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公开(公告)号：US4540661A
公开(公告)日：1985-09-10
申请号：US469375
申请日：1983-02-24
CPC分类号： C12P13/008 , C12R1/025 , C12R1/465 , Y10S435/829 , Y10S435/886
摘要： Antibiotic U-66,026 is produced in a fermentation under controlled conditions using the microorganism Alcaligenes sp., NRRL B-15269. Enhanced fermentation of titers U-66,026 are obtained when Alcaligenes sp., NRRL B-15269, is cultivated in mixture with Streptomyces plicatus strain 395, NRRL 15273.Antibiotic U-66,026 is a useful antibiotic which has antifungal activity.
摘要翻译： 在受控条件下使用微生物产碱杆菌属，NRRL B-15269在发酵中产生抗生素U-66,026。 当产碱杆菌属物种NRRL B-15269与Streptomyces plicatus菌株395，NRRL 15273的混合培养时获得增强的滴度U-66,026的发酵。抗生素U-66,026是具有抗真菌活性的有用的抗生素。
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公开(公告)号：US4259450A
公开(公告)日：1981-03-31
申请号：US772552
申请日：1977-02-28
CPC分类号： A01N63/02
摘要： Antibiotic acanthomycin (U-53,827) produced by the controlled fermentation of the microorganism Streptomyces espinosus subsp. acanthus, NRRL 11081. This antibiotic and its base addition salts are active against Gram-positive bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.
摘要翻译： 通过微生物链霉菌Streptomyces espinosus subsp。的控制发酵产生的抗生素棘皮瘤霉素（U-53,827） 鳄梨，NRRL 11081.该抗生素及其碱加成盐对革兰氏阳性菌具有活性。 因此，它们可以用于各种环境中以消除或控制这些细菌。
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公开(公告)号：US3998698A
公开(公告)日：1976-12-21
申请号：US674860
申请日：1976-04-08
CPC分类号： C07H5/04 , Y10S435/886
摘要： Antibiotic U-51,640 produced by the controlled fermentation of the microorganism Streptomyces ficellus Dietz, sp. n., NRRL 8067. This antibiotic and its acid addition salts are active against Gram-positive and Gram-negative bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.
摘要翻译： 通过微生物链霉菌（Streptomyces ficellus Dietz）的受控发酵产生的抗生素U-51,640。 这种抗生素及其酸加成盐对革兰氏阳性和革兰氏阴性菌具有活性。 因此，它们可以用于各种环境中以消除或控制这些细菌。
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公开(公告)号：US3993748A
公开(公告)日：1976-11-23
申请号：US542226
申请日：1975-01-20
CPC分类号： C07G11/00 , Y10S435/803 , Y10S435/886
摘要： New antibiotic U-47,929 produced by the controlled fermentation of the new microorganism Streptomyces ficellus Dietz, sp. n., NRRL 8067. This antibiotic and its acid-addition salts are active against Gram-positive bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.
摘要翻译： 通过新型微生物链霉菌（Streptomyces ficellus Dietz）的受控发酵产生的新型抗生素U-47,929。 这种抗生素及其酸加成盐对革兰氏阳性菌有活性。 因此，它们可以用于各种环境中以消除或控制这些细菌。
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公开(公告)号：US3969515A
公开(公告)日：1976-07-13
申请号：US556573
申请日：1975-03-10
摘要： New antibiotic U-48,266 produced by the controlled fermentation of the microorganism Streptomyces ficellus Dietz, sp. n., NRRL 8067. This antibiotic and its acid and base addition salts are active against Gram-positive and Gram-negative bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.
