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15 条记录 (耗时 0.029 秒)

    Apparatus and method for handling membranes
    1.
    发明授权
    Apparatus and method for handling membranes 失效
    用于处理膜的装置和方法

    公开(公告)号：US07422651B2

    公开(公告)日：2008-09-09

    申请号：US11011558

    申请日：2004-12-14

    申请人： Aaron Raphel ,  Enoch Kim ,  Emanuele Ostuni ,  Gregory Kirk ,  Olivier Schueller

    发明人： Aaron Raphel ,  Enoch Kim ,  Emanuele Ostuni ,  Gregory Kirk ,  Olivier Schueller

    IPC分类号： C09J5/10 ,  B32B37/00 ,  B32B37/12 ,  B32B37/14 ,  C03C25/10 ,  B32B37/10 ,  B32B37/16 ,  C03C25/18

    CPC分类号： B29C41/02 ,  B29C33/424 ,  B29L2031/755 ,  Y10T428/24802 ,  Y10T428/31504

    摘要： A method for applying a pattern to a target surface includes the steps of applying a coating of membrane material over a selected portion of a substrate. The substrate imparts a pattern to the membrane material corresponding to a pattern to be applied to the target surface. A support member is positioned in contact with an outer portion of the membrane material. The support member has a higher rigidity than the membrane material. The method may also combine the steps of curing the membrane material to bond the support member to the membrane. When bonded to the membrane, the support member maintains at least a portion of the membrane in a substantially taut condition to prevent a portion of the membrane from folding onto itself. The membrane is then employed to impart the pattern to the target surface.

    摘要翻译： 将图案应用于目标表面的方法包括以下步骤：在衬底的选定部分上涂覆膜材料涂层。 基板将膜施加到与施加到目标表面的图案相对应的图案。 支撑构件定位成与膜材料的外部部分接触。 支撑构件具有比膜材料更高的刚性。 该方法还可以组合固化膜材料以将支撑构件结合到膜的步骤。 当粘合到膜时，支撑构件将膜的至少一部分保持在基本拉紧的状态，以防止膜的一部分折叠到其自身上。 然后使用膜将图案赋予目标表面。

    Apparatus and method for handling membranes
    2.
    发明申请
    Apparatus and method for handling membranes 失效
    用于处理膜的装置和方法

    公开(公告)号：US20050095362A1

    公开(公告)日：2005-05-05

    申请号：US11011558

    申请日：2004-12-14

    申请人： Aaron Raphel ,  Enoch Kim ,  Emanuele Ostuni ,  Gregory Kirk ,  Olivier Schueller

    发明人： Aaron Raphel ,  Enoch Kim ,  Emanuele Ostuni ,  Gregory Kirk ,  Olivier Schueller

    IPC分类号： B29C33/42 ,  B29C41/02 ,  B05D5/00

    CPC分类号： B29C41/02 ,  B29C33/424 ,  B29L2031/755 ,  Y10T428/24802 ,  Y10T428/31504

    摘要： A method for applying a pattern to a target surface includes the steps of applying a coating of membrane material over a selected portion of a substrate. The substrate imparts a pattern to the membrane material corresponding to a pattern to be applied to the target surface. A support member is positioned in contact with an outer portion of the membrane material. The support member has a higher rigidity than the membrane material. The method may also combine the steps of curing the membrane material to bond the support member to the membrane. When bonded to the membrane, the support member maintains at least a portion of the membrane in a substantially taut condition to prevent a portion of the membrane from folding onto itself. The membrane is then employed to impart the pattern to the target surface.

    摘要翻译： 将图案应用于目标表面的方法包括以下步骤：在衬底的选定部分上涂覆膜材料涂层。 基板将膜施加到与施加到目标表面的图案相对应的图案。 支撑构件定位成与膜材料的外部部分接触。 支撑构件具有比膜材料更高的刚性。 该方法还可以组合固化膜材料以将支撑构件结合到膜的步骤。 当粘合到膜时，支撑构件将膜的至少一部分保持在基本拉紧的状态，以防止膜的一部分折叠到其自身上。 然后使用膜将图案赋予目标表面。

    Apparatus and method for handling membranes
    3.
    发明授权
    Apparatus and method for handling membranes 失效
    用于处理膜的装置和方法

    公开(公告)号：US06833040B2

    公开(公告)日：2004-12-21

    申请号：US10033863

    申请日：2001-12-19

    申请人： Aaron Raphel ,  Enoch Kim ,  Emanuele Ostuni ,  Gregory Kirk ,  Olivier Schueller

    发明人： Aaron Raphel ,  Enoch Kim ,  Emanuele Ostuni ,  Gregory Kirk ,  Olivier Schueller

    IPC分类号： B44C100

    CPC分类号： B29C41/02 ,  B29C33/424 ,  B29L2031/755 ,  Y10T428/24802 ,  Y10T428/31504

    摘要： A method for applying a pattern to a target surface includes the steps of applying a coating of membrane material over a selected portion of a substrate. The substrate imparts a pattern to the membrane material corresponding to a pattern to be applied to the target surface. A support member is positioned in contact with an outer portion of the membrane material. The support member has a higher rigidity than the membrane material. The method may also combine the steps of curing the membrane material to bond the support member to the membrane. When bonded to the membrane, the support member maintains at least a portion of the membrane in a substantially taut condition to prevent a portion of the membrane from folding onto itself. The membrane is then employed to impart the pattern to the target surface.

