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公开(公告)号：US08026110B2
公开(公告)日：2011-09-27
申请号：US11853594
申请日：2007-09-11
申请人： Young-Tae Chang , Young-Hoon Ahn
发明人： Young-Tae Chang , Young-Hoon Ahn
CPC分类号： C07D219/06 , C07D311/68 , C07D311/86 , C07D335/16 , C07D401/04 , C07D471/22 , G01N33/583 , Y10S436/80 , Y10T436/142222 , Y10T436/145555
摘要： The present invention relates to a rosamine derivative compound, as described herein, having the following structure: Also disclosed are methods of making such compounds and for using them for detection and imaging.
摘要翻译： 本发明涉及如本文所述的具有以下结构的rosamine衍生物化合物：还公开了制备这些化合物并用于检测和成像的方法。
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公开(公告)号：US20080203353A1
公开(公告)日：2008-08-28
申请号：US12013975
申请日：2008-01-14
申请人： Hae Seok JI , Ook Jae Cho , Jae Gug Ryu , Jong Yeol Yang , Young Hoon Ahn , Bong Suk Kim , Dong Hyun Kim
发明人： Hae Seok JI , Ook Jae Cho , Jae Gug Ryu , Jong Yeol Yang , Young Hoon Ahn , Bong Suk Kim , Dong Hyun Kim
IPC分类号： C09K13/00
CPC分类号： C07C17/208 , C07C17/38 , C07C17/383 , C07C23/08
摘要： The invention is a method for continuously preparing highly pure octafluorocyclopentene for use in dry-etching processes. The method includes reacting octachlorocyclopentene with KF in a continuous manner, and purifying crude octafluorocyclopentene. In the reacting step, two KF-charged filters are installed in parallel and allowed to communicate with a reactor containing octachlorocyclopentene in an alternating manner to produce crude octafluorocyclopentene. In the purifying step, organics having lower boiling points than octafluorocyclopentene are removed, and metal ingredients and organics having boiling points higher than octafluorocyclopentene are separated to recover octafluorocyclopentene as a gas. The gaseous octafluorocyclopentene composition contains C5F8 in an amount of 99.995 vol % or higher, nitrogen in an amount of 50 vol ppm or less, oxygen in an amount of 5 vol ppm or less, water in an amount of 5 vol ppm or less, and metal ingredients in an amount of 5 wt ppb or less.
摘要翻译： 本发明是用于连续制备用于干蚀刻工艺的高纯度八氟环戊烯的方法。 该方法包括使八氯环戊烯与KF连续反应，并纯化粗八氟环戊烯。 在反应步骤中，平行安装两个带有KF的过滤器，并使其与含有八氯环戊烯的反应器以交替方式连通以产生粗制八氟环戊烯。 在纯化步骤中，除去沸点低于八氟环戊烯的有机物，分离沸点高于八氟环戊烯的金属成分和有机物，以回收作为气体的八氟环戊烯。 气态八氟环戊烯组合物含有99.995体积％以上的C 5 C 5 N 8 N 8，50体积ppm以下的氮，5重量％的氧 体积ppm以下的水，5体积ppm以下的水，5重量ppm以下的金属成分。
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3.发明授权公开(公告)号：US07319174B2
公开(公告)日：2008-01-15
申请号：US11535035
申请日：2006-09-25
申请人： Hae Seok Ji , Ook Jae Cho , Jae Gug Ryu , Jong Yeol Yang , Young Hoon Ahn , Bong Suk Kim , Dong Hyun Kim
发明人： Hae Seok Ji , Ook Jae Cho , Jae Gug Ryu , Jong Yeol Yang , Young Hoon Ahn , Bong Suk Kim , Dong Hyun Kim
CPC分类号： C07C17/208 , C07C17/38 , C07C17/383 , C07C23/08
摘要： The invention is a method for continuously preparing highly pure octafluorocyclopentene for use in dry-etching processes. The method includes reacting octachlorocyclopentene with KF in a continuous manner, and purifying crude octafluorocyclopentene. In the reacting step, two KF-charged filters are installed in parallel and allowed to communicate with a reactor containing octachlorocyclopentene in an alternating manner to produce crude octafluorocyclopentene. In the purifying step, organics having lower boiling points than octafluorocyclopentene are removed, and metal ingredients and organics having boiling points higher than octafluorocyclopentene are separated to recover octafluorocyclopentene as a gas. The gaseous octafluorocyclopentene composition contains C5F8 in an amount of 99.995 vol % or higher, nitrogen in an amount of 50 vol ppm or less, oxygen in an amount of 5 vol ppm or less, water in an amount of 5 vol ppm or less, and metal ingredients in an amount of 5 wt ppb or less.
