-
1.发明申请HYALURONIC ACID DERIVATIVE AND NEURAL STEM CELLS FOR SCI AND PNT REGENERATION 审中-公开用于SCI和PNT再生的羟丙酸衍生物和神经干细胞公开(公告)号：US20100136081A1
公开(公告)日：2010-06-03
申请号：US12470116
申请日：2009-05-21
CPC分类号： A61L27/20 , A61L27/383 , A61L27/3878 , A61L27/3895 , C08L5/08
摘要： A biomaterial for the treatment of spinal cord or of peripheral nerve injury, obtainable by: a) treating a hyaluronic acid derivative with a coating solution promoting Neuronal Stem Cells adhesion, branching and differentiation; b) contacting isolated Neuronal Stem Cells with the hyaluronic acid derivative obtained from step a) and culturing and expanding the absorbed cells in the presence of growth or neurotrophic factors selected from βFGF (basic fibroblast growth factor), CNTF (ciliary neurotrophic factor), BDNF (brain derived neurotrophic factor) and GDNF (glial derived neurotrophic factor) or mixtures thereof.
摘要翻译： 用于治疗脊髓或周围神经损伤的生物材料，其可通过以下方法获得：a）用涂覆溶液处理透明质酸衍生物，促进神经元干细胞粘附，分支和分化; b）使分离的神经元干细胞与从步骤a）获得的透明质酸衍生物接触，并在生长或神经营养因子存在下培养和扩增所吸收的细胞，所述生长或神经营养因子选自FGF（碱性成纤维细胞生长因子），CNTF（睫状神经营养因子） ，BDNF（脑源性神经营养因子）和GDNF（胶质衍生的神经营养因子）或其混合物。
-
2.发明申请公开(公告)号：US20130053324A1
公开(公告)日：2013-02-28
申请号：US13642081
申请日：2011-04-19
IPC分类号： C07K7/06 , A61K47/42 , C07K14/00 , C12N5/071 , A61P25/00 , A61K38/08 , A61K38/10 , D02G3/22 , C07K7/08 , C12N5/0797 , B82Y5/00
CPC分类号： B82Y5/00 , B82Y15/00 , C07K7/06 , C07K7/08 , C12N5/0068 , C12N2533/50
摘要： There is described a group of novel self-assembling peptides (SAPs), comprising biotinylated and unbiotinylated sequences, hybrid peptide-peptoid sequences, branched sequences for a total of 48 tested motifs, showing a heterogeneous ensemble of spontaneously self-assembled structures at the nano- and microscale, ranging from short tabular fibers to twisted ribbons, nanotubes and hierarchical self-assembled micrometer-long sheets. Specifically, the SAPs according to the present invention which initially spontaneous assemble, surprisingly form stable solid scaffolds upon exposure to neutral pH buffer. Further these SAPs allow adhesion, proliferation and differentiation of murine and human neural stem cells and have self-healing propensity. They also did not exert toxic effects in the central nervous system, can stop bleeding and foster nervous regeneration. Therefore, the SAPs according to the present invention are improved biomaterials, a highly valid and useful alternative which may replace the known SAPs, thus overcoming the disadvantages related thereto.
摘要翻译： 描述了一组新的自组装肽（SAP），其包含生物素化和未生物素化的序列，杂合肽 - 肽类序列，总共48个测试的基序的支链序列，显示在纳米的自发自组装结构的异质组合 - 微尺度，从短片状纤维到扭曲带，纳米管和分级自组装千分尺长片。 具体地，根据本发明的初始自发组装的SAP在暴露于中性pH缓冲液时令人惊奇地形成稳定的固体支架。 此外，这些SAP允许鼠和人神经干细胞的粘附，增殖和分化，并具有自我修复倾向。 他们也没有在中枢神经系统发挥毒性作用，可以止血，促进神经再生。 因此，根据本发明的SAP是改进的生物材料，这是一种非常有效和有用的替代方案，其可以替代已知的SAP，从而克服与之相关的缺点。
-
公开(公告)号：US08722850B2
公开(公告)日：2014-05-13
申请号：US13642081
申请日：2011-04-19
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07F7/00 , C07K14/00 , C12N5/00 , C12N5/07 , C12N5/071 , C12N5/073 , C12N5/077 , C12N5/0775
CPC分类号： B82Y5/00 , B82Y15/00 , C07K7/06 , C07K7/08 , C12N5/0068 , C12N2533/50
摘要： There is described a group of novel self-assembling peptides (SAPs), comprising biotinylated and unbiotinylated sequences, hybrid peptide-peptoid sequences, branched sequences for a total of 48 tested motifs, showing a heterogeneous ensemble of spontaneously self-assembled structures at the nano- and microscale, ranging from short tabular fibers to twisted ribbons, nanotubes and hierarchical self-assembled micrometer-long sheets. Specifically, the SAPs according to the present invention which initially spontaneous assemble, surprisingly form stable solid scaffolds upon exposure to neutral pH buffer. Further these SAPs allow adhesion, proliferation and differentiation of murine and human neural stem cells and have self-healing propensity. They also did not exert toxic effects in the central nervous system, can stop bleeding and foster nervous regeneration. Therefore, the SAPs according to the present invention are improved biomaterials, a highly valid and useful alternative which may replace the known SAPs, thus overcoming the disadvantages related thereto.
