公开(公告)号：US20150034242A1

公开(公告)日：2015-02-05

申请号：US14515446

申请日：2014-10-15

Applicant: Agency for Science, Technology and Research

Inventor： Jackie Y. Ying ,  Andrew C. A. Wan

IPC: B29C67/20 ,  A61L27/20 ,  A61L27/50 ,  B29C67/24

CPC classification number: B29C67/205 ,  A61L27/20 ,  A61L27/26 ,  A61L27/50 ,  A61L27/56 ,  A61L2400/18 ,  B29C67/246 ,  B29K2005/00 ,  B29K2096/00 ,  B29K2105/0005 ,  B29K2105/24 ,  B29K2105/251 ,  B29L2031/7532 ,  C08L5/08 ,  C08L5/04

Abstract: A porous scaffold is provided, which comprises tangled fibres. A porous scaffold can be formed by applying a fluid to fibres to entangle them. The fibres comprise a polyelectrolyte complex and a cross-linker. The cross-linker links polyelectrolytes within individual fibres and inhibits secondary polyelectrolyte complication between adjacent fibres.

Abstract translation: 提供多孔支架，其包括缠结的纤维。 多孔支架可通过向纤维施加流体以缠结它们而形成。 纤维包含聚电解质络合物和交联剂。 交联剂将聚电解质连接在单个纤维内并抑制相邻纤维之间的次级聚电解质并发症。

公开(公告)号：US10975350B2

公开(公告)日：2021-04-13

申请号：US15780236

申请日：2016-11-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jackie Y. Ying ,  Nandanan Erathodiyil ,  Karthikeyan Narayanan ,  Andrew C. A. Wan

IPC: C12N5/00 ,  C12N5/0775 ,  B82Y30/00 ,  B82Y5/00

Abstract: A cell culture substrate comprising a substrate having a coating of a plurality of amine functionalized nanoparticles is disclosed. In one embodiment, the amine functionalized nanoparticle is a polymer of an acrylamide monomer, a cross-linker and an amine monomer. There is also provided a method of making the cell culture substrate either by drying the amine functionalized nanoparticles when spread onto the said substrate or by covalent linkages of the substrate with thiol terminated nanoparticles. In addition, there is provided a method of culturing stem cells on the cell culture substrate having a coating of a plurality of the amine functionalized nanoparticles thereon.

公开(公告)号：US10449257B2

公开(公告)日：2019-10-22

申请号：US14356116

申请日：2012-11-05

Applicant: Agency for Science, Technology and Research

Inventor： Charlotte Hauser ,  Yihua Loo ,  Andrew C. A. Wan ,  Michael Reithofer

IPC: A61K47/36 ,  A61K31/7088 ,  A61K35/28 ,  A61K35/51 ,  A61K35/545 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/18 ,  A61K38/19 ,  A61K47/18 ,  A61L26/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  C08L5/00 ,  C08L5/04 ,  C08L5/08 ,  C08L5/10 ,  C08L5/16 ,  C08L71/02 ,  C08L89/00 ,  C12N5/00 ,  C12N15/113

Abstract: The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.

公开(公告)号：US10287553B2

公开(公告)日：2019-05-14

申请号：US14395811

申请日：2013-04-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Daniele Zink ,  Ming Ni ,  Karthikeyan Narayanan ,  Karthikeyan Kandasamy ,  Andrew C. A. Wan ,  Jackie Y. Ying

IPC: C12N5/074 ,  C12N5/00 ,  C12N5/0735 ,  C12N5/0775

Abstract: There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule having a catechol moiety or a polymer thereof; and growing a stem cell on said coated substrate surface in a growth medium.