摘要翻译： 本发明是用于连续制备用于干蚀刻工艺的高纯度八氟环戊烯的方法。 该方法包括使八氯环戊烯与KF连续反应，并纯化粗八氟环戊烯。 在反应步骤中，平行安装两个带有KF的过滤器，并使其与含有八氯环戊烯的反应器以交替方式连通以产生粗制八氟环戊烯。 在纯化步骤中，除去沸点低于八氟环戊烯的有机物，分离沸点高于八氟环戊烯的金属成分和有机物，以回收作为气体的八氟环戊烯。 气态八氟环戊烯组合物含有99.995体积％以上的C 5 C 5 N 8 N 8，50体积ppm以下的氮，5重量％的氧 体积ppm以下的水，5体积ppm以下的水，5重量ppm以下的金属成分。
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公开(公告)号：US08951938B2
公开(公告)日：2015-02-10
申请号：US12340933
申请日：2008-12-22
申请人： Young-Tae Chang , Young-Hoon Ahn , Yun Kyung Kim , Bridget Wagner , Hyman A. Carrinski , Paul Clemons , Stuart Schreiber
发明人： Young-Tae Chang , Young-Hoon Ahn , Yun Kyung Kim , Bridget Wagner , Hyman A. Carrinski , Paul Clemons , Stuart Schreiber
CPC分类号： G01N33/5073 , G01N33/5061 , Y10S436/80
摘要： The present invention relates to the use of rosamine derivative compounds, as described herein, in detecting differentiated forms of a cell type of interest in a sample and in screening for compounds which inhibit differentiation of the cell type of interest. The candidate compound has the following structure:
摘要翻译： 本发明涉及如本文所述的用于检测样品中感兴趣的细胞类型的分化形式以及筛选抑制感兴趣的细胞类型分化的化合物的用途。 候选化合物具有以下结构：
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5.发明授权Methods for detecting embryonic stem cells, induced pluripotent stem cells, or cells undergoing reprogramming to produce induced pluripotent stem cells 有权用于检测胚胎干细胞，诱导多能干细胞或进行重编程以产生诱导多能干细胞的细胞的方法公开(公告)号：US08735150B2
公开(公告)日：2014-05-27
申请号：US13214782
申请日：2011-08-22
申请人： Young-Tae Chang , Hyung Ho Ha , Nam Young Kang , Seong Wook Yun , Sung Jin Park , Young-Hoon Ahn
发明人： Young-Tae Chang , Hyung Ho Ha , Nam Young Kang , Seong Wook Yun , Sung Jin Park , Young-Hoon Ahn
IPC分类号： C12N5/00 , G01N33/567
CPC分类号： G01N33/5073
摘要： The present invention relates to methods of detecting, in a sample, embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods include providing a sample potentially containing such cells and providing a rosamine derivative compound of the formula (I): where the rosamine derivative compound selectively produces fluorescent signals for embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods also include the steps of contacting the sample with the rosamine derivative compound and detecting the presence of the embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells based on fluorescent signals emitted by the sample following said contacting.