摘要翻译： 描述了一组新的自组装肽（SAP），其包含生物素化和未生物素化的序列，杂合肽 - 肽类序列，总共48个测试的基序的支链序列，显示在纳米的自发自组装结构的异质组合 - 微尺度，从短片状纤维到扭曲带，纳米管和分级自组装千分尺长片。 具体地，根据本发明的初始自发组装的SAP在暴露于中性pH缓冲液时令人惊奇地形成稳定的固体支架。 此外，这些SAP允许鼠和人神经干细胞的粘附，增殖和分化，并具有自我修复倾向。 他们也没有在中枢神经系统发挥毒性作用，可以止血，促进神经再生。 因此，根据本发明的SAP是改进的生物材料，这是一种非常有效和有用的替代方案，其可以替代已知的SAP，从而克服与之相关的缺点。
-
公开(公告)号：US08022178B2
公开(公告)日：2011-09-20
申请号：US11904278
申请日：2007-09-26
申请人： Akihiro Horii , Shuguang Zhang , Xiumei Wang , Fabrizio Gelain
发明人： Akihiro Horii , Shuguang Zhang , Xiumei Wang , Fabrizio Gelain
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K47/66 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/414 , B82Y5/00 , C07K14/78
摘要： The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not mediate self-assembly in isolated form, wherein the second amino acid domain comprises at least one minimal biologically active sequence. Such self-assembling peptides are described herein as “modified self-assemblingpeptides.” The present invention also provides pharmaceutical compositions, kits and matrices comprising a modified self-assembling peptide, and methods of using and making such compositions, kits and matrices.
摘要翻译： 本发明提供了一种自组装肽，其包含：（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替疏水和亲水氨基酸，并且自组装成宏观结构，当 以未经修改的形式出现; 和（b）不以分离形式介导自组装的第二氨基酸结构域，其中第二氨基酸结构域包含至少一个最小生物活性序列。 这种自组装肽在本文中被描述为“修饰的自组装肽”。本发明还提供了包含修饰的自组装肽的药物组合物，试剂盒和基质，以及使用和制备这种组合物，试剂盒和基质的方法。
-
公开(公告)号：US09273101B2
公开(公告)日：2016-03-01
申请号：US14005442
申请日：2012-03-14
CPC分类号： C07K14/001 , C07K7/06 , C07K7/08 , C07K14/78 , C12N5/0018 , G01N33/5005 , Y10T442/30
摘要： Functionalized self-assembling peptides suitable for obtaining hydrogels for use in a wide range of applications in the biomedical field, such as for the development of biomaterials for regenerative medicine and basic science research are described.
摘要翻译： 描述了适用于获得用于生物医学领域广泛应用的水凝胶的功能化自组装肽，例如用于再生医学和基础科学研究的生物材料的开发。
-
公开(公告)号：US20140066387A1
公开(公告)日：2014-03-06
申请号：US14005442
申请日：2012-03-14
CPC分类号： C07K14/001 , C07K7/06 , C07K7/08 , C07K14/78 , C12N5/0018 , G01N33/5005 , Y10T442/30
摘要： The present invention concerns the field of functionalized self-assembling peptides suitable for obtaining hydrogels for use in a wide range of applications in the biomedical field, such as for the development of biomaterials for regenerative medicine and basic science research.
摘要翻译： 本发明涉及适用于获得用于生物医学领域广泛应用的水凝胶的功能化自组装肽的领域，例如用于再生医学和基础科学研究的生物材料的开发。
-
公开(公告)号：US20090162437A1
公开(公告)日：2009-06-25
申请号：US11904278
申请日：2007-09-26
申请人： Akihiro Horii , Shuguang Zhang , Xiumei Wang , Fabrizio Gelain
发明人： Akihiro Horii , Shuguang Zhang , Xiumei Wang , Fabrizio Gelain
CPC分类号： C07K14/001 , A61K47/66 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/414 , B82Y5/00 , C07K14/78
摘要： The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not mediate self-assembly in isolated form, wherein the second amino acid domain comprises at least one minimal biologically active sequence. Such self-assembling peptides are described herein as “modified self-assembling peptides.” The present invention also provides pharmaceutical compositions, kits and matrices comprising a modified self-assembling peptide, and methods of using and making such compositions, kits and matrices.
摘要翻译： 本发明提供了一种自组装肽，其包含：（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替疏水和亲水氨基酸，并且自组装成宏观结构，当 以未经修改的形式出现; 和（b）不以分离形式介导自组装的第二氨基酸结构域，其中第二氨基酸结构域包含至少一个最小生物活性序列。 这种自组装肽在本文中被描述为“修饰的自组装肽”。 本发明还提供了包含修饰的自组装肽的药物组合物，试剂盒和基质，以及使用和制备这种组合物，试剂盒和基质的方法。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.022 秒)
