公开(公告)号：US12030963B2

公开(公告)日：2024-07-09

申请号：US17198081

申请日：2021-03-10

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： V. Prasad Shastri ,  Aurélien Forget

IPC: A61K31/715 ,  A61K8/73 ,  A61K47/36 ,  A61L31/12 ,  A61Q90/00 ,  C08B37/00 ,  C08B37/08 ,  C08H1/00 ,  C08L5/00 ,  C08L5/12 ,  C10M107/36 ,  C12N5/00

CPC classification number: C08B37/006 ,  A61K8/73 ,  A61K31/715 ,  A61K47/36 ,  A61L31/125 ,  A61Q90/00 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0039 ,  C08B37/0042 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08H1/00 ,  C08L5/00 ,  C08L5/12 ,  C10M107/36 ,  C12N5/0068 ,  C12N2533/50 ,  C12N2533/70 ,  C08L5/12 ,  C08L5/12 ,  C08L5/12 ,  C08L5/00

Abstract: The present invention discloses a matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid group.

公开(公告)号：US10968285B2

公开(公告)日：2021-04-06

申请号：US16000370

申请日：2018-06-05

Applicant: ALBERT-LUDWIGS UNIVERSITÄT FREIBURG

Inventor： V. Prasad Shastri ,  Aurelien Forget

IPC: C08B37/00 ,  A61K31/175 ,  A61K47/36 ,  A61L31/12 ,  C08L5/00 ,  C12N5/00 ,  C08B37/08 ,  C08H1/00 ,  C08L5/12 ,  A61K31/715 ,  A61K8/73 ,  A61Q90/00 ,  C10M107/36

Abstract: The present invention discloses a matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid group.

公开(公告)号：US09840593B2

公开(公告)日：2017-12-12

申请号：US15134739

申请日：2016-04-21

Applicant: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG

Inventor： V. Prasad Shastri ,  Maziar Matloubigharagozloo

IPC: C08G77/00 ,  C08G77/445 ,  A61L31/06 ,  A61L31/14 ,  A61L27/50 ,  A61L29/06 ,  C08G18/61 ,  C08G18/42 ,  C08G18/73 ,  A61L27/18 ,  A61L29/14

CPC classification number: C08G77/445 ,  A61L27/18 ,  A61L27/50 ,  A61L29/06 ,  A61L29/14 ,  A61L31/06 ,  A61L31/14 ,  A61L2400/16 ,  C08G18/428 ,  C08G18/61 ,  C08G18/73 ,  C08G2280/00 ,  C08L83/04

Abstract: Phase segregated block-copolymer based on repeating structural elements represented by formula I wherein PHA represents at least one block based on one or more α-hydroxy acids, PDAS represents a central block based on a dialkylsiloxane, the PDAS block has a weight average molecular weight in the range of from 4000 to 10000, the blocks PHA have a weight average molecular weight in the range of from 2000 to 10 000, the phase segregated block copolymer has a weight average molecular weight of from 40 000 to 120 000.

公开(公告)号：US09441051B2

公开(公告)日：2016-09-13

申请号：US14085244

申请日：2013-11-20

Applicant: Albert Ludwigs Universität Freiburg

Inventor： V. Prasad Shastri ,  Aurelien Forget ,  Florian Mieβmer

IPC: C08B37/00 ,  A61K8/73 ,  C08B37/08 ,  A61Q5/00 ,  A61Q19/00

CPC classification number: C08B37/00 ,  A61K8/73 ,  A61K2800/10 ,  A61Q5/00 ,  A61Q19/00 ,  C08B37/003 ,  C08B37/0039 ,  C08B37/0042 ,  C08B37/0072 ,  C08B37/0075

Abstract: The present invention discloses a matrix comprising a modified primary hydroxyl groups containing polysaccharide comprising repeating disaccharide units wherein in at least part of the disaccharide units the primary hydroxyl group is replaced by functional groups selected from halide groups or groups comprising sulfur or phosphorus atoms, like e.g. sulfate groups, sulfonate groups, phosphonate groups and phosphate groups.

Abstract translation: 本发明公开了一种基质，其包含含有重复二糖单元的改性伯羟基含多糖的基团，其中在至少部分二糖单元中，伯羟基被选自卤化物基团或包含硫或磷原子的基团所取代。 硫酸基，磺酸酯基，膦酸酯基和磷酸酯基。

公开(公告)号：US20220411756A1

公开(公告)日：2022-12-29

申请号：US17835243

申请日：2022-06-08

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： V. Prasad Shastri ,  Aurélien Forget

IPC: C12N5/077 ,  C12N5/00

Abstract: The present invention discloses an extracellular matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid.