摘要:
The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility or for treating atherosclerosis are also disclosed.
摘要:
Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR &agr;, &dgr; and/or &ggr; mediated diseases, disorders and conditions.
摘要:
Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR .alpha., .delta. and/or .gamma. mediated diseases, disorders and conditions.
摘要:
FIG. 1 is a front, right and top perspective view of a fire extinguisher, showing my design. FIG. 2 is a rear, left and bottom perspective view thereof. FIG. 3 is a front elevation view thereof. FIG. 4 is a rear elevation view thereof. FIG. 5 is a left side elevation view thereof. FIG. 6 is a right side elevation view thereof. FIG. 7 is a top plan view thereof; and, FIG. 8 is a bottom plan view thereof. The broken lines depict portions of the fire extinguisher that form no part of the claimed design.
摘要:
The applications and medical devices of Midkine in the field of biotechnology are described in this invention. This invention describes the applications of the protein as follow in (a) or (b) in preparing drugs for promoting cartilage growth or treating cartilage diseases, the protein as a growth factor for promoting chondrocyte proliferation, or medical devices containing this protein: (a) the protein whose amino acid sequence is shown as SEQ ID NO.1; (b) the proteins whose amino acid sequence have at least 60% homology comparing with amino acid sequence described in (a). The present invention is different from the present knowledge of MK and its related proteins. The experimental results demonstrated that MK promotes proliferation of three types of chondrocytes and is used for preparing drugs for treating cartilage disease. It may provide new therapy for treating cartilage diseases clinically, and new technology for expansion of chondrocytes in vitro for cartilage tissue engineering.
摘要翻译:本发明描述了Midkine在生物技术领域的应用和医疗设备。 本发明描述了如下(a)或(b)中的蛋白质在制备用于促进软骨生长或治疗软骨疾病的药物中的应用,所述蛋白质作为促进软骨细胞增殖的生长因子,或含有该蛋白质的医学装置:(a )其氨基酸序列显示为SEQ ID NO.1的蛋白质; (b)与(a)中所述的氨基酸序列相比,其氨基酸序列具有至少60%同源性的蛋白质。 本发明与MK及其相关蛋白质的现有知识不同。 实验结果表明,MK促进三种软骨细胞增殖,用于制备治疗软骨疾病的药物。 可能提供临床治疗软骨疾病的新疗法,软骨组织工程体外软骨细胞扩增的新技术。
摘要:
An acoustic transducer assembly includes: a carrier configured to be disposed in an earth formation, the carrier having a carrier axis; an array of transducer elements forming at least a semicircular shape, the array configured to emit acoustic signals in a radial direction relative to the carrier axis; and a circuit coupled to the array and configured to actuate a subset of the transducer elements and emit an acoustic beam therefrom, the circuit configured to actuate the subsets as a phased array to electronically rotate the acoustic beam about the carrier axis.
摘要:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, L1, R3, and R11 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要:
A DC to DC converter includes a control circuit, a gate driver circuit, and a power stage circuit. The control circuit receives and compares a DC output voltage. When the DC output voltage lower than a first threshold voltage, a PWM signal with a first frequency is outputted, and when the DC output voltage higher than the first threshold voltage, the PWM signal with a second frequency is outputted. The second frequency is higher than the first frequency. The gate driver circuit receives the PWM signal and converts the PWM signal to a first driving signal and a second driving signal. The power stage circuit converts a DC input voltage to the DC output voltage according to the first driving signal and the second driving signal.
摘要:
The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4 I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要:
In one embodiment of the invention, an integrated circuit such as a programmable logic device includes volatile memory, nonvolatile memory, and a data shift register for reading data from the nonvolatile memory and for reading data from and writing data to the volatile memory. A built in self test (BIST) circuit is operable to test the nonvolatile memory without the data shift register reading data from the nonvolatile memory. The BIST circuit may include a finite state machine for performing at least one of the following tests on the nonvolatile memory: bulk erase, bulk program; margin bulk program; and/or margin bulk erase. A memory controller responsive to the finite state machine is operable to write data to and read data from the nonvolatile memory during testing of the nonvolatile memory.