公开(公告)号：US20140156002A1

公开(公告)日：2014-06-05

申请号：US14174133

申请日：2014-02-06

Applicant: Allergan, Inc.

Inventor： Jordan Thompson ,  Alexei Goraltchouk ,  Kevin Ma

IPC: A61F2/12

CPC classification number: A61F2/12 ,  A61F2/0077 ,  A61F2240/001 ,  A61L27/34 ,  A61L27/56 ,  A61L2400/08 ,  A61L2400/18 ,  A61L2430/04 ,  B29C41/14 ,  B29C43/02 ,  B29C59/005 ,  B29C59/02 ,  B29C65/483 ,  B29C66/71 ,  B29C66/727 ,  B29L2031/7532 ,  B29K2083/00 ,  C08L83/04

Abstract: Methods for creating a foam-like texture on an implantable material are provided. More particularly, methods for creating foam-like texture on implantable silicone materials are provided.

Abstract translation: 提供了在可植入材料上形成泡沫样纹理的方法。 更具体地，提供了用于在可植入硅酮材料上产生泡沫状纹理的方法。

公开(公告)号：US20140154491A1

公开(公告)日：2014-06-05

申请号：US14174111

申请日：2014-02-06

Applicant: ALLERGAN, INC.

Inventor： Alexei Goraltchouk ,  Jordan Thompson ,  Miriam M. Abiad ,  Kevin Ma ,  Dennis Van Epps ,  Nicholas J. Manesis

IPC: C08J9/26

CPC classification number: C08J9/26 ,  C08J9/365 ,  C08J2201/046

Abstract: Described herein are foam-like materials having substantially the same physical structure of polyurethane foams but with properties that can be tailored for a particular application. Methods of forming these foam-like materials are also described.

Abstract translation: 本文描述的是具有基本相同的聚氨酯泡沫的物理结构的泡沫状材料，但具有可针对特定应用而定制的性质。 还描述了形成这些泡沫状材料的方法。

公开(公告)号：US08697763B2

公开(公告)日：2014-04-15

申请号：US13851877

申请日：2013-03-27

Applicant: Allergan, Inc.

Inventor： Alexei Goraltchouk ,  Jordan Thompson ,  Dennis Van Epps

IPC: A61L27/56

CPC classification number: B32B5/16 ,  A61L27/18 ,  A61L27/56 ,  A61L2400/18 ,  B32B5/18 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/046 ,  C08J2201/0502 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2383/04 ,  Y10T428/249921 ,  Y10T428/268 ,  C08L83/04

Abstract: Described herein are methods of making open celled foams including a matrix of interconnected spheres. The open celled foams are silicone based materials and can be used to coat implants, such as breast implants, and function to encourage tissue ingrowth and reduce capsular formation.

Abstract translation: 本文描述的是制备开孔泡沫的方法，包括相互连接的球体的基质。 开孔泡沫是硅基材料，可用于涂覆植入物，例如乳房植入物，以及促进组织向内生长并减少荚膜形成的功能。

公开(公告)号：US20130295379A1

公开(公告)日：2013-11-07

申请号：US13939141

申请日：2013-07-10

Applicant: Allergan, Inc.

Inventor： Alexei Goraltchouk ,  Jordan Thompson ,  Dennis Van Epps

IPC: B32B5/16 ,  B32B5/18

CPC classification number: B32B5/16 ,  A61L27/18 ,  A61L27/56 ,  A61L2400/18 ,  B32B5/18 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/046 ,  C08J2201/0502 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2383/04 ,  Y10T428/249921 ,  Y10T428/268 ,  C08L83/04

Abstract: Described herein are open celled foams including a matrix of interconnected spheres. Also described herein are methods of making open celled foams as well as making composite members with open celled foam coatings covering at least a portion of the composite member. The open celled foams described herein are silicone based materials and can be used to coat implants such as breast implants and function to encourage tissue ingrowth and reduce capsular formation.

