公开(公告)号：US20070271066A1

公开(公告)日：2007-11-22

申请号：US11724738

申请日：2007-03-16

申请人： Alexei Nikitin ,  Mark Frei ,  Naresh Bhavaraju ,  Ivan Osorio ,  Ruslan Davidchack

发明人： Alexei Nikitin ,  Mark Frei ,  Naresh Bhavaraju ,  Ivan Osorio ,  Ruslan Davidchack

IPC分类号： G06F17/18

CPC分类号： G06K9/00536 ,  G06F17/10 ,  G06F17/18 ,  G06F19/24 ,  G16H50/20 ,  G16H50/50

摘要： A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.

摘要翻译： 一种用于实时信号分析的方法，计算机程序和系统，通过跟踪顺序统计滤波器的输出（也称为百分位数，分位数）来提供移动时间窗口中的任意类型信号的时间演化密度和信号特征分布的表征 或等级阶滤波器）。 给定任意类型，原点或尺度的原始输入信号，本发明能够自动量化和检测该信号随时间发生的任何一组可量化特征的分布变化。 此外，本发明快速准确地检测输入信号的某些特征的变化的能力还可以在与未来信号的可能性增加相关联的检测到的变化的情况下进行预测。

公开(公告)号：US20050021313A1

公开(公告)日：2005-01-27

申请号：US10911031

申请日：2004-08-04

申请人： Alexei Nikitin ,  Mark Frei ,  Naresh Bhavaraju ,  Ivan Osorio

发明人： Alexei Nikitin ,  Mark Frei ,  Naresh Bhavaraju ,  Ivan Osorio

IPC分类号： G06F17/18 ,  H03F1/26

CPC分类号： G06K9/00536 ,  G06F17/10 ,  G06F17/18 ,  G06F19/24 ,  G16H50/20 ,  G16H50/50

摘要： A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.

摘要翻译： 一种用于实时信号分析的方法，计算机程序和系统，通过跟踪顺序统计滤波器的输出（也称为百分位数，分位数）来提供移动时间窗口中的任意类型信号的时间演化密度和信号特征分布的表征 或等级阶滤波器）。 给定任意类型，原点或尺度的原始输入信号，本发明能够自动量化和检测该信号随时间发生的任何一组可量化特征的分布变化。 此外，本发明快速准确地检测输入信号的某些特征的变化的能力还可以在与未来信号的可能性增加相关联的检测到的变化的情况下进行预测。

公开(公告)号：US20070272260A1

公开(公告)日：2007-11-29

申请号：US11414736

申请日：2006-04-28

申请人： Alexei Nikitin ,  Ivan Osorio ,  Mark Frei ,  Naresh Bhavaraju

发明人： Alexei Nikitin ,  Ivan Osorio ,  Mark Frei ,  Naresh Bhavaraju

IPC分类号： A61B19/00

CPC分类号： A61N1/0529 ,  A61M5/14276 ,  A61M5/16827 ,  A61M5/16881 ,  A61M2205/054 ,  A61M2205/3507 ,  A61M2210/0693 ,  A61N1/36082

摘要： An implantable interface system for a medical device system providing selective interconnectivity between conduits and therapy elements. The interface system contains connecting elements that each provide a robust connection between a selected conduit and a selected therapy element. The interface system enables the use of a surplus of therapy elements so that treatment to the same site (in the case of electrode migration or failure), or to different sites but within the spatial domain of the interface's elements may be delivered through the spare/excess therapy elements without the need for additional major surgical procedures.

摘要翻译： 一种用于医疗装置系统的可植入界面系统，其提供导管和治疗元件之间的选择性互连。 接口系统包含连接元件，每个连接元件在所选导管和选定的治疗元件之间提供牢固的连接。 接口系统使得能够使用多余的治疗元件，使得可以通过备用/非接触式的治疗单元向相同部位（在电极迁移或失效的情况下）或不同部位但在界面元件的空间域内进行治疗， 多余的治疗元素，而不需要额外的主要外科手术。

公开(公告)号：US20060161384A1

公开(公告)日：2006-07-20

申请号：US11355784

申请日：2006-02-15

申请人： Ivan Osorio ,  Naresh Bhavaraju ,  Thomas Peters ,  Mark Frei ,  Jonathan Werder

发明人： Ivan Osorio ,  Naresh Bhavaraju ,  Thomas Peters ,  Mark Frei ,  Jonathan Werder

IPC分类号： G01R35/00 ,  G04F10/00 ,  G04G15/00

CPC分类号： A61N1/37229 ,  A61B5/0006 ,  A61B5/048 ,  A61B5/4094 ,  A61N1/025 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/37 ,  A61N1/372 ,  G04G7/00 ,  G06F19/00

摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.

公开(公告)号：US20060155495A1

公开(公告)日：2006-07-13

申请号：US11355489

申请日：2006-02-15

申请人： Ivan Osorio ,  Naresh Bhavaraju ,  Thomas Peters ,  Mark Frei ,  Jonathan Werder

发明人： Ivan Osorio ,  Naresh Bhavaraju ,  Thomas Peters ,  Mark Frei ,  Jonathan Werder

IPC分类号： G01R35/00 ,  G01D18/00 ,  G01D21/00

CPC分类号： A61N1/37229 ,  A61B5/0006 ,  A61B5/048 ,  A61B5/4094 ,  A61N1/025 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/37 ,  A61N1/372 ,  G04G7/00 ,  G06F19/00

摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.