摘要翻译： 通过微生物链霉菌（Streptomyces ficellus Dietz）的受控发酵产生的新型抗生素U-48,266。 这种抗生素及其酸和碱加成盐对革兰氏阳性和革兰氏阴性菌具有活性。 因此，它们可以用于各种环境中以消除或控制这些细菌。
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公开(公告)号：US4464466A
公开(公告)日：1984-08-07
申请号：US467976
申请日：1983-02-18
CPC分类号： C07H19/10 , C07H19/20 , C12P19/305 , C12P19/32 , C12P19/38 , C12R1/465 , Y10S435/886
摘要： Novel and useful ribonucleotides of analogs of the well known antibiotics lincomycin and clindamycin. These ribonucleotides are unexpectedly highly active against Streptococcus hemolyticus and Staphylococcus aureus in vivo.
摘要翻译： 新型和有用的核糖核苷酸类似物的众所周知的抗生素林可霉素和克林霉素。 这些核糖核苷酸在体内对溶血链球菌和金黄色葡萄球菌意外高度活跃。
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公开(公告)号：US4335108A
公开(公告)日：1982-06-15
申请号：US180682
申请日：1980-08-25
摘要： Disclosed and claimed is an improved fermentation process for preparing the known antibiotic U-43,120, herein referred to as paulomycin. Also disclosed and claimed are the novel and useful antibiotics paulomycin A and paulomycin B.
摘要翻译： 公开和要求保护的是用于制备已知抗生素U-43,120（在本文中称为保罗霉素）的改进的发酵方法。 还公开并要求保护的是新型有用的抗生素保罗霉素A和保宝霉素B.
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公开(公告)号：US4091201A
公开(公告)日：1978-05-23
申请号：US775857
申请日：1977-03-09
CPC分类号： C07G11/00 , Y10S435/803 , Y10S435/886
摘要： Microbiological process for preparing the known antibiotics, antibiotic A-396-1 and L-dihydrophenylalanine, by use of the new microorganism Streptomyces lemensis, NRRL 8170 using controlled fermentation conditions. These antibiotics are active against Gram-positive and Gram-negative bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.
摘要翻译： 通过使用新的微生物链霉菌Streptomyces lemensis，NRRL 8170使用受控发酵条件制备已知抗生素，抗生素A-396-1和L-二氢苯丙氨酸的微生物过程。 这些抗生素对革兰氏阳性和革兰氏阴性菌有活性。 因此，它们可以用于各种环境中以消除或控制这些细菌。
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公开(公告)号：US4505895A
公开(公告)日：1985-03-19
申请号：US480604
申请日：1983-03-30
CPC分类号： C12P1/06
摘要： Novel and useful antibiotics designated 273a.sub.1.spsb..alpha. and 273a.sub.1.spsb..beta. can be produced in a fermentation using Streptomyces paulus, strain 273, NRRL 12251. These antibiotics are active against various Gram-positive bacteria. Also, these antibiotics are, advantageously, soluble in aqueous solutions.
摘要翻译： 在使用链霉菌（Streptomyces paulus），菌株273，NRRL 12251的发酵中可以产生名为273a1α和273a1β的新型和有用的抗生素。这些抗生素对各种革兰氏阳性细菌具有活性。 而且，这些抗生素有利地可溶于水溶液。
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公开(公告)号：US4430495A
公开(公告)日：1984-02-07
申请号：US419244
申请日：1982-09-17
摘要： Novel and useful ribonucleotides of analogs of the well known antibiotics lincomycin and clindamycin. These ribonucleotides are unexpectedly highly active against Streptococcus hemolyticus and Staphylococcus aureus in vivo. These ribonucleotides are prepared by using resting cell or cell-free extracts of Streptomyces rochei, NRRL 3533, or cell-free extracts of Streptomyces coelicolor, NRRL 3532.
摘要翻译： 新型和有用的核糖核苷酸类似物的众所周知的抗生素林可霉素和克林霉素。 这些核糖核苷酸在体内对溶血链球菌和金黄色葡萄球菌意外高度活跃。 这些核糖核苷酸是通过使用链霉菌（Streptomyces rochei），NRRL 3533的静止细胞或无细胞提取物或无链球菌链霉菌NRRL 3532的提取物来制备的。
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