公开(公告)号：US20240366490A1

公开(公告)日：2024-11-07

申请号：US18543854

申请日：2023-12-18

Applicant: Allergan, Inc.

Inventor： Elizabeta Pavlovic ,  Monica A. Serban ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61K8/64 ,  A61K8/73 ,  A61L27/20 ,  A61L27/22 ,  A61L27/36 ,  A61L27/52 ,  A61Q19/08 ,  C08B37/08 ,  C08H1/00 ,  C08J3/075 ,  C08J3/24 ,  C08L5/08 ,  C08L89/00

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

公开(公告)号：US20220023186A1

公开(公告)日：2022-01-27

申请号：US17396597

申请日：2021-08-06

Applicant: Allergan, Inc.

Inventor： Gabriel N. Njikang ,  Xiaojie Yu ,  Futian Liu ,  Nicholas J. Manesis

IPC: A61K8/73 ,  A61L27/20 ,  C08B37/08 ,  A61L27/52 ,  A61K8/04 ,  A61Q19/08 ,  A61Q19/00

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

公开(公告)号：US20200038550A1

公开(公告)日：2020-02-06

申请号：US16517310

申请日：2019-07-19

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Alexei Goraltchouk ,  Dimitri Stroumpoulis

IPC: A61L27/18 ,  A61L27/58 ,  A61L27/56 ,  A61L27/50 ,  A61F2/12 ,  B29C41/14

Abstract: The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices that include such porous materials, and methods of making such biocompatible implantable devices.

公开(公告)号：US10434214B2

公开(公告)日：2019-10-08

申请号：US15727916

申请日：2017-10-09

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61K8/04 ,  A61K8/73 ,  A61L27/24 ,  A61L27/26 ,  A61L27/36 ,  A61L27/52 ,  A61Q19/08

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US09795711B2

公开(公告)日：2017-10-24

申请号：US15609967

申请日：2017-05-31

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61K8/65 ,  A61Q19/08 ,  A61L27/52 ,  A61L27/36 ,  A61L27/26 ,  A61K8/73 ,  A61K8/04

CPC classification number: A61L27/24 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/26 ,  A61L27/3695 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L5/08 ,  C08L89/06

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US20140315828A1

公开(公告)日：2014-10-23

申请号：US13868010

申请日：2013-04-22

Applicant: ALLERGAN, INC.

Inventor： Elizabeta Pavlovic ,  Monica A. Serban ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61K8/64 ,  A61Q19/08

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

Abstract translation: 可用作真皮填料的组合物和使用这种组合物治疗各种皮肤和软组织病症的方法。 真皮填料可以包括使用例如两个交联剂连接到透明质酸的丝，并且可以用于治疗面部缺陷，面部缺陷，面部增大，乳房缺陷，隆胸或乳房重建。

公开(公告)号：US20140121771A1

公开(公告)日：2014-05-01

申请号：US14148547

申请日：2014-01-06

Applicant: Allergan, Inc.

Inventor： Kaustubh S. Chitre ,  Nicholas J. Manesis ,  Nikhil Trilokekar ,  Dustin Leslie ,  David Schuessler

IPC: A61F2/12

CPC classification number: A61F2/12 ,  A61B90/02 ,  A61F2210/0076 ,  A61F2250/0003 ,  A61F2250/0004

Abstract: An inflatable tissue expander or more permanent prosthesis, suitable for implantation in a breast, is provided. The tissue expander includes a puncturable, self-sealing anterior portion forming a fillable cavity, and posterior portion that is puncture resistant. The anterior portion includes a silicone-based elastomer material having a mesh embedded therein. The posterior portion includes a first composite guard and a second composite guard, each composite guard including an arrangement of puncture resistant members and a flexible substrate having a first side on which the puncture resistant members are disposed in a spaced apart fashion.

Abstract translation: 提供了一种适合植入乳房的可充气组织扩张器或更多的永久假体。 组织扩张器包括形成可填充空腔的可穿刺的，自密封的前部，以及防刺穿的后部。 前部包括具有嵌入其中的网的硅酮基弹性体材料。 后部包括第一复合防护件和第二复合防护件，每个复合防护罩包括防穿刺构件的布置和具有第一侧面的柔性基底，防穿孔构件以隔开的方式设置在该第一侧上。

公开(公告)号：US20140011980A1

公开(公告)日：2014-01-09

申请号：US13934976

申请日：2013-07-03

Applicant: Allergan, Inc.

Inventor： Kaustubh S. Chitre ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61L2/08

CPC classification number: A61L2/08 ,  A61L2/084 ,  A61L2/085 ,  A61L2/10 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/52

Abstract: Method for sterilizing a hydrogel composition include subjecting the composition to pulsed light comprising broadband spectrum radiation, the pulsed light being at a dose effective to sterilize the composition without causing significant change in rheology of the composition.

Abstract translation: 用于对水凝胶组合物进行灭菌的方法包括使组合物经受包含宽带光谱辐射的脉冲光，脉冲光以有效消毒组合物的剂量而不引起组合物流变学的显着变化。

公开(公告)号：US20130023987A1

公开(公告)日：2013-01-24

申请号：US13625159

申请日：2012-09-24

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Alexei Goraltchouk ,  Dimitrios Stroumpoulis

IPC: B05D5/00 ,  A61F2/12 ,  B05D3/00

CPC classification number: A61L27/18 ,  A61F2/12 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  B05D2400/00 ,  B05D2518/00 ,  B29C41/14 ,  C08L83/04

Abstract: The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Abstract translation: 本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法。

公开(公告)号：US20250114187A1

公开(公告)日：2025-04-10

申请号：US18800556

申请日：2024-08-12

Applicant: Allergan, Inc.

Inventor： Kaustubh S. Chitre ,  Nicholas J. Manesis ,  Nikhil S. Trilokekar ,  Dustin Leslie ,  David John Schuessler

IPC: A61F2/12

Abstract: A prosthesis can include a shell and a needle guard coupled to a posterior portion of the shell. The shell can include a laminate having a base layer, a top layer, and a soft silicone gel intermediate layer disposed between the base layer and the top layer and of sufficient thickness for self-sealing of a needle hole therethrough. The needle guard can include a plurality of offset layers of offset, puncture-resistance structures that, in an expanded state, (i) collectively form a concave shape and (ii) provide a concave exterior surface along the posterior portion of the prosthesis for approximating a human anatomical feature. The needle guard can have a shape memory characteristic for urging the prosthesis toward the expanded state.