摘要翻译： 本发明涉及在样品中检测胚胎干细胞，诱导多能干细胞和/或经历重编程以产生诱导多能干细胞的细胞的方法。 这些方法包括提供潜在地含有这种细胞的样品并提供式（I）的rosamine衍生物化合物：其中所述rosamine衍生物化合物选择性地产生用于胚胎干细胞，诱导多能干细胞和/或经历重编程产生的细胞的荧光信号 诱导多能干细胞。 这些方法还包括以下步骤：使样品与rosamine衍生物化合物接触并检测胚胎干细胞，诱导的多能干细胞和/或经历重编程的细胞的存在，以基于由样品发射的荧光信号产生诱导多能干细胞 接下来说
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公开(公告)号：US07504547B2
公开(公告)日：2009-03-17
申请号：US11797355
申请日：2007-05-02
申请人： Hae-Seok Ji , Ook-Jae Cho , Jae-Gug Ryu , Young-Hoon Ahn , Bong-Suk Kim , Dong-Hyun Kim
发明人： Hae-Seok Ji , Ook-Jae Cho , Jae-Gug Ryu , Young-Hoon Ahn , Bong-Suk Kim , Dong-Hyun Kim
摘要： Disclosed herein is a method of preparing a perfluoroalkadiene. A dihaloperfluorocarbon used as a starting material is added dropwise to a nonpolar organic solvent, a metal powder and an organic metal compound. The dihaloperfluorocarbon is slowly added dropwise in a temperature range from 30° C. to 150° C. for a certain period of time. Moreover, the nonpolar organic solvent used may be benzene, toluene, xylene, etc., and the organic metal compound is used by being dissolved in ethyl ether or tetrahydrofuran at a concentration of 1 to 3M. The metal powder used may be Mg, Zn, Cd, etc.
摘要翻译： 本文公开了一种制备全氟二烯的方法。 将用作起始原料的二卤碳氟化合物滴加到非极性有机溶剂，金属粉末和有机金属化合物中。 在30℃至150℃的温度范围内缓慢滴加二卤氟碳化氢一段时间。 此外，所用的非极性有机溶剂可以是苯，甲苯，二甲苯等，有机金属化合物以1〜3M的浓度溶解于乙醚或四氢呋喃中使用。 使用的金属粉末可以是Mg，Zn，Cd等
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7.发明申请公开(公告)号：US20070265478A1
公开(公告)日：2007-11-15
申请号：US11535035
申请日：2006-09-25
申请人： Hae Seok JI , Ook Jae Cho , Jae Gug Ryu , Jong Yeol Yang , Young Hoon Ahn , Bong Suk Kim , Dong Hyun Kim
发明人： Hae Seok JI , Ook Jae Cho , Jae Gug Ryu , Jong Yeol Yang , Young Hoon Ahn , Bong Suk Kim , Dong Hyun Kim
IPC分类号： C07C17/20
CPC分类号： C07C17/208 , C07C17/38 , C07C17/383 , C07C23/08
摘要： The invention is a method for continuously preparing highly pure octafluorocyclopentene for use in dry-etching processes. The method includes reacting octachlorocyclopentene with KF in a continuous manner, and purifying crude octafluorocyclopentene. In the reacting step, two KF-charged filters are installed in parallel and allowed to communicate with a reactor containing octachlorocyclopentene in an alternating manner to produce crude octafluorocyclopentene. In the purifying step, organics having lower boiling points than octafluorocyclopentene are removed, and metal ingredients and organics having boiling points higher than octafluorocyclopentene are separated to recover octafluorocyclopentene as a gas. The gaseous octafluorocyclopentene composition contains C5F8 in an amount of 99.995 vol % or higher, nitrogen in an amount of 50 vol ppm or less, oxygen in an amount of 5 vol ppm or less, water in an amount of 5 vol ppm or less, and metal ingredients in an amount of 5 wt ppb or less.
摘要翻译： 本发明是用于连续制备用于干蚀刻工艺的高纯度八氟环戊烯的方法。 该方法包括使八氯环戊烯与KF连续反应，并纯化粗八氟环戊烯。 在反应步骤中，平行安装两个带有KF的过滤器，并使其与含有八氯环戊烯的反应器以交替方式连通以产生粗制八氟环戊烯。 在纯化步骤中，除去沸点低于八氟环戊烯的有机物，分离沸点高于八氟环戊烯的金属成分和有机物，以回收作为气体的八氟环戊烯。 气态八氟环戊烯组合物含有99.995体积％以上的C 5 C 5 N 8 N 8，50体积ppm以下的氮，5重量％的氧 体积ppm以下的水，5体积ppm以下的水，5重量ppm以下的金属成分。
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8.发明申请METHODS FOR DETECTING EMBRYONIC STEM CELLS, INDUCED PLURIPOTENT STEM CELLS, OR CELLS UNDERGOING REPROGRAMMING TO PRODUCE INDUCED PLURIPOTENT STEM CELLS 有权检测胚胎干细胞的方法，诱导的细胞干细胞或细胞转染以产生诱导的大脑干细胞公开(公告)号：US20120052505A1
公开(公告)日：2012-03-01
申请号：US13214782
申请日：2011-08-22
申请人： Young-Tae CHANG , Hyung Ho HA , Nam Young KANG , Seong Wook YUN , Sung Jin PARK , Young-Hoon AHN
发明人： Young-Tae CHANG , Hyung Ho HA , Nam Young KANG , Seong Wook YUN , Sung Jin PARK , Young-Hoon AHN
CPC分类号： G01N33/5073
摘要： The present invention relates to methods of detecting, in a sample, embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods include providing a sample potentially containing such cells and providing a rosamine derivative compound of the formula (I): where the rosamine derivative compound selectively produces fluorescent signals for embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods also include the steps of contacting the sample with the rosamine derivative compound and detecting the presence of the embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells based on fluorescent signals emitted by the sample following said contacting.
