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1.发明申请Use of LIMK-1, its analogues and ligands for the production of a medicament against a thrombus formation or blood clotting disease 审中-公开使用LIMK-1，其类似物和配体用于生产抗血栓形成或血液凝固疾病的药物公开(公告)号：US20050175601A1
公开(公告)日：2005-08-11
申请号：US10991172
申请日：2004-11-17
CPC分类号： A61K38/45 , G01N33/86 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to LIMK-1, a LIMK-1-analogue or LIMK-1 ligand for the binding to GPIIb and/or activation or inhibition of GPIIb/IIIa downstream signaling, for the production of a medicament for the prevention or treatment of a thrombus formation or blood clotting disease, methods of screening a LIMK-1 analogue or a LIMK-1 ligand and a method for producing a medicament for the treatment of a thrombus formation or blood clotting disease.
摘要翻译： 本发明涉及LIMK-1，用于结合GPIIb的LIMK-1类似物或LIMK-1配体和/或GPIIb / IIIa下游信号传导的活化或抑制，用于生产用于预防或治疗GPIIb / 血栓形成或血液凝固疾病，LIMK-1类似物或LIMK-1配体的筛选方法以及用于治疗血栓形成或血液凝固疾病的药物的制备方法。
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公开(公告)号：US20090149375A1
公开(公告)日：2009-06-11
申请号：US11908467
申请日：2006-03-20
IPC分类号： A61K38/16 , A61K31/7088 , C12Q1/68 , C12Q1/48 , C40B30/00
CPC分类号： A61K38/45
摘要： The present invention refers to the use of the Mst protein or a nucleotide sequence coding for the Mst protein for the treatment of a thromboembolic disorder and to a method of screening a modulator of the Mst protein or the nucleotide sequence coding for the Mst protein.
摘要翻译： 本发明涉及使用Mst蛋白或编码Mst蛋白的核苷酸序列来治疗血栓栓塞性疾病，以及筛选Mst蛋白的调节剂或编码Mst蛋白的核苷酸序列的方法。
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公开(公告)号：US08071297B2
公开(公告)日：2011-12-06
申请号：US12095783
申请日：2006-11-23
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/573 , G01N2333/91215 , G01N2800/32 , G01N2800/52
摘要： The present invention refers to a method for the in vitro or in vivo diagnosis of cardiovascular diseases, in particular high blood pressure, stenosis, vessel occlusion and/or other thrombotic events, wherein the nucleotide at position 950 of a nucleic acid coding for the human ARK2 protein or the amino acid at position 298 of the human ARK2 protein of a sample of a person is determined as well as to the use of ARK2 for the development and/or production of a medicament for treating a cardiovascular disease.
摘要翻译： 本发明涉及体外或体内诊断心血管疾病，特别是高血压，狭窄，血管闭塞和/或其他血栓事件的方法，其中编码人的核酸的位置950处的核苷酸 确定ARK2蛋白或人的样品的人ARK2蛋白的298位的氨基酸以及使用ARK2来开发和/或制备治疗心血管疾病的药物。
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公开(公告)号：US20090239218A1
公开(公告)日：2009-09-24
申请号：US12095783
申请日：2006-11-23
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/573 , G01N2333/91215 , G01N2800/32 , G01N2800/52
摘要： The present invention refers to a method for the in vitro or in vivo diagnosis of cardiovascular diseases, in particular high blood pressure, stenosis, vessel occlusion and/or other thrombotic events, wherein the nucleotide at position 950 of a nucleic acid coding for the human ARK2 protein or the amino acid at position 298 of the human ARK2 protein of a sample of a person is determined as well as to the use of ARK2 for the development and/or production of a medicament for treating a cardiovascular disease.
摘要翻译： 本发明涉及体外或体内诊断心血管疾病，特别是高血压，狭窄，血管闭塞和/或其他血栓事件的方法，其中编码人的核酸的位置950处的核苷酸 确定ARK2蛋白或人的样品的人ARK2蛋白的298位的氨基酸以及使用ARK2来开发和/或制备治疗心血管疾病的药物。
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5.发明授权Imidazopyridazines as PAR1 inhibitors, production thereof, and use as medicaments 有权咪唑并哒嗪作为PAR1抑制剂，其制备及用作药物公开(公告)号：US08598177B2
公开(公告)日：2013-12-03
申请号：US12851198
申请日：2010-08-05
IPC分类号： A61K31/501 , A61K31/50 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, R9, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.
