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1.发明授权Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor 失效在前B细胞中选择性表达的核苷酸序列及其探针
公开(公告)号：US5182205A
公开(公告)日：1993-01-26
申请号：US701328
申请日：1991-05-08
IPC分类号： C07K14/47 , C12N15/11 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6876 , C07K14/47 , C12N15/11 , C12Q1/6886 , G01N33/574 , C12Q2600/112 , C12Q2600/158
摘要： The present invention provides nucleotide sequences which are selectively expressed in pre-B cells, probes comprising a polynucleotide hybridizing specifically to such a nucleotide sequence and methods for the production of such probes. These probes may be used for identifying pre-B cells. The invention further provides polypeptides translated from a transcript comprising a nucleotide sequence which is selectively expressed in pre-B cells or parts thereof, antibodies against these polypeptides and methods for the preparation and use of the polypeptides and antibodies raised against them.
摘要翻译： 本发明提供在前B细胞中选择性表达的核苷酸序列，包含与这种核苷酸序列特异性杂交的多核苷酸的探针和用于产生这种探针的方法。 这些探针可用于鉴定B细胞。 本发明进一步提供从转录本翻译的多肽，所述转录物包含在前B细胞或其部分选择性表达的核苷酸序列，针对这些多肽的抗体以及用于制备和使用针对它们产生的多肽和抗体的方法。
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2.发明授权Transgenic mammal carrying GANP gene transferred thereinto and utilization thereof 有权携带GANP基因的转基因哺乳动物及其利用公开(公告)号：US07919674B2
公开(公告)日：2011-04-05
申请号：US10534043
申请日：2003-11-07
申请人： Nobuo Sakaguchi
发明人： Nobuo Sakaguchi
IPC分类号： C12P21/00 , A01K67/00 , A01K67/033 , A01K67/027 , C12N5/00 , C12N5/02 , C12N5/07 , C12N5/10
CPC分类号： A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C07K16/40 , C07K2317/92 , C12N15/8509 , C12N2830/15 , C12N2830/85
摘要： It is an object of the present invention to provide a high affinity antibody effective as a diagnostic or therapeutic for various diseases; a transgenic mammal for producing the high affinity antibody; and a medicine comprising the high affinity antibody or a cell producing the high affinity antibody. According to the present invention, a transgenic mammal carrying a GANP gene transferred thereinto, its progeny, or a part thereof, and a method of producing a high affinity antibody using the same are provided.
摘要翻译： 本发明的目的是提供作为各种疾病的诊断或治疗有效的高亲和力抗体; 用于产生高亲和力抗体的转基因哺乳动物; 以及包含高亲和力抗体或产生高亲和力抗体的细胞的药物。 根据本发明，提供了携带转移有GANP基因的转基因哺乳动物，其后代或其一部分，以及使用其生产高亲和力抗体的方法。
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公开(公告)号：US06943237B2
公开(公告)日：2005-09-13
申请号：US10747133
申请日：2003-12-30
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
摘要翻译： 本发明的目的是提供具有激酶活性的新型蛋白质和编码所述蛋白质的基因。 根据本发明，提供了由序列表的SEQ ID No.1或3所示的氨基酸序列表示的GANP蛋白质，其涉及异常B细胞分化的信号转导 自身免疫状态，并且具有激酶活性，以及编码所述蛋白质的多核苷酸。
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4.发明申请Transgenic mammal carrying GANP gene transferred thereinto and utilization thereof 审中-公开携带GANP基因的转基因哺乳动物及其利用公开(公告)号：US20080233109A1
公开(公告)日：2008-09-25
申请号：US11889950
申请日：2007-08-17
申请人： Nobuo Sakaguchi
发明人： Nobuo Sakaguchi
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C07K16/40 , C07K2317/92 , C12N15/8509 , C12N2830/15 , C12N2830/85
摘要： It is an object of the present invention to provide a high affinity antibody effective as a diagnostic or therapeutic for various diseases; a transgenic mammal for producing the high affinity antibody; and a medicine comprising the high affinity antibody or a cell producing the high affinity antibody. According to the present invention, a transgenic mammal carrying a GANP gene transferred thereinto, its progeny, or a part thereof, and a method of producing a high affinity antibody using the same are provided.
