Use of a tocopherol phosphate or one of its derivatives for the
preparation of cosmetic or pharmaceutical compositions and compositions
so obtained
    3.
    发明授权
    Use of a tocopherol phosphate or one of its derivatives for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained 失效
    使用生育酚磷酸酯或其衍生物之一用于制备如此获得的化妆品或药物组合物和组合物

    公开(公告)号:US5643597A

    公开(公告)日:1997-07-01

    申请号:US463237

    申请日:1995-06-05

    摘要: Use of a tocopherol phosphate, other than alpha-tocopherol phosphate, especially in its dl or d form, or one of its esters having general formula (I) in which: R' is hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, R'O is a tocopheryl radical; R" is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, or R"O is an oxyethylene chain, of formula (a) in which R.sub.4 and R.sub.5 are independently a hydrogen atom or a methyl radical, and n is an integer of 1 or over; R.sub.1, R.sub.2 and R.sub.3 are independently a hydrogen atom or a methyl radical, it being understood that R.sub.1, R.sub.2 and R.sub.3 cannot simultaneously be a methyl radical. A represents the groups (b), or (c). The invention also concerns the use of cosmetically or of pharmaceutically acceptable salts of said compound in the preparation of cosmetic or pharmaceutical, especially dermatological, composition characterized by having a reduced allergizing or irritating potential, or used in the prevention or treatment of allergic conditions, such as cutaneous allergy or bronchial or inflammatory asthma, or in the prevention or treatment of the harmful effects of free radicals.

    摘要翻译: 除了α-生育酚磷酸酯,特别是其dl或d形式之外的生育酚磷酸酯或其通式(I)的酯之一,其中:R'是氢原子,具有1至4个碳原子的烷基 原子,特别是甲基或乙基,R'O是生育酚基; R“是氢原子,具有1至4个碳原子的烷基,特别是甲基或乙基,或R'O是式(a)的氧化乙烯链,其中R 4和R 5是 独立地为氢原子或甲基,n为1以上的整数, R 1,R 2和R 3独立地为氢原子或甲基,应理解R1,R2和R3不能同时为甲基。 A代表组(b)或(c)。 本发明还涉及化妆品或药学上可接受的盐在制备化妆品或药物,特别是皮肤病学组合物中的用途,其特征在于具有降低的过敏或刺激性潜力,或用于预防或治疗过敏性疾病,例如 作为皮肤过敏或支气管炎或炎性哮喘,或用于预防或治疗自由基的有害作用。

    Use of a tocopherol phosphate or one of its derivatives, for the
preparation of cosmetic or pharmaceutical compositions and compositions
so obtained
    4.
    发明授权
    Use of a tocopherol phosphate or one of its derivatives, for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained 失效
    使用生育酚磷酸盐或其衍生物之一,用于制备如此获得的化妆品或药物组合物和组合物

    公开(公告)号:US5603949A

    公开(公告)日:1997-02-18

    申请号:US465610

    申请日:1995-06-05

    摘要: Use of a tocopherol phosphate, other than alpha-tocopherol phosphate, especially in its dl or d form, or one of its esters having general formula (I) in which: R' is hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, R'O is a tocopheryl radical; R" is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, or R"O is an oxyethylene chain, of formula (a) in which R.sub.4 and R.sub.5 are independently a hydrogen atom or a methyl radical, and n is an integer of 1 or over; R.sub.1, R.sub.2 and R.sub.3 are independently a hydrogen atom or a methyl radical, it being understood that R.sub.1, R.sub.2 and R.sub.3 cannot simultaneously be a methyl radical. A represents the groups (b), or (c). The invention also concerns the use of cosmetically or of pharmaceutically acceptable salts of said compound in the preparation of a cosmetic or pharmaceutical, especially dermatological, composition characterized by having a reduced allergizing or irritating potential, or used in the prevention or treatment of allergic conditions, such as cutaneous allergy or bronchial or inflammatory asthma, or in the prevention or treatment of the harmful effects of free radicals.

    摘要翻译: 除了α-生育酚磷酸酯,特别是其dl或d形式之外的生育酚磷酸酯或其通式(I)的酯之一,其中:R'是氢原子,具有1至4个碳原子的烷基 原子,特别是甲基或乙基,R'O是生育酚基; R“是氢原子,具有1至4个碳原子的烷基,特别是甲基或乙基,或R'O是式(a)的氧化乙烯链,其中R 4和R 5是 独立地为氢原子或甲基,n为1以上的整数, R 1,R 2和R 3独立地为氢原子或甲基,应理解R1,R2和R3不能同时为甲基。 A代表组(b)或(c)。 本发明还涉及化妆品或药学上可接受的盐在制备化妆品或药物,特别是皮肤病学组合物中的用途,其特征在于具有降低的过敏或刺激性潜力,或用于预防或治疗过敏性疾病, 如皮肤过敏或支气管炎或炎症性哮喘,或预防或治疗自由基的有害作用。