摘要翻译： 本发明涉及在样品中检测胚胎干细胞，诱导多能干细胞和/或经历重编程以产生诱导多能干细胞的细胞的方法。 这些方法包括提供潜在地含有这种细胞的样品并提供式（I）的rosamine衍生物化合物：其中所述rosamine衍生物化合物选择性地产生用于胚胎干细胞，诱导多能干细胞和/或经历重编程产生的细胞的荧光信号 诱导多能干细胞。 这些方法还包括以下步骤：使样品与rosamine衍生物化合物接触并检测胚胎干细胞，诱导的多能干细胞和/或经历重编程的细胞的存在，以基于由样品发射的荧光信号产生诱导多能干细胞 接下来说
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公开(公告)号：US20090227467A1
公开(公告)日：2009-09-10
申请号：US12340933
申请日：2008-12-22
申请人： Young-Tae CHANG , Young-Hoon AHN , Yun Kyung KIM , Bridget WAGNER , Hyman A. CARRINSKI , Paul CLEMONS , Stuart SCHREIBER
发明人： Young-Tae CHANG , Young-Hoon AHN , Yun Kyung KIM , Bridget WAGNER , Hyman A. CARRINSKI , Paul CLEMONS , Stuart SCHREIBER
IPC分类号： C40B30/04
CPC分类号： G01N33/5073 , G01N33/5061 , Y10S436/80
摘要： The present invention relates to the use of rosamine derivative compounds, as described herein, in detecting differentiated forms of a cell type of interest in a sample and in screening for compounds which inhibit differentiation of the cell type of interest. The candidate compound has the following structure:
摘要翻译： 本发明涉及如本文所述的用于检测样品中感兴趣的细胞类型的分化形式以及筛选抑制感兴趣的细胞类型分化的化合物的用途。 候选化合物具有以下结构：
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公开(公告)号：US20080262195A1
公开(公告)日：2008-10-23
申请号：US11797355
申请日：2007-05-02
申请人： Hae-Seok Ji , Ook-Jae Cho , Jae-Gug Ryu , Young-Hoon Ahn , Bong-Suk Kim , Dong-Hyun Kim
发明人： Hae-Seok Ji , Ook-Jae Cho , Jae-Gug Ryu , Young-Hoon Ahn , Bong-Suk Kim , Dong-Hyun Kim
摘要： Disclosed herein is a method of preparing a perfluoroalkadiene. A dihaloperfluorocarbon used as a starting material is added dropwise to a nonpolar organic solvent, a metal powder and an organic metal compound. The dihaloperfluorocarbon is slowly added dropwise in a temperature range from 30° C. to 150° C. for a certain period of time. Moreover, the nonpolar organic solvent used may be benzene, toluene, xylene, etc., and the organic metal compound is used by being dissolved in ethyl ether or tetrahydrofuran at a concentration of 1 to 3M. The metal powder used may be Mg, Zn, Cd, etc.
摘要翻译： 本文公开了一种制备全氟二烯的方法。 将用作起始原料的二卤碳氟化合物滴加到非极性有机溶剂，金属粉末和有机金属化合物中。 在30℃至150℃的温度范围内缓慢滴加二卤氟碳化氢一段时间。 此外，所用的非极性有机溶剂可以是苯，甲苯，二甲苯等，有机金属化合物以1〜3M的浓度溶解于乙醚或四氢呋喃中使用。 使用的金属粉末可以是Mg，Zn，Cd等。
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