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    Device and methods for mixing fluids
    3.
    发明申请
    Device and methods for mixing fluids 有权
    混合流体的装置和方法

    公开(公告)号：US20020071339A1

    公开(公告)日：2002-06-13

    申请号：US10062431

    申请日：2002-01-30

    Applicant: AFFYMETRIX, INC.

    Inventor： James L. Winkler ,  Mark Chee ,  David Lockhart

    IPC: B01F015/06 ,  B01F011/00

    CPC classification number: B01J19/28 ,  B01F9/0021 ,  B01J2219/00488 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00659 ,  B01J2219/00722 ,  C40B40/06 ,  C40B60/14 ,  Y10S435/809

    Abstract: The invention provides exemplary devices, systems and methods for mixing of fluids, such as biological fluids. One exemplary device comprises is particularly adapted for holding at least one cartridge having a chamber containing a biological fluid, with the chamber having a generally planar face. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body such that the face of the chamber is generally perpendicular to the rotational axis.

    Abstract translation: 本发明提供了用于混合流体例如生物流体的示例性装置，系统和方法。 一个示例性装置包括特别适用于保持具有包含生物流体的腔室的至少一个筒，该腔室具有大致平坦的面。 该装置包括具有旋转轴线的可转动体。 可旋转主体包括至少一个安装元件，该安装元件适于安装可旋转主体，使得腔室的表面大致垂直于旋转轴线。

    Iterative resequencing
    5.
    发明申请
    Iterative resequencing 审中-公开
    迭代重排序

    公开(公告)号：US20040248176A1

    公开(公告)日：2004-12-09

    申请号：US10829015

    申请日：2004-04-20

    Applicant: Affymetrix, INC.

    Inventor： Mark Chee

    IPC: C12Q001/68

    CPC classification number: C12Q1/6874

    Abstract: The invention provides iterative methods of analyzing a target nucleic acid that represents a variant of a reference nucleic acid. An array of probes is designed to be complementary to an estimated sequence of a target nucleic acid. The array of probes is then hybridized to the target nucleic acid. The target sequence is reestimated from hybridization pattern of the array to the target nucleic acid. A further array of probes is then designed to be complementary to the reestimated sequence, and this array is used to obtain a further reestimate of the sequence of the target nucleic acid. By performing iterative cycles of array design and target sequence estimation, the estimated sequence of the target converges with the true sequence.

    Abstract translation: 本发明提供了分析代表参考核酸变体的靶核酸的迭代方法。 探针阵列设计成与靶核酸的估计序列互补。 然后将探针阵列与目标核酸杂交。 靶序列从阵列的杂交模式重新估计为靶核酸。 然后将另外的探针阵列设计为与重新估计的序列互补，并且该阵列用于获得靶核酸序列的进一步重新估计。 通过执行阵列设计和靶序列估计的迭代循环，目标的估计序列与真实序列收敛。

    Expression monitoring by hybridization to high density oligonucleotide arrays
    6.
    发明申请
    Expression monitoring by hybridization to high density oligonucleotide arrays 失效
    通过与高密度寡核苷酸阵列杂交进行表达监测

    公开(公告)号：US20030215841A1

    公开(公告)日：2003-11-20

    申请号：US10353792

    申请日：2003-01-28

    Applicant: Affymetrix, Inc.

    Inventor： David J. Lockhart ,  Eugene L. Brown ,  Gordon Wong ,  Mark Chee ,  Thomas R. Gingeras

    IPC: C12Q001/68

    CPC classification number: C12Q1/6809 ,  C12Q1/6837 ,  G01N15/1475 ,  C12Q2565/507

    Abstract: This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.

    Abstract translation: 本发明提供监测多种基因的表达水平的方法。 所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。 在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中 包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且所述寡核苷酸探针与 衍生自RNA转录物的RNA转录物或核酸; 并定量阵列中的杂交核酸。

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