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公开(公告)号：US06222016B1
公开(公告)日：2001-04-24
申请号：US09351550
申请日：1999-07-12
申请人： Alison Frances Chalker , Maria Magdalena Zalacain Feliu , James Raymond Brown , Alexander Philip Bryant
发明人： Alison Frances Chalker , Maria Magdalena Zalacain Feliu , James Raymond Brown , Alexander Philip Bryant
IPC分类号： C07K100
摘要： The invention provides spoIIIE polypeptides and DNA (RNA) encoding spoIIIE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spoIIIE polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了spoIIIE多肽和编码spoIIIE多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用spoIIIE多肽筛选抗菌化合物的方法。
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公开(公告)号：US5888770A
公开(公告)日：1999-03-30
申请号：US922837
申请日：1997-08-26
申请人： Alison Frances Chalker , Maria Magdalena Zalacain Feliu , James Raymond Brown , Alexander Philip Bryant
发明人： Alison Frances Chalker , Maria Magdalena Zalacain Feliu , James Raymond Brown , Alexander Philip Bryant
IPC分类号： G01N33/53 , A61K31/00 , A61K39/00 , A61K39/085 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P27/00 , A61P31/00 , A61P31/04 , C07K14/31 , C07K14/315 , C07K16/12 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/31 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/569 , G01N33/577 , C07H21/04 , C12N15/63
摘要： The invention provides spoIIIE polypeptides and DNA (RNA) encodig spoIIIE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utlizng spoIIIE polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供spoIIIE多肽和DNA（RNA）编码spoIIIE多肽以及通过重组技术产生此类多肽的方法。 还提供了用于筛选抗菌化合物的spoIIIE多肽的方法。
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公开(公告)号：US06218528B1
公开(公告)日：2001-04-17
申请号：US09078691
申请日：1998-05-14
申请人： Nicola G Wallis , Min Wang , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Alison Frances Chalker , David John Holmes , Karen A Ingraham , Deborah D Jaworski , Jennifer Ray , Lisa K Shilling
发明人： Nicola G Wallis , Min Wang , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Alison Frances Chalker , David John Holmes , Karen A Ingraham , Deborah D Jaworski , Jennifer Ray , Lisa K Shilling
IPC分类号： C07H2104
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C12Y101/01158
摘要： The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了MurB多肽和编码MurB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用MurB多肽筛选抗菌化合物的方法。
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公开(公告)号：US07202071B2
公开(公告)日：2007-04-10
申请号：US10437581
申请日：2003-05-14
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US5883239A
公开(公告)日：1999-03-16
申请号：US896345
申请日：1997-07-18
申请人： James Raymond Brown , Alison Frances Chalker , David John Payne , Lisa Kathleen Shilling , Christopher Michael Traini
发明人： James Raymond Brown , Alison Frances Chalker , David John Payne , Lisa Kathleen Shilling , Christopher Michael Traini
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K16/40 , C12N9/00 , C12N9/10 , C12N15/00 , C12N15/09 , C12N15/54 , C12P21/02 , C12R1/46 , G01N33/566 , G01N33/569 , C07H21/02 , C07H21/04
CPC分类号： C12N9/1092
摘要： The invention provides aroA polypeptides and DNA (RNA) encoding aroA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aroA polypeptides to screen for antibacterial compounds.
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公开(公告)号：US06303771B1
公开(公告)日：2001-10-16
申请号：US09080643
申请日：1998-05-18
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
IPC分类号： C12N1531
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US6160094A
公开(公告)日：2000-12-12
申请号：US226091
申请日：1999-01-05
申请人： James Raymond Brown , Alison Frances Chalker , David John Payne , Lisa Kathleen Shilling , Christopher Michael Traini
发明人： James Raymond Brown , Alison Frances Chalker , David John Payne , Lisa Kathleen Shilling , Christopher Michael Traini
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K16/40 , C12N9/00 , C12N9/10 , C12N15/00 , C12N15/09 , C12N15/54 , C12P21/02 , C12R1/46 , G01N33/566 , G01N33/569 , A61K39/00 , C07K1/00 , C07K14/00
CPC分类号： C12N9/1092
摘要： The invention provides aroA polypeptides and DNA (RNA) encoding aroA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aroA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了aroA多肽和编码aroA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用aroA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06225457B1
公开(公告)日：2001-05-01
申请号：US09305001
申请日：1999-05-04
申请人： Sanjoy Biswas , James Raymond Brown , Martin K R Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin K R Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C07H2104
CPC分类号： C07K14/3156 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The invention provides murF2 polypeptides and polynucleotides encoding murF2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murF2 polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码murF2多肽的murF2多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用murF2多肽筛选抗菌化合物的方法。
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公开(公告)号：US5866369A
公开(公告)日：1999-02-02
申请号：US933115
申请日：1997-09-18
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K38/46 , A61K39/00 , A61K39/09 , A61K48/00 , A61P31/00 , A61P31/04 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N15/00 , C12N15/57 , C12Q1/37 , C12Q1/68 , C12R1/46 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68 , G01N1/20 , G01N15/00 , C01N15/11
CPC分类号： C12N9/48 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ampS polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了ampS多肽和编码amp多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还提供了利用ampS多肽筛选抗菌化合物的方法。
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公开(公告)号：US06228625B1
公开(公告)日：2001-05-08
申请号：US09273686
申请日：1999-03-22
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N900
CPC分类号： C12Q1/6876 , A61K38/00 , C07K14/3156
摘要： The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metK polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了metK多肽和编码metK多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用metK多肽来筛选抗菌化合物的方法。
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