公开(公告)号：US20050228461A1

公开(公告)日：2005-10-13

申请号：US11151386

申请日：2005-06-13

申请人： Ivan Osorio ,  Naresh Bhavaraju

发明人： Ivan Osorio ,  Naresh Bhavaraju

IPC分类号： A61B5/0484 ,  A61N1/36 ,  A61N1/18

CPC分类号： A61B5/0484 ,  A61B5/4094 ,  A61N1/36 ,  A61N1/36064 ,  A61N1/36067

摘要： A system for accessing the brain of a subject to record and/or stimulate brain stares thereof. The system includes control means, first accessing means having a plurality of contact surfaces configured to operatively connect the control means to the brain of the subject to provide three-dimensional stimulation thereof; second accessing means having a plurality of contact surfaces to operatively connect the control means to the brain of the subject to provide access thereto for the purposes of obtaining three-dimensional recordings of the brain electrical activity of the subject; and a waveform bank containing a plurality of stimulating waveforms. The control means is configured to operatively apply a first at least one of the stimulating waveforms of the waveform bank to the brain of the subject through the first accessing means and to assess acceptability within defined limits, as determined by preset criteria, of the subject's response to the application of the at first least one of the stimulating waveforms.

摘要翻译： 用于访问受试者脑部以记录和/或刺激其脑神经的系统。 该系统包括控制装置，第一存取装置具有多个接触表面，其被配置为将控制装置可操作地连接到受试者的脑部以提供其三维刺激; 第二存取装置具有多个接触表面，以将控制装置可操作地连接到受试者的大脑以提供对其的访问，以获得对象的脑电活动的三维记录; 以及包含多个刺激波形的波形组。 控制装置被配置为通过第一访问装置将波形组的第一至少一个刺激波形可操作地应用于受试者的大脑，并且通过预设的标准来确定受试者的反应所确定的限定范围内的可接受性 涉及至少一个刺激波形的应用。

公开(公告)号：US20110270346A1

公开(公告)日：2011-11-03

申请号：US12771727

申请日：2010-04-30

申请人： Mark Frei ,  Ivan Osorio

发明人： Mark Frei ,  Ivan Osorio

IPC分类号： A61N1/36

CPC分类号： A61B5/4094 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/0456 ,  A61N1/36053 ,  A61N1/36064 ,  A61N1/36139

摘要： Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test. In one class of beat validity test, a constraint defining a pass is modified at one or more times after the most recent prior valid heart beat that is greater than a constraint modification time threshold

摘要翻译： 用于量化候选心跳的基准时间标记的质量的方法，系统和装置，量化候选心跳的质量或确定患者心脏的搏动序列的时间。 获得候选心跳的基准时间标记。 将所述候选心跳的质量指标设定为第一值。 通过至少一次拍子有效性测试来测试候选心跳。 如果所述候选心跳通过所述至少一个节拍有效性测试，则至少将第二值添加到所述候选心跳的所述质量指标。 使用至少第二次心跳有效性测试来测试候选心跳。 如果所述候选心跳通过所述至少第二次心跳有效性测试，则至少第三值被添加到所述候选心跳的所述质量指标。 在一类节拍有效性测试中，定义通行证的约束在最近的有效心跳之后的一个或多个时间被修改，其大于约束修改时间阈值

公开(公告)号：US20100198098A1

公开(公告)日：2010-08-05

申请号：US12592990

申请日：2009-12-05

申请人： Ivan Osorio ,  Mark Frei ,  David Lerner ,  John Ralston ,  Josef Dorfmeister

发明人： Ivan Osorio ,  Mark Frei ,  David Lerner ,  John Ralston ,  Josef Dorfmeister

IPC分类号： A61B5/0476

CPC分类号： A61B5/048 ,  A61B5/4094 ,  A61B5/7257 ,  A61B5/726 ,  A61N1/08 ,  A61N1/36064 ,  A61N1/36082

摘要： A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.

摘要翻译： 系统（10）在信号处理器（12）中分析表示受试者的大脑活动的信号，用于指示受试者的当前活动状态的信息，以及用于预测活动状态的变化。 一个优选实施例使用非线性滤波方法的组合来执行来自对象患者的电脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成 至少在临床癫痫发作前需要进行分析。 优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

公开(公告)号：US20080064934A1

公开(公告)日：2008-03-13

申请号：US11837987

申请日：2007-08-13

申请人： Mark Frei ,  Ivan Osorio ,  Nina Graves ,  Scott Schaffner ,  Mark Rise ,  Jonathon Giftakis ,  David Carlson

发明人： Mark Frei ,  Ivan Osorio ,  Nina Graves ,  Scott Schaffner ,  Mark Rise ,  Jonathon Giftakis ,  David Carlson

IPC分类号： A61B5/00 ,  A61M5/00 ,  A61N1/36

CPC分类号： A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

公开(公告)号：US20070100278A1

公开(公告)日：2007-05-03

申请号：US11557433

申请日：2006-11-07

申请人： Mark Frei ,  Ivan Osorio

发明人： Mark Frei ,  Ivan Osorio

IPC分类号： A61M31/00 ,  A61B18/18 ,  A61N1/00 ,  A61B5/00 ,  A61B5/04

CPC分类号： A61B5/04012 ,  A61B5/048 ,  A61B5/4094 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7221 ,  A61N1/36014 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N1/3702 ,  A61N1/37229 ,  A61N1/37252

摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.

摘要翻译： 用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。 监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。 该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。 如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。