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33 条记录 (耗时 0.022 秒)

    Further extractions of metals in carbon dioxide and chelating agents therefor
    3.
    发明授权
    Further extractions of metals in carbon dioxide and chelating agents therefor 失效
    进一步提取二氧化碳中的金属及其螯合剂

    公开(公告)号：US5872257A

    公开(公告)日：1999-02-16

    申请号：US831999

    申请日：1997-04-01

    申请人： Eric J. Beckman ,  Alan J. Russell

    发明人： Eric J. Beckman ,  Alan J. Russell

    IPC分类号： C07D213/38 ,  C23C22/02 ,  C07D401/06

    CPC分类号： C23F11/16 ,  B82Y30/00 ,  C07D213/38 ,  C23C22/02 ,  Y02P20/544

    摘要： The present invention provides a chelating agent suitable for forming coordinated complexes with a metal in liquid and supercritical carbon dioxide of covalently bonded (i) a chelating group selected from the group consisting of a dithio carbamate, a thiol group, and a picolyl amine group, (ii) a non-electron withdrawing spacer group selected from (CH.sub.2).sub.x ; and (iii) a CO.sub.2 -soluble functional group selected from (CF.sub.2 CF.sub.2 O).sub.X, (CF.sub.2 O).sub.X, (CF.sub.2).sub.X, and �CF.sub.2 (CF.sub.3 FO)!.sub.x. X is selected to be greater or equal to 3 and to minimize the electron withdrawing effect of the CO.sub.2 -soluble functional group and to achieve a chelating agent solubility of at least a 10.sup.-3 gm/gm CO.sub.2. A solubility of at least 10.sup.-2 gm/gm CO.sub.2 is attained at a temperature in the range of approximately 0.degree. to 100.degree. C. and a pressure of approximately 500 to 5000 psi.

    摘要翻译： 本发明提供了一种螯合剂，其适用于与液态的金属和超临界二氧化碳形成配位络合物，共价键合（i）选自二硫代氨基甲酸酯，硫醇基和吡啶甲基胺基的螯合基团， （ii）选自（CH 2）x的非吸电子间隔基团; 和（iii）选自（CF 2 CF 2 O）X，（CF 2 O）X，（CF 2）X和[CF 2（CF 3））x的二氧化碳可溶性官能团。 X选择为大于或等于3，并且使二氧化碳可溶性官能团的吸电子效应最小化，并达到至少10-3克/克二氧化碳的螯合剂溶解度。 在约0℃至100℃的温度和约500至5000psi压力下的温度下可获得至少10-2克/克CO 2的溶解度。

    Extraction of metals in carbon dioxide and chelating agents therefor
    4.
    发明授权
    Extraction of metals in carbon dioxide and chelating agents therefor 失效
    二氧化碳和螯合剂中金属的萃取

    公开(公告)号：US5641887A

    公开(公告)日：1997-06-24

    申请号：US223105

    申请日：1994-04-01

    申请人： Eric J. Beckman ,  Alan J. Russell

    发明人： Eric J. Beckman ,  Alan J. Russell

    IPC分类号： C07D213/38 ,  C23C22/02 ,  C07D401/06

    CPC分类号： B82Y30/00 ,  C07D213/38 ,  C23C22/02 ,  Y02P20/544

    摘要： The present invention provides a chelating agent suitable for chelating metals metals in liquid or supercritical carbon dioxide. The chelating agent comprises generally a conventional chelating group and a CO.sub.2 -soluble functional group covalently attached to the chelating group. Examples of suitable CO.sub.2 -soluble functional groups include fluorinated polyether groups, silicone groups, fluorinated polyalkyl groups, phosphazene groups and fluorinated polyacrylate groups. The present invention also provides a method of extracting a metal from a matrix containing at least one other material and the metal using such CO.sub.2 -soluble chelating agents.