摘要翻译： 本发明的目的是提供作为各种疾病的诊断或治疗有效的高亲和力抗体; 用于产生高亲和力抗体的转基因哺乳动物; 以及包含高亲和力抗体或产生高亲和力抗体的细胞的药物。 根据本发明，提供了携带转移有GANP基因的转基因哺乳动物，其后代或其一部分，以及使用其生产高亲和力抗体的方法。
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公开(公告)号：US20060057695A1
公开(公告)日：2006-03-16
申请号：US10961231
申请日：2004-10-12
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
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6.发明申请Transgenic mammal carrying ganp gene transferred thereinto and utilization thereof 有权携带甘油基因的转基因哺乳动物及其利用公开(公告)号：US20060236417A1
公开(公告)日：2006-10-19
申请号：US10534043
申请日：2003-11-07
申请人： Nobuo Sakaguchi
发明人： Nobuo Sakaguchi
IPC分类号： A01K67/027 , C12P21/04 , A61K39/395 , C07K16/44
CPC分类号： A01K67/0275 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C07K16/40 , C07K2317/92 , C12N15/8509 , C12N2830/15 , C12N2830/85
摘要： It is an object of the present invention to provide a high affinity antibody effective as a diagnostic or therapeutic for various diseases; a transgenic mammal for producing the high affinity antibody; and a medicine comprising the high affinity antibody or a cell producing the high affinity antibody. According to the present invention, a transgenic mammal carrying a GANP gene transferred thereinto, its progeny, or a part thereof, and a method of producing a high affinity antibody using the same are provided.
摘要翻译： 本发明的目的是提供作为各种疾病的诊断或治疗有效的高亲和力抗体; 用于产生高亲和力抗体的转基因哺乳动物; 以及包含高亲和力抗体或产生高亲和力抗体的细胞的药物。 根据本发明，提供了携带转移有GANP基因的转基因哺乳动物，其后代或其一部分，以及使用其生产高亲和力抗体的方法。
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公开(公告)号：US20060040372A1
公开(公告)日：2006-02-23
申请号：US11179624
申请日：2005-07-13
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the arnino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
摘要翻译： 本发明的目的是提供具有激酶活性的新型蛋白质和编码所述蛋白质的基因。 根据本发明，提供了由序列表的序列号1或3所示的氨基酸序列表示的GANP蛋白质，其参与了异常B细胞分化的信号转导 自身免疫状态，并且具有激酶活性，以及编码所述蛋白质的多核苷酸。
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公开(公告)号：US06825020B1
公开(公告)日：2004-11-30
申请号：US10638333
申请日：2003-08-12
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
IPC分类号： C12N912
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
摘要翻译： 本发明的目的是提供具有激酶活性的新型蛋白质和编码所述蛋白质的基因。 根据本发明，提供了由序列表的序列号1或3所示的氨基酸序列表示的GANP蛋白质，涉及自身免疫状态的异常B细胞分化的信号转换 并具有激酶活性，以及编码所述蛋白质的多核苷酸。
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公开(公告)号：US07667006B2
公开(公告)日：2010-02-23
申请号：US10582861
申请日：2004-03-09
CPC分类号： C07K16/1063 , C07K2317/76 , C07K2317/92 , G01N2333/16
摘要： The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10−9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny.
摘要翻译： 本发明旨在提供高亲和力的抗HIV抗体。 根据本发明，提供了与HIV的gp12糖蛋白结合并具有1.0×10-9（M）以下的解离常数（KD）值的抗体或其片段; 包含抗体或其片段的药物组合物; 以及产生抗HIV抗体或其片段的方法，包括用由SEQ ID NO：6所示的氨基酸序列组成的多肽免疫GANP转基因非人哺乳动物或其后代作为抗原并收集 来自所得哺乳动物或后代的抗体。
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公开(公告)号：US20080050365A1
公开(公告)日：2008-02-28
申请号：US10582861
申请日：2004-03-09
CPC分类号： C07K16/1063 , C07K2317/76 , C07K2317/92 , G01N2333/16
摘要： The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10−9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny
摘要翻译： 本发明旨在提供高亲和力的抗HIV抗体。 根据本发明，提供了结合HIV的gp12糖蛋白的抗体或其片段，其解离常数（KD）为1.0×10 -9（M）以下; 包含抗体或其片段的药物组合物; 以及产生抗HIV抗体或其片段的方法，包括用由SEQ ID NO：6所示的氨基酸序列组成的多肽免疫GANP转基因非人哺乳动物或其后代作为抗原并收集 来自所得哺乳动物或后代的抗体
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