation and are effective in maintaining their activated state for a long period, compared with the native CSF. The mechanism of macrophage activation by the microspheres containing CSF is mediated via phagocytosis and different from that by native CSF, which is believed to activate macrophages via cell surface receptor. The species specificity of CSF may be abrogated when the CSF is internalized into macrophages through phagocytosis.

摘要翻译： 公开了含有CSF和水溶性CSF-明胶缀合物的交联明胶微球。 微球和水溶性缀合物都能提供改善的CSF稳定性。 与天然CSF相比，它们对于巨噬细胞的CSF量和巨噬细胞活化所需的时间对抗巨噬细胞的抗肿瘤活性具有高增强作用，并且与天然CSF相比长效保持其活化状态是有效的。 通过含有CSF的微球的巨噬细胞活化的机制是通过吞噬作用介导的，不同于被认为通过细胞表面受体激活巨噬细胞的天然CSF。 当CSF通过吞噬作用内化于巨噬细胞时，CSF的物种特异性可能被消除。

公开(公告)号：US5250584A

公开(公告)日：1993-10-05

申请号：US915770

申请日：1992-07-21

申请人： Yoshito Ikada ,  Shokyu Gen

发明人： Yoshito Ikada ,  Shokyu Gen

IPC分类号： A61K6/00 ,  A61K9/00 ,  A61K31/765 ,  A61L27/18 ,  A61L27/58 ,  A61F2/00 ,  C08G63/08

CPC分类号： A61L27/58 ,  A61K31/765 ,  A61K6/0032 ,  A61K9/0063 ,  A61L27/18 ,  Y10S623/924

摘要： A periodontium-regenerating material for the regenerative treatment of the periodontium consists of bio-degradable/absorable copolymers of lactide/.epsilon.-caprolactone or lactide/glycolide having a weight-average molecular weight of 40,000 to 500,000 as well as a dynamic modulus of 5.times.10.sup.7 to 5.times.10.sup.9 dynes/cm.sup.2 and a elongation rate of 100 to 2,000 %, both measured at room temperature (25.degree. C.). Those copolymers may be used in the form of a sheet or film which may or may not be porous.

摘要翻译： 用于牙周组织的再生治疗的牙周膜再生材料由重均分子量为40,000至500,000的丙交酯/ε-己内酯或丙交酯/乙交酯的生物降解/吸收共聚物以及5×10 7至 5×10 9达因/ cm2，伸长率为100〜2000％，均在室温（25℃）下测定。 这些共聚物可以以可以是或不是多孔的片或薄膜的形式使用。