Abstract translation: 本文描述的是开孔细胞泡沫，包括相互连接的球体的基质。 本文还描述了制备开孔泡沫的方法，以及制备覆盖至少一部分复合构件的开孔泡沫涂层的复合构件。 本文所述的开孔泡沫体是基于硅酮的材料，并且可以用于涂覆诸如乳房植入物的植入物和促进组织向内生长并减少荚膜形成的功能。

公开(公告)号：US10391199B2

公开(公告)日：2019-08-27

申请号：US14842569

申请日：2015-09-01

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Alexei Goraltchouk ,  Dimitri Stroumpoulis

IPC: A61F2/12 ,  A61L27/18 ,  B29C41/14 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58

Abstract: The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

公开(公告)号：US20160022866A1

公开(公告)日：2016-01-28

申请号：US14842569

申请日：2015-09-01

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Alexei Goraltchouk ,  Dimitri Stroumpoulis

IPC: A61L27/18

CPC classification number: A61L27/18 ,  A61F2/12 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  B05D2400/00 ,  B05D2518/00 ,  B29C41/14 ,  C08L83/04

Abstract: The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

公开(公告)号：US20150132469A1

公开(公告)日：2015-05-14

申请号：US14602907

申请日：2015-01-22

Applicant: Allergan, Inc.

Inventor： Alexei Goraltchouk ,  Dennis E. Van Epps ,  Thomas E. Powell

IPC: B05D3/10 ,  A61L27/56 ,  A61F2/12

CPC classification number: B05D3/107 ,  A61F2/12 ,  A61L27/30 ,  A61L27/56 ,  A61L2400/18

Abstract: Implantable prosthesis, components of prosthesis, and methods of making same are provided. The methods generally include the steps of providing an implant shell, applying a curable fluid composition to the shell to form a coating thereon and applying a particulate component to the composition. The composition is a mixture, for example, an emulsion, containing a silicone-based elastomer dispersion and droplets of a suspended leachable agent. After the elastomer is stabilized and cured, the particulate component and leachable agent are removed, resulting in an implantable member having a porous, open-cell surface texture designed to be effective in reducing incidence of capsular formation or contraction.

Abstract translation: 提供可植入假体，假体的组成部分及其制造方法。 所述方法通常包括提供植入物外壳，将可固化流体组合物施加到外壳上以在其上形成涂层的步骤，并将颗粒组分施用于组合物。 组合物是混合物，例如含有硅氧烷基弹性体分散体和悬浮的可浸出试剂的液滴的乳液。 在弹性体稳定和固化之后，除去颗粒组分和可浸出的试剂，得到可植入的构件，其具有设计成有效减少荚膜形成或收缩的发生率的多孔，开放细胞表面织构。

公开(公告)号：US20150028510A1

公开(公告)日：2015-01-29

申请号：US14512839

申请日：2014-10-13

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Alexei Goraltchouk ,  Dimitrios Stroumpoulis

IPC: B29C67/20 ,  A61K47/34 ,  A61L26/00

CPC classification number: B29C67/202 ,  A61K47/34 ,  A61L26/0019 ,  B29K2067/04 ,  B29K2083/005 ,  B29K2105/0085 ,  B29L2031/753 ,  C08J9/26 ,  C08J2201/0462 ,  C08J2383/04 ,  Y10T428/249921

Abstract: The present specification discloses porous materials, methods of forming such porous materials, materials and devices comprising such porous materials, and methods of making such materials and devices.

Abstract translation: 本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的材料和装置以及制造这种材料和装置的方法。

公开(公告)号：US20160120821A1

公开(公告)日：2016-05-05

申请号：US14987373

申请日：2016-01-04

Applicant: Allergan, Inc.

Inventor： Jordan Thompson ,  Alexei Goraltchouk

IPC: A61K9/70 ,  B29C35/02 ,  B29C41/50 ,  A61K31/355 ,  A61K9/00

CPC classification number: A61K9/7007 ,  A61K9/0014 ,  A61K31/355 ,  A61L15/26 ,  A61L15/44 ,  A61L15/58 ,  B29C35/02 ,  B29C39/42 ,  B29C41/50 ,  B29K2083/00 ,  B29L2031/753 ,  C08L83/04

Abstract: Provided are methods of making devices that can be applied to the skin to promote healing of wounds and the reduction or prevention of scarring. The devices include compositions of various silicone compounds loaded with active pharmaceutical agents.

Abstract translation: 提供了制造可应用于皮肤以促进伤口愈合并减少或预防瘢痕形成的方法。 这些装置包括装有活性药剂的各种硅氧烷化合物的组合物。

公开(公告)号：US09138309B2

公开(公告)日：2015-09-22

申请号：US13625159

申请日：2012-09-24

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Alexei Goraltchouk ,  Dimitrios Stroumpoulis

IPC: A61F2/12 ,  B29C41/14 ,  A61L27/56 ,  A61L27/18 ,  A61L27/50 ,  A61L27/58

CPC classification number: A61L27/18 ,  A61F2/12 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  B05D2400/00 ,  B05D2518/00 ,  B29C41/14 ,  C08L83/04

Abstract: The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Abstract translation: 本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法。