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公开(公告)号：US09925307B2
公开(公告)日：2018-03-27
申请号：US14634559
申请日：2015-02-27
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A61K38/00 , A61P43/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/52 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/38 , A61L27/50 , A61L26/00 , A61K9/06
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US10286111B2
公开(公告)日：2019-05-14
申请号：US15398412
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A61K38/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/38 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/50 , A61L27/52 , A61L26/00 , A61K9/06 , A61K35/33 , C12N5/071
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US09555163B2
公开(公告)日：2017-01-31
申请号：US14634559
申请日：2015-02-27
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A61K38/00 , A61P43/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/52 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/38 , A61L27/50 , A61L26/00 , A61K9/06
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US08999916B2
公开(公告)日：2015-04-07
申请号：US13751295
申请日：2013-01-28
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A61K38/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L26/00
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
Abstract translation: 本发明涉及水凝胶，其包含能够自组装成三维大分子纳米纤维网络的多个两亲肽和/或拟肽，其夹带水并形成所述水凝胶，其中所述多个两亲肽的至少一部分和/ 或拟肽化学交联。 本发明还涉及制备这种水凝胶的方法和这种水凝胶的各种用途，例如， 作为用于药物和基因递送的细胞培养底物，作为伤口敷料，作为植入物，作为原位凝胶的药物或化妆品组合物，再生医学，组织工程和组织再生或电子装置中的注射剂。 它还涉及使用根据本发明的水凝胶的组织再生或组织置换的方法。
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公开(公告)号：US20170182219A1
公开(公告)日：2017-06-29
申请号：US15398412
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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Patent Agency Ranking
公开(公告)号：US09687591B2
公开(公告)日：2017-06-27
申请号：US14639035
申请日：2015-03-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A01N25/00 , A61K47/00 , A61L27/52 , A61L27/22 , A61L27/38 , A61L27/50 , A61L26/00 , C12N5/00 , A61L27/60
CPC classification number: A61L27/52 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/60 , A61L2430/06 , A61L2430/16 , C12N5/0068 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogel membranes comprising a hydrogel, said hydrogel comprising a plurality of tetramer amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of tetramer amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to stratisfied biostructures and devices comprising at least two hydrogel membranes of the invention, which can be used e.g. to rebuild human skin and for tissue engineering of organs and tissues. The present invention further relates to corneal implants and devices comprising a hydrogel membrane of the invention.
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公开(公告)号：US20150273114A1
公开(公告)日：2015-10-01
申请号：US14634559
申请日：2015-02-27
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
Abstract translation: 本发明涉及水凝胶，其包含能够自组装成三维大分子纳米纤维网络的多个两亲肽和/或拟肽，其夹带水并形成所述水凝胶，其中所述多个两亲肽的至少一部分和/ 或拟肽化学交联。 本发明还涉及制备这种水凝胶的方法和这种水凝胶的各种用途，例如， 作为用于药物和基因递送的细胞培养底物，作为伤口敷料，作为植入物，作为原位凝胶的药物或化妆品组合物，再生医学，组织工程和组织再生或电子装置中的注射剂。 它还涉及使用根据本发明的水凝胶的组织再生或组织置换的方法。
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公开(公告)号：US10293083B2
公开(公告)日：2019-05-21
申请号：US15398254
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A61K38/00 , A01N25/00 , A01N47/00 , C12N5/00 , C12N5/02 , A61L27/38 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/50 , A61L27/52 , A61L26/00 , A61K9/06 , A61K35/33 , C12N5/071
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US20170182218A1
公开(公告)日：2017-06-29
申请号：US15398288
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US20130267455A1
公开(公告)日：2013-10-10
申请号：US13751295
申请日：2013-01-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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