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公开(公告)号：US20210370319A1
公开(公告)日：2021-12-02
申请号：US17400419
申请日：2021-08-12
Inventor： Mark Hayes , Claire Crowther , Paul Jones
Abstract: The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.
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公开(公告)号：US20240149275A1
公开(公告)日：2024-05-09
申请号：US18479220
申请日：2023-10-02
Inventor： Mark Hayes , Claire Crowther , Paul Jones
CPC classification number: B03C5/026 , B01L3/502753 , B03C5/005 , G01N15/1023 , G01N15/1484 , G01N27/447 , G01N27/44791 , B01L2400/0424 , B01L2400/086 , G01N2015/1006
Abstract: The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.
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公开(公告)号：US10022728B2
公开(公告)日：2018-07-17
申请号：US14764875
申请日：2014-02-03
Inventor： Mark Hayes , Paul Jones , Stacy Kenyon , Michael Keebaugh , Thomas Taylor , Prasun Mahanti , Sarah Staton , Noah Weiss
IPC: G01N27/447 , G01N27/453 , B03C7/02 , B03C5/00 , G01N30/00 , B03C5/02 , B01L3/00 , G06F17/50
Abstract: The present invention provides devices and methods to separate and concentrate target species. In some embodiments, a punctuated continuous microchannel or parallel processing (array-based) separations are provided, the microchannel having a plurality of sequential, constrictive insulating features to form a plurality of reservoirs including a first, second and third reservoir, and a plurality of constricted passageways including a first constricted passageway that connects the first reservoir to the second reservoir and a second constricted passageway that connects the second reservoir to the third reservoir. A voltage is applied to the microchannel to create different electrical fields and/or different dielectrophoresis (DEP) gradients at each of the plurality of constricted passageways in order to separate species that have differing ratios of electrokinetic mobility to dielectrophoretic mobility.
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公开(公告)号：US09476085B2
公开(公告)日：2016-10-25
申请号：US14874021
申请日：2015-10-02
Inventor： Thomas Taylor , Mark Hayes , LaKeta Kemp , Paul Jones
CPC classification number: C12Q1/10 , B01D57/02 , B03C5/005 , B03C5/026 , B03C2201/26 , C12M47/04 , C12Q1/24 , G01N27/44773 , G01N27/44791 , H04N7/18
Abstract: The present invention provides for separation of bacterial species and serotypes using electrophoretic methods.
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公开(公告)号：US11806729B2
公开(公告)日：2023-11-07
申请号：US17400419
申请日：2021-08-12
Inventor： Mark Hayes , Claire Crowther , Paul Jones
CPC classification number: B03C5/026 , B01L3/502753 , B03C5/005 , G01N15/1056 , G01N15/1484 , G01N27/447 , G01N27/44791 , B01L2400/0424 , B01L2400/086 , G01N2015/1006
Abstract: The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.
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Patent Agency Ranking
公开(公告)号：US20220152629A1
公开(公告)日：2022-05-19
申请号：US17531284
申请日：2021-11-19
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES
Inventor： Mark Hayes , Jason Dwyer , Alexis Ramirez , Brian Sheetz
IPC: B03C5/00
Abstract: The present disclosure provides a system including an insulator-based dielectrophoresis device. The insulator-based dielectrophoresis device includes a fluid flow channel having at least one fluid inlet and at least one fluid outlet. The fluid flow channel includes at least one insulating flow structure extending from a wall to define a constriction in the fluid flow channel. The system includes a detection chamber placed in fluid communication with the fluid flow channel by an opening in the wall of the fluid flow channel, where the opening is configured downstream of the at least one insulation flow structure. The detection chamber includes an electrochemical sensor configured to constrict the flow of fluid entering the detection chamber through a pore, where the pore is sized to produce a detectable signal upon passage of an analyte through the pore. The system may process the detectable signal to output a metric indicative of the identity or physiochemical property of the analyte.
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公开(公告)号：US11090660B2
公开(公告)日：2021-08-17
申请号：US16324324
申请日：2017-08-10
Inventor： Mark Hayes , Claire Crowther , Paul Jones
Abstract: The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.
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公开(公告)号：US09938330B2
公开(公告)日：2018-04-10
申请号：US14388209
申请日：2013-03-12
Inventor： Michael Sierks , Mark Hayes
IPC: G01N27/447 , C07K14/47 , B03C5/00 , B03C5/02 , B01L3/00
CPC classification number: C07K14/4711 , B01L3/5027 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N27/447
Abstract: The present invention provides devices and methods to separate and concentrate target protein species at a microliter scale and to generate reagents to those variants with exquisite selectivity for specific protein isoforms using only picograms of target material.
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公开(公告)号：US12208400B2
公开(公告)日：2025-01-28
申请号：US18563438
申请日：2022-05-25
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Mark Hayes , Mikhail Skliar , Marc Porter , Brennan Copp , Samuel Hayes , Alexis Ramirez
Abstract: The present disclosure provides systems and methods for separating one or more analytes within a fluid mixture, and characterizing and/or detecting properties associated with the one or more analytes. In some embodiments, the systems provided herein contain a dielectrophoresis device, such as a gradient insulator-based dielectrophoresis device (g-iDEP). The present disclosure provides systems and methods for separating and characterizing analytes using particle or nanoparticle tracking analysis (NTA). NTA offers various advantages because, particle size and concentration can be calculated in real time, allowing label-free and simultaneous characterization and separation of samples with mixed and unknown analytes.
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公开(公告)号：US20190168237A1
公开(公告)日：2019-06-06
申请号：US16324324
申请日：2017-08-10
Inventor： Mark Hayes , Claire Crowther , Paul Jones
IPC: B03C5/02 , B03C5/00 , G01N27/447 , G01N15/10
Abstract: The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.
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