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公开(公告)号：US20200325153A1
公开(公告)日：2020-10-15
申请号：US16872279
申请日：2020-05-11
发明人： Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Katja Jantos , Wilfried Braje , Andreas Kling , Frauke Pohlki , Thomas D. Penning
IPC分类号： C07D495/16 , C07D495/18 , A61K45/06 , C07D495/22 , C07D491/18 , A61K31/519 , C07D491/22 , A61P35/00 , A61P35/02
摘要： The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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公开(公告)号：US20190144465A1
公开(公告)日：2019-05-16
申请号：US15998789
申请日：2018-08-15
发明人： Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Katja Jantos , Wilfried Braje , Andreas Kling , Frauke Pohlki , Thomas D. Penning
IPC分类号： C07D495/16 , A61P35/02
摘要： The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, R15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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公开(公告)号：US20180071262A1
公开(公告)日：2018-03-15
申请号：US15727220
申请日：2017-10-06
申请人： AbbVie Inc.
发明人： Edward A. Kesicki , Arthur F. Kluge , Michael A. Patane , John H. Van Drie, JR. , Ce Wang , Maricel Torrent , Michael L. Curtin , Todd M. Hansen , Rick F. Clark , Robin R. Frey , Zhiqin Ji , Yujia Dai , William J. McClellan , Jane Gong , Gui-dong G. Zhu , Anthony Mastracchio , Michael R. Michaelides , Thomas D. Penning , Chunqiu C. Lai
IPC分类号： A61K31/4184 , C07D498/10 , C07D403/06 , C07D493/10 , C07D491/107 , C07D263/52 , C07D417/12 , C07D417/04 , C07D413/12 , C07D413/04 , C07D409/12 , C07D407/12 , C07D401/12 , C07D235/02 , C07D413/14 , C07D403/12 , C07D409/06 , C07D405/06 , A61K31/423 , A61K31/4439 , C07D401/06 , C07D495/10
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4439 , C07D235/02 , C07D263/52 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D491/107 , C07D493/10 , C07D495/10 , C07D498/10
摘要： Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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公开(公告)号：US09650358B2
公开(公告)日：2017-05-16
申请号：US14207854
申请日：2014-03-13
申请人： AbbVie Inc.
发明人： Anthony Mastracchio , Milan Bruncko , Chunqiu Lai , Julie M. Miyashiro , Zhi-Fu Tao , Keith W. Woods , Thomas D. Penning , Andrew J. Souers
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D453/02 , C07D471/04 , A61K31/4545 , A61K31/4439 , A61K31/5377 , A61K31/444 , A61K31/506 , A61K31/439
CPC分类号： C07D401/04 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D453/02 , C07D471/04
摘要： Disclosed are compound of Formula (Ia), wherein R2, R12, R16, J, Q, X, Y and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (Ia).
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公开(公告)号：US08969375B2
公开(公告)日：2015-03-03
申请号：US14207841
申请日：2014-03-13
申请人： AbbVie Inc.
发明人： Chunqiu Lai , Zhi-Fu Tao , Keith W. Woods , Thomas D. Penning , Andrew J. Souers , Anthony Mastracchio , Julie M. Miyashiro , Yunsong Tong
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , A61K45/06 , C07D487/04 , C07D519/00
摘要： Disclosed are compound of Formula (Ia), wherein R1A, R1, R2, R10, J, L, T, X, Y, and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions, comprising one or more compounds of Formula (Ia).
摘要翻译： 公开了式（Ia）的化合物，其中R 1A，R 1，R 2，R 10，J，L，T，X，Y和Z如说明书中所定义，及其药学上可接受的盐。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还提供了包含一种或多种式（Ia）化合物的药物组合物。
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公开(公告)号：US20130225589A1
公开(公告)日：2013-08-29
申请号：US13773906
申请日：2013-02-22
申请人： AbbVie Inc.
IPC分类号： C07D471/14 , C07D471/04
CPC分类号： C07D471/14 , A61K31/519 , C07D471/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1，R2，R3，R4和B在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US20200010480A1
公开(公告)日：2020-01-09
申请号：US16575114
申请日：2019-09-18
发明人： Patrick B. Brady , Wilfried Braje , Yujia Dai , George A. Doherty , Jane Gong , Katja Jantos , Cheng Ji , Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Anthony Mastracchio , Roberto M. Risi , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Xilu Wang , Michael D. Wendt , Yiyun Yu , Guidong Zhu , Thomas D. Penning
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20190055264A1
公开(公告)日：2019-02-21
申请号：US15998688
申请日：2018-08-15
发明人： Patrick B. Brady , Wilfried Braje , Yujia Dai , George A. Doherty , Jane Gong , Katja Jantos , Cheng Ji , Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Anthony Mastracchio , Roberto M. Risi , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Xilu Wang , Michael D. Wendt , Yiyun Yu , Guidong Zhu , Thomas D. Penning
IPC分类号： C07D498/18 , C07D495/18 , C07D519/00 , A61P35/00
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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![Substituted pyrrolo[2,3-d]pyrimindines as CDK9 kinase inhibitors](/abs-image/US/2016/05/24/US09346813B2/abs.jpg.150x150.jpg)
9.发明授权公开(公告)号：US09346813B2
公开(公告)日：2016-05-24
申请号：US14207868
申请日：2014-03-13
申请人： AbbVie Inc.
发明人： Alan S. Florjancic , Yunsong Tong , Thomas D. Penning , Andrew J. Souers , Rajeev Goswami , Zhi-Fu Tao
IPC分类号： A61K31/519 , C07D239/70 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , A61K2300/00
摘要： Disclosed are compound of Formula (Ia), wherein R1, R2, and R3 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions, comprising one or more compounds of Formula (Ia).
摘要翻译： 公开了式（Ia）的化合物，其中R 1，R 2和R 3如说明书中所定义，及其药学上可接受的盐。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还提供了包含一种或多种式（Ia）化合物的药物组合物。
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公开(公告)号：US09163007B2
公开(公告)日：2015-10-20
申请号：US14136359
申请日：2013-12-20
申请人： AbbVie Inc.
发明人： Irini Akritopoulou-Zanze , Brian D. Wakefield , Helmut Mack , Sean C. Turner , Alan F. Gasiecki , Vijaya J. Gracias , Kathy A. Sarris , Douglas M. Kalvin , Melissa J. Michmerhuizen , Qi Shuai , Jyoti R. Patel , Margaretha H. M. Bakker , Nicole Teusch , Eric F. Johnson , Peter J. Kovar , Stevan W. Djuric , Andrew J. Long , Anil Vasudevan , Dawn M. George , Lu Wang , Biqin Li , Nigel S. Moore , Adrian D. Hobson , Keith W. Woods , Julie M. Miyashiro , Steven L. Swann, Jr. , Thomas D. Penning
IPC分类号： C07D413/04 , C07D471/04 , C07D487/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D513/04
CPC分类号： C07D413/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中A，R 1，R 2，R 3和m在说明书中定义。 本发明还涉及制备所述化合物的方法和含有所述化合物的组合物，其可用于抑制激酶例如糖原合成酶激酶3（GSK-3），Rho激酶（ROCK），Janus激酶（JAK），Cdc7，AKT ，PAK4，PLK，CK2，KDR，MK2，JNK1，极光，pim1和nek2。
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