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1.发明授权公开(公告)号：US08187864B2
公开(公告)日：2012-05-29
申请号：US12285326
申请日：2008-10-01
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides an exchangeable, reagent pre-loaded sheets which can be temporarily applied to an electrode array on a digital microfluidic device (DMF). The substrate facilitates virtually un-limited re-use of the DMF devices avoiding cross-contamination on the electrode array itself, as well as enabling rapid exchange of pre-loaded reagents while bridging the world-to-chip interface of DMF devices. The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译： 本发明提供了可以临时施加到数字微流体装置（DMF）上的电极阵列的可更换的试剂预加载片。 基板有助于几何不受限制地重复使用DMF装置，以避免电极阵列本身的交叉污染，并且能够在桥接DMF装置的世界到芯片的界面的同时快速交换预加载的试剂。 本发明允许将DMF转化成用于芯片实验室的通用平台。
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2.发明申请公开(公告)号：US20100081578A1
公开(公告)日：2010-04-01
申请号：US12285326
申请日：2008-10-01
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides an exchangeable, reagent pre-loaded sheets which can be temporarily applied to an electrode array on a digital microfluidic device (DMF). The substrate facilitates virtually un-limited re-use of the DMF devices avoiding cross-contamination on the electrode array itself, as well as enabling rapid exchange of pre-loaded reagents while bridging the world-to-chip interface of DMF devices. The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译： 本发明提供了可以临时施加到数字微流体装置（DMF）上的电极阵列的可更换的试剂预加载片。 基板有助于几何不受限制地重复使用DMF装置，以避免电极阵列本身的交叉污染，并且能够在桥接DMF装置的世界到芯片的界面的同时快速交换预加载的试剂。 本发明允许将DMF转化成用于芯片实验室的通用平台。
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3.发明授权Exchangeable carriers pre-loaded with reagent depots for digital microfluidics 有权可交换运营商预装了数字微流体的试剂库公开(公告)号：US08993348B2
公开(公告)日：2015-03-31
申请号：US13122311
申请日：2009-09-30
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides exchangeable, reagent pre-loaded carriers (10), preferably in the form of plastic sheets, which can be temporarily applied to an electrode array (16) on a digital microfluidic (DMF) device (14). The carrier (10) facilitates virtually un-limited re-use of the DMF devices (14) avoiding cross-contamination on the electrode array (16) itself, as well as enabling rapid exchange of pre-loaded reagents (12) while bridging the world-to-chip interface of DMF devices (14). The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译： 本发明提供可更换的试剂预加载载体（10），优选为塑料片的形式，其可暂时施加到数字微流体（DMF）装置（14）上的电极阵列（16）。 载体（10）有助于几乎不受限制地使用DMF装置（14），以避免电极阵列（16）本身上的交叉污染，并且能够快速交换预加载的试剂（12），同时桥接 DMF设备的世界到芯片接口（14）。 本发明允许将DMF转化成用于芯片实验室的通用平台。
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4.发明申请公开(公告)号：US20110240471A1
公开(公告)日：2011-10-06
申请号：US13122311
申请日：2009-09-30
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides exchangeable, reagent pre-loaded carriers (10), preferably in the form of plastic sheets, which can be temporarily applied to an electrode array (16) on a digital microfluidic (DMF) device (14). The carrier (10) facilitates virtually un-limited re-use of the DMF devices (14) avoiding cross-contamination on the electrode array (16) itself, as well as enabling rapid exchange of pre-loaded reagents (12) while bridging the world-to-chip interface of DMF devices (14). The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译： 本发明提供可更换的试剂预加载载体（10），优选为塑料片的形式，其可暂时施加到数字微流体（DMF）装置（14）上的电极阵列（16）。 载体（10）有助于几乎不受限制地使用DMF装置（14），以避免电极阵列（16）本身上的交叉污染，并且能够快速交换预加载的试剂（12），同时桥接 DMF设备的世界到芯片接口（14）。 本发明允许将DMF转化成用于芯片实验室的通用平台。
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5.发明授权公开(公告)号：US09039973B2
公开(公告)日：2015-05-26
申请号：US13123463
申请日：2009-10-13
IPC分类号： B01L99/00 , G01N1/28 , G01N27/62 , B05B5/025 , B23P19/00 , G01N27/447 , G01N35/10 , B01L3/00 , H01J49/04 , H01J49/16
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502753 , B01L3/502792 , B01L2200/027 , B01L2300/0816 , B01L2300/089 , B01L2400/0415 , B01L2400/0421 , G01N35/10 , G01N35/1095 , G01N2035/1041 , H01J49/04 , H01J49/0445 , H01J49/165 , H01J49/167 , Y10T29/49826 , Y10T436/25375
摘要： The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device.
摘要翻译： 本发明提供了一种集成结构形式的混合数字和通道微流体装置，其中液滴可以通过数字微流体阵列传输并转移到微流体通道。 在本发明的一个方面，混合器件包括具有能够将液滴输送到转移位置的数字微流体阵列的第一衬底和具有微流体通道的第二衬底。 第一和第二基底被固定以形成混合装置，其中微流体通道中的开口邻近转移位置定位，使得运送到转移位置的液滴接触通道开口并且可进入通道。 本发明还提供使用混合数字和通道微流体装置进行分离的方法以及组装混合数字微流体装置的方法。
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6.发明申请公开(公告)号：US20120083046A1
公开(公告)日：2012-04-05
申请号：US13123463
申请日：2009-10-13
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502753 , B01L3/502792 , B01L2200/027 , B01L2300/0816 , B01L2300/089 , B01L2400/0415 , B01L2400/0421 , G01N35/10 , G01N35/1095 , G01N2035/1041 , H01J49/04 , H01J49/0445 , H01J49/165 , H01J49/167 , Y10T29/49826 , Y10T436/25375
摘要： The present invention provides a hybrid digital and channel microfluidic device in the form of an integrated structure in which a droplet may be transported by a digital microfluidic array and transferred to a microfluidic channel. In one aspect of the invention, a hybrid device comprises a first substrate having a digital microfluidic array capable of transporting a droplet to a transfer location, and a second substrate having a microfluidic channel. The first and second substrates are affixed to form a hybrid device in which an opening in the microfluidic channel is positioned adjacent to the transfer location, so that a droplet transported to the transfer location contacts the channel opening and may enter the channel. The invention also provides methods of performing separations using a hybrid digital and channel microfluidic device and methods of assembling a hybrid digital microfluidic device.
摘要翻译： 本发明提供了一种集成结构形式的混合数字和通道微流体装置，其中液滴可以通过数字微流体阵列传输并转移到微流体通道。 在本发明的一个方面，混合器件包括具有能够将液滴输送到转移位置的数字微流体阵列的第一衬底和具有微流体通道的第二衬底。 第一和第二基底被固定以形成混合装置，其中微流体通道中的开口邻近转移位置定位，使得运送到转移位置的液滴接触通道开口并且可进入通道。 本发明还提供使用混合数字和通道微流体装置进行分离的方法以及组装混合数字微流体装置的方法。
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