摘要翻译： 本发明涉及新的式I化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，Q1，Q2和Q3各自如下所定义。 式I的化合物具有抗血栓形成活性并特别抑制蛋白酶活化的受体1（PAR1）。 本发明还涉及制备式I化合物及其作为药物的用途的方法。
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公开(公告)号：US20130223023A1
公开(公告)日：2013-08-29
申请号：US13531373
申请日：2012-06-22
IPC分类号： H05K7/02
CPC分类号： B81B7/0029 , B81B2201/0257 , B81B2203/0127 , H01L2224/48091 , H01L2224/48137 , H01L2224/8592 , H01L2924/15151 , H01L2924/16152 , H04R7/18 , H04R19/005 , H04R2307/207 , H01L2924/00014
摘要： A MEMS structure includes a backplate, a membrane, and an adjustable ventilation opening configured to reduce a pressure difference between a first space contacting the membrane and a second space contacting an opposite side of the membrane. The adjustable ventilation opening is passively actuated as a function of the pressure difference between the first space and the second space.
摘要翻译： MEMS结构包括背板，膜和可调节的通风口，其被配置为减小接触膜的第一空间与接触膜的相对侧的第二空间之间的压力差。 根据第一空间和第二空间之间的压差，被调节的通风口被动地致动。
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7.发明授权EGLN2 variants and use thereof in preventing or treating thromboembolic disorders and coronary heart diseases 失效EGLN2变体及其在预防或治疗血栓栓塞性疾病和冠心病中的用途公开(公告)号：US08211427B2
公开(公告)日：2012-07-03
申请号：US13015994
申请日：2011-01-28
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
摘要翻译： 本发明涉及具有丝氨酸或亮氨酸的氨基酸序列58位的人EGLN2变异体及其在预防或治疗血栓栓塞或冠心病，特别是中风，长期可逆性缺血性神经功能缺损（PRIND）， 经皮缺血发作（TIA），心肌梗死和/或早期心肌梗死。
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公开(公告)号：US5631963A
公开(公告)日：1997-05-20
申请号：US331762
申请日：1994-10-31
申请人： Matthias Herrmann
发明人： Matthias Herrmann
CPC分类号： H04B1/1661 , H04B1/1027 , Y10S977/872
摘要： A circuit arrangement for recognizing adjacent channel interference in a stereo radio receiver, in which a stereo multiplex signal is present. An adjacent channel interference signal is obtained as a function of a direct voltage portion of the stereo multiplex signal and as a function of the spectral components of the stereo multiplex signal above 60 kHz.
摘要翻译： 用于识别在其中存在立体声多路复用信号的立体声无线电接收机中的相邻信道干扰的电路装置。 作为立体声多路复用信号的直接电压部分的函数，并且作为高于60kHz的立体声多路复用信号的频谱分量的函数，获得相邻信道干扰信号。
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9.发明授权
公开(公告)号：US5584060A
公开(公告)日：1996-12-10
申请号：US343415
申请日：1995-03-06
申请人： Matthias Herrmann , Lothar Vogt , Juergen Kaesser
发明人： Matthias Herrmann , Lothar Vogt , Juergen Kaesser
CPC分类号： H04B1/1661 , H04B1/1027
摘要： In a circuit arrangement for deriving a signal dependent on the change direction of the incoming signal level in a radio receiver, controllable by a microcomputer, a comparator is provided outside the microcomputer to which a signal representing the respective signal strength and a signal generated by the microcomputer representing the signal strength at an earlier point in time can be supplied. An output signal from the comparator can be supplied to the microcomputer.
摘要翻译： PCT No.PCT / DE94 / 00317 Sec。 371日期：1994年3月6日 102（e）1994年3月6日PCT 1994年3月22日PCT公布。 公开号WO94 / 22226 日期1994年9月29日在用于由微型计算机控制的无线电接收机中取决于输入信号电平的变化方向的信号的电路装置中，在微计算机外部提供比较器，信号表示相应的信号强度和 可以提供由微计算机产生的表示较早时间点的信号强度的信号。 来自比较器的输出信号可以被提供给微型计算机。
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公开(公告)号：US09002037B2
公开(公告)日：2015-04-07
申请号：US13531373
申请日：2012-06-22
申请人： Alfons Dehe , Matthias Herrmann , Ulrich Krumbein , Stefan Barzen , Wolfgang Klein , Wolfgang Friza , Martin Wurzer
发明人： Alfons Dehe , Matthias Herrmann , Ulrich Krumbein , Stefan Barzen , Wolfgang Klein , Wolfgang Friza , Martin Wurzer
CPC分类号： B81B7/0029 , B81B2201/0257 , B81B2203/0127 , H01L2224/48091 , H01L2224/48137 , H01L2224/8592 , H01L2924/15151 , H01L2924/16152 , H04R7/18 , H04R19/005 , H04R2307/207 , H01L2924/00014
摘要： A MEMS structure includes a backplate, a membrane, and an adjustable ventilation opening configured to reduce a pressure difference between a first space contacting the membrane and a second space contacting an opposite side of the membrane. The adjustable ventilation opening is passively actuated as a function of the pressure difference between the first space and the second space.
摘要翻译： MEMS结构包括背板，膜和可调节的通风口，其被配置为减小接触膜的第一空间与接触膜的相对侧的第二空间之间的压力差。 根据第一空间和第二空间之间的压差，被调节的通风口被动地致动。
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