    摘要翻译： 将图案应用于目标表面的方法包括以下步骤：在衬底的选定部分上涂覆膜材料涂层。 基板将膜施加到与施加到目标表面的图案相对应的图案。 支撑构件定位成与膜材料的外部部分接触。 支撑构件具有比膜材料更高的刚性。 该方法还可以组合固化膜材料以将支撑构件结合到膜的步骤。 当粘合到膜时，支撑构件将膜的至少一部分保持在基本拉紧的状态，以防止膜的一部分折叠到其自身上。 然后使用膜将图案赋予目标表面。

    Cell motility and chemotaxis test device and methods of using same
    8.
    发明授权
    Cell motility and chemotaxis test device and methods of using same 失效

    公开(公告)号：US06982171B2

    公开(公告)日：2006-01-03

    申请号：US10385657

    申请日：2003-03-12

    申请人： Enoch Kim ,  Gregory Kirk ,  Matthew Brown ,  Emanuele Ostuni

    发明人： Enoch Kim ,  Gregory Kirk ,  Matthew Brown ,  Emanuele Ostuni

    IPC分类号： C12N5/08

    CPC分类号： B01L3/5025 ,  B01L2300/0829 ,  B01L2400/086

    摘要： The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member by being placed in substantially fluid-tight conformal contact with the support member. The support member and the top member are configured such that they together define a discrete chamber adapted to allow a monitoring of chemotaxis or chemoinvasion therein. The discrete chamber includes a first well region including at least one first well, the at least one first well configured to received a test agent therein; a second well region including at least one second well, the at least one second well configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region with one another. The second well region is preferably horizontally offset with respect to the first well region in a test orientation of the device.

    Device for magnetic immobilization of cells
    9.
    发明授权
    Device for magnetic immobilization of cells 失效
    细胞磁固定装置

    公开(公告)号：US07285412B2

    公开(公告)日：2007-10-23

    申请号：US10084063

    申请日：2002-02-28

    申请人： Rocco Casagrande ,  Evelyn Wang ,  Gregory Kirk ,  Michael Nussbaum ,  Enoch Kim ,  Aaron Raphel

    发明人： Rocco Casagrande ,  Evelyn Wang ,  Gregory Kirk ,  Michael Nussbaum ,  Enoch Kim ,  Aaron Raphel

    IPC分类号： C12M1/12 ,  C12M1/34 ,  C12N11/02 ,  C12N11/08

    CPC分类号： G01N33/54326 ,  B01J2219/00317 ,  B01J2219/00655 ,  B01J2219/00659 ,  B01J2219/00743 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2400/043 ,  C12M33/00 ,  C40B60/14 ,  G01N35/0098

    摘要： The present invention relates to an apparatus and methods that immobilize one or more cells associated with magnetic material on a substrate on which are located one or more magnetic receptacle(s). Alternatively, in another aspect the present invention, the device arrays cells associated with magnetic material on a substrate having a pattern of magnetic receptacles disposed thereon. The size of the magnetic receptacle(s) determines the number of target cells that it is capable of immobilizing. The size of the magnetic receptacle is defined by the strength of a localized magnetic field gradient. The localized magnetic field gradient may be derived from 1) permanent magnets embedded in the substrate or alternatively, the localized magnetic field gradient may be derived from an 2) external magnet whose strength is focused by objects of highly-permeable-magnetic material which create localized magnetic field gradients. The invention apparatus comprises a removable cell delivery device and a substrate, which has one or more magnetic receptacles disposed thereon.

    摘要翻译： 本发明涉及一种将与磁性材料相关联的一个或多个单元固定在位于一个或多个磁性插座上的基板上的装置和方法。 或者，在本发明的另一方面，与衬底上的磁性材料相关联的器件阵列单元具有设置在其上的磁性容器的图案。 磁性容器的尺寸决定了能够固定的靶细胞的数量。 磁性容器的尺寸由局部磁场梯度的强度限定。 局部磁场梯度可以从1）嵌入在基板中的永久磁体衍生出来，或者，局部磁场梯度可以从2）外部磁体导出，该外部磁体的强度由产生局部磁性的高透磁性材料的物体聚焦 现场梯度。 本发明的装置包括一个可拆卸的电池输送装置和一个其上设置有一个或多个磁性插座的基板。