公开(公告)号：US10717798B2

公开(公告)日：2020-07-21

申请号：US15779513

申请日：2016-11-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jackie Y. Ying ,  Nandanan Erathodiyil ,  Hong Wu ,  Hsi-Min Chan

IPC: C08K5/09 ,  C08F220/18 ,  A61L27/52 ,  A61L27/34 ,  C08L33/08 ,  C08F220/54 ,  C09D5/16 ,  C08F220/60 ,  C08K3/014 ,  C09D7/40 ,  C08F220/58 ,  C08K13/02 ,  C08K5/00 ,  C08L33/24

Abstract: A polymeric composition comprising (i) a plurality of monomers selected from (a) a carboxylic acryloyi monomer; (b) a sulfonic acryloyi monomer; (c) an amine acryloyi monomer; (d) a hydroxyl acryloyi monomer; (e) an alkyl acryloyi monomer; and (f) a polyalkylene hydroxyl acryloyi monomer; (ii) a divalent metallic crosslinking agent; and (c) a stabilizing agent is disclosed herein. Also provided are the use of said polymeric composition as a hydrogel coating material, a method of synthesizing the polymeric composition and the use of the hydrogel material.

公开(公告)号：US10975350B2

公开(公告)日：2021-04-13

申请号：US15780236

申请日：2016-11-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jackie Y. Ying ,  Nandanan Erathodiyil ,  Karthikeyan Narayanan ,  Andrew C. A. Wan

IPC: C12N5/00 ,  C12N5/0775 ,  B82Y30/00 ,  B82Y5/00

Abstract: A cell culture substrate comprising a substrate having a coating of a plurality of amine functionalized nanoparticles is disclosed. In one embodiment, the amine functionalized nanoparticle is a polymer of an acrylamide monomer, a cross-linker and an amine monomer. There is also provided a method of making the cell culture substrate either by drying the amine functionalized nanoparticles when spread onto the said substrate or by covalent linkages of the substrate with thiol terminated nanoparticles. In addition, there is provided a method of culturing stem cells on the cell culture substrate having a coating of a plurality of the amine functionalized nanoparticles thereon.

公开(公告)号：US09051418B2

公开(公告)日：2015-06-09

申请号：US14149493

申请日：2014-01-07

Applicant: Agency for Science, Technology and Research

Inventor： Karthikeyan Narayanan ,  Andrew Chwee Aun Wan ,  Jackie Y. Ying ,  Nandanan Erathodiyil

IPC: A61K31/765 ,  C08G65/00 ,  A61K31/08 ,  A61K31/16 ,  A61K31/69 ,  C07C235/08 ,  C07H15/08 ,  G01N33/50

CPC classification number: C08G65/00 ,  A61K31/08 ,  A61K31/16 ,  A61K31/69 ,  C07C235/08 ,  C07H15/08 ,  G01N33/5091

Abstract: There is provided a glucose-PEG conjugate comprising a PEG moiety conjugated to a linear glucose moiety at the C1 position of the glucose moiety. The glucose-PEG conjugate may be used to reduce glucose transport into a cell and may be used to treat a proliferative disorder.

Abstract translation: 提供了包含在葡萄糖部分的C1位上与线性葡萄糖部分缀合的PEG部分的葡萄糖-PEG缀合物。 葡萄糖-PEG轭合物可用于降低葡萄糖转运至细胞中，并可用于治疗增殖性疾病。

公开(公告)号：US20140193849A1

公开(公告)日：2014-07-10

申请号：US14149493

申请日：2014-01-07

Applicant: Agency for Science, Technology and Research

Inventor： Karthikeyan Narayanan ,  Andrew Chwee Aun Wan ,  Jackie Y. Ying ,  Nandanan Erathodiyil

IPC: C08G65/00 ,  G01N33/50

CPC classification number: C08G65/00 ,  A61K31/08 ,  A61K31/16 ,  A61K31/69 ,  C07C235/08 ,  C07H15/08 ,  G01N33/5091

Abstract: There is provided a glucose-PEG conjugate comprising a PEG moiety conjugated to a linear glucose moiety at the C1 position of the glucose moiety. The glucose-PEG conjugate may be used to reduce glucose transport into a cell and may be used to treat a proliferative disorder.

Abstract translation: 提供了包含在葡萄糖部分的C1位上与线性葡萄糖部分缀合的PEG部分的葡萄糖-PEG缀合物。 葡萄糖-PEG轭合物可用于降低葡萄糖转运至细胞中，并可用于治疗增殖性疾病。