    摘要翻译： 本发明提供了一种适用于螯合液态或超临界二氧化碳金属金属的螯合剂。 螯合剂通常包括共价连接到螯合基团的常规螯合基团和二氧化碳可溶性官能团。 合适的二氧化碳可溶性官能团的实例包括氟化聚醚基团，硅氧烷基团，氟化聚烷基基团，磷腈基团和氟化聚丙烯酸酯基团。 本发明还提供一种从含有至少一种其它材料的基质中提取金属的方法，并且使用这种可溶于二氧化碳的螯合剂从金属中提取金属。

    Protein-containing polymers and a method of synthesis of protein-containing polymers in organic solvents
    5.
    发明授权
    Protein-containing polymers and a method of synthesis of protein-containing polymers in organic solvents 失效
    含蛋白质的聚合物和在有机溶剂中合成含蛋白质的聚合物的方法

    公开(公告)号：US5482996A

    公开(公告)日：1996-01-09

    申请号：US165712

    申请日：1993-12-08

    申请人： Alan J. Russell ,  Eric J. Beckman

    发明人： Alan J. Russell ,  Eric J. Beckman

    IPC分类号： C08G18/64 ,  C08G63/46 ,  C08L89/00 ,  C08G63/48

    CPC分类号： C08G18/6446 ,  C08G63/46

    摘要： The present invention provides protein-containing polymers and a general method of incorporating biologically active proteins into a polymer matrix via copolymerization in organic solvents. Preferably, the protein is an active enzyme which maintains its activity in the polymeric matrix. The proteins are first solubilized in organic solvents by covalent attachment of a modifying moiety such as a polyalkylene oxide. The polyalkylene oxide is functionalized with a functional group enabling copolymerization in organic solvents with an organic-soluble comonomer.

    摘要翻译： 本发明提供含蛋白质的聚合物和通过在有机溶剂中共聚合将生物活性蛋白质并入聚合物基质的一般方法。 优选地，蛋白质是在聚合物基质中保持其活性的活性酶。 首先通过共价连接修饰部分如聚环氧烷将蛋白质溶解在有机溶剂中。 聚氧化烯官能化官能团，可在有机溶剂中与有机溶解的共聚单体共聚。

    Wound healing polymeric networks
    8.
    发明授权
    Wound healing polymeric networks 有权
    伤口愈合聚合物网络

    公开(公告)号：US08029774B2

    公开(公告)日：2011-10-04

    申请号：US11479627

    申请日：2006-07-01

    申请人： Eric J. Beckman ,  Stephen F. Badylak ,  Alan H. Wells ,  Jianying Zhang ,  Donald Freytes

    发明人： Eric J. Beckman ,  Stephen F. Badylak ,  Alan H. Wells ,  Jianying Zhang ,  Donald Freytes

    IPC分类号： A61K31/74 ,  A61K38/39 ,  A61K38/00 ,  A61K47/48 ,  A61F2/00 ,  A61P17/02 ,  C08G63/48 ,  C08G63/91 ,  C08L89/00

    CPC分类号： C08G18/3821 ,  A61K31/28 ,  A61K38/39 ,  A61K45/06 ,  A61K47/59 ,  A61K47/60 ,  A61L26/0019 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/104 ,  A61L2300/214 ,  A61L2300/252 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/418 ,  C08G18/10 ,  C08G18/3206 ,  C08G18/3218 ,  C08G18/4833 ,  C08G18/771 ,  C08G18/8022 ,  C08G2230/00

    摘要： A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the bioactive agent thereto. The first polymerizing molecule is preferably biocompatible. The polymerizing molecule can, for example. be dihydroxyphenyl-L-alanine (DOPA) or tyrosine. The composition can also include a second component synthesized by reacting at least one core molecule having a plurality of reactive hydrogen groups with at least one multi-isocyanate functional molecule to create a conjugate including terminal isocyanate groups. The conjugate molecule is reacted with a second polymerizing molecule that is adapted to undergo a free radical polymerization. The second polymerizing molecule includes a reactive hydrogen to react with the isocyanate groups of the conjugate. The second polymerizing molecule retains the ability to undergo the free radical polymerization after reaction with the conjugate. In several embodiments, the first polymerizing molecule and the second polymerizing molecule are the same and dihydroxyphenyl-L-alanine (DOPA) or tyrosine.

    摘要翻译： 组合物包含共价连接到适于进行自由基聚合的第一聚合分子的至少一种生物活性剂。 第一聚合分子保留在生物活性剂附着后进行自由基聚合的能力。 第一聚合分子优选是生物相容的。 聚合分子可以，例如。 是二羟基苯基-L-丙氨酸（DOPA）或酪氨酸。 组合物还可以包括通过使具有多个反应性氢基团的至少一个核心分子与至少一个多异氰酸酯官能分子反应以产生包含末端异氰酸酯基团的缀合物而合成的第二组分。 共轭分子与适于进行自由基聚合的第二聚合分子反应。 第二聚合分子包括与偶联物的异氰酸酯基反应的反应性氢。 第二聚合分子保留在与缀合物反应后进行自由基聚合的能力。 在几个实施方案中，第一聚合分子和第二聚合分子是相同的，并且是二羟基苯基-L-丙氨酸（DOPA）或酪氨酸。

    Synthesis of hydrogen peroxide
    9.
    发明授权
    Synthesis of hydrogen peroxide 失效
    合成过氧化氢

    公开(公告)号：US06656446B1

    公开(公告)日：2003-12-02

    申请号：US09560489

    申请日：2000-04-28

    申请人： Eric J. Beckman ,  Dan Hâncu

    发明人： Eric J. Beckman ,  Dan Hâncu

    IPC分类号： C01B15026

    CPC分类号： C07D209/48 ,  C01B15/026 ,  C07C17/2632 ,  C07C17/269 ,  C07F9/5357 ,  C07C25/13

    摘要： A method for synthesizing hydrogen peroxide comprises the step of: mixing an analog of a secondary alcohol that is soluble with carbon dioxide with a free radical initiator and oxygen in carbon dioxide to generate hydrogen peroxide. Another method of synthesizing hydrogen peroxide comprises the step of: mixing hydrogen, oxygen and a CO2-philic catalyst in carbon dioxide phase. The CO2-philic catalyst is soluble or miscible in carbon dioxide and is suitable to catalyze the reaction of hydrogen and oxygen to produce hydrogen peroxide. The method also comprises the step of reacting the hydrogen and oxygen to produce hydrogen peroxide.

    摘要翻译： 合成过氧化氢的方法包括以下步骤：将可溶于二氧化碳的仲醇的类似物与自由基引发剂和氧气在二氧化碳中混合以产生过氧化氢。 合成过氧化氢的另一种方法包括以下步骤：在二氧化碳相中混合氢气，氧气和二氧化碳亲合催化剂。 二氧化碳亲和催化剂在二氧化碳中是可溶的或可混溶的，适用于催化氢和氧反应产生过氧化氢。 该方法还包括使氢和氧反应产生过氧化氢的步骤。

    Medical adhesive and methods of tissue adhesion
    10.
    发明授权
    Medical adhesive and methods of tissue adhesion 有权
    医用粘合剂和组织粘附方法

    公开(公告)号：US07264823B2

    公开(公告)日：2007-09-04

    申请号：US10361431

    申请日：2003-02-10

    申请人： Eric J. Beckman ,  Michael Buckley ,  Sudha Agarwal ,  Jianying Zhang

    发明人： Eric J. Beckman ,  Michael Buckley ,  Sudha Agarwal ,  Jianying Zhang

    IPC分类号： A61F13/02 ,  A61L15/16

    CPC分类号： C09J175/04 ,  A61K31/785 ,  C08G18/6674 ,  C08G18/771

    摘要： An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group. Preferably, the functional groups are hydroxyl groups. The multi-functional precursor compounds are biocompatible. Multi-amine functional precursors of the multi-isocyanate functional molecules are also biocompatible. As discussed, above, the mixture of molecules preferably has an average isocyanate functionality of at least 2.1 and, more preferably, has an average isocyanate functionality of at least 2.5. As also described above, the mixture of molecules preferably has a viscosity in the range of approximately 1 to approximately 100 centipoise. The mixture of molecules forms a crosslinked polymer network upon contact with the organic tissue in the presence of water. The crosslinked polymer network is biocompatible and biodegradable. The crosslinked polymer network degrades into degradation products including the precursor molecules and the multi-amine functional precursors.

    摘要翻译： 一种粘合剂，其包括通过使多异氰酸酯官能分子与多官能前体分子反应形成的异氰酸酯封端分子的混合物，所述多功能前体分子包括选自羟基，伯氨基和仲氨基的末端官能团。 优选地，官能团是羟基。 多功能前体化合物是生物相容的。 多异氰酸酯官能分子的多胺官能前体也是生物相容的。 如上所述，分子的混合物优选具有至少2.1的平均异氰酸酯官能度，更优选具有至少2.5的平均异氰酸酯官能度。 如上所述，分子的混合物优选具有在约1至约100厘泊范围内的粘度。 分子的混合物在水的存在下与有机组织接触时形成交联的聚合物网络。 交联聚合物网络是生物相容性和可生物降解的。 交联聚合物网络降解成包括前体分子和多胺官能前体的降解产物。