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1.再颁专利Biocompatible crosslinked coating and crosslinkable coating polymer composition for forming such a coating 失效用于形成这种涂层的生物相容性交联涂层和可交联涂层聚合物组合物公开(公告)号：USRE40816E1
公开(公告)日：2009-06-30
申请号：US10946604
申请日：1996-11-01
申请人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe , Lee Rowan
发明人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe , Lee Rowan
IPC分类号： A61F2/06 , C08F230/02
CPC分类号： B21F45/008 , A61F2/0077 , A61F2/90 , A61F2/95 , A61F2/966 , A61F2002/9665 , A61F2210/0019 , A61F2220/0058 , A61F2220/0075 , B21F45/00
摘要： A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle α between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device. The present invention provides a biocompatible crosslinked coating and a crosslinkable coating polymer composition for forming such a coating. The biocompatible crosslinked coating may be formed by curing a polymer of 23 mole % (methacryloyloxy ethyl)-2-(trimethylammonium ethyl) phosphate inner salt, 47 mole % lauryl methacrylate, 5 mole % γtrimethoxysilyl propyl methacrylate and 25 mole % of hydroxy propyl methacrylate. The crosslinkable coating polymer may include 23 mole % (methacryloyloxy ethyl)-2-(trimethylammonium ethyl) phosphate inner salt, 47 mole % lauryl methacrylate, 5 mole % γtrimethoxysilyl propyl methacrylate and 25 mole % of hydroxy propyl methacrylate.
摘要翻译： <？delete-start id =“DEL-S-00001”date =“20090630”？>用于体腔内腔内植入的编织支架（1）是自膨胀的，并具有径向扩张构型，其中细丝之间的角度α 是急性的 一些或全部细丝（6,7）在支架的每个端部（4,5）处成对地焊接在一起，以提供珠（8），从而加强支架并帮助其从输送装置展开。 支架优选使用生物相容性聚合物涂层完全涂覆，所述聚合物优选具有侧链磷酰胆碱基团。 描述通过编织和焊接制造支架的方法以及用于部署装置的递送装置。<？delete-end id =“DEL-S-00001”？> <？insert-start id =“INS-S -00001“date =”20090630“？本发明提供一种用于形成这种涂层的生物相容性交联涂层和可交联涂层聚合物组合物。 生物相容的交联涂层可以通过固化23摩尔％（甲基丙烯酰氧基乙基）-2-（三甲基铵乙基）磷酸盐内盐，47摩尔％甲基丙烯酸月桂酯，5摩尔％甲基丙烯酸氨基三甲氧基甲硅烷基丙酯和25摩尔％甲基丙烯酸羟丙酯 。 可交联涂料聚合物可以包括23摩尔％（甲基丙烯酰氧基乙基）-2-（三甲基铵乙基）磷酸盐内盐，47摩尔％甲基丙烯酸月桂酯，5摩尔％甲基丙烯酸氨基三甲氧基甲硅烷基丙酯和25摩尔％甲基丙烯酸羟丙酯。 id =“INS-S-00001”？>
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公开(公告)号：US6083257A
公开(公告)日：2000-07-04
申请号：US11523
申请日：1998-04-28
申请人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe
发明人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe
CPC分类号： B21F45/008 , A61F2/90 , A61F2/95 , A61F2/966 , B21F45/00 , A61F2/0077 , A61F2002/9665 , A61F2210/0019 , A61F2220/0058 , A61F2220/0075
摘要： A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle .alpha. between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device.
摘要翻译： PCT No.PCT / GB96 / 02689 Sec。 371日期：1998年4月28日 102（e）日期1998年4月28日PCT 1996年11月1日PCT PCT。 公开号WO97 / 16133 日期1997年5月9日用于体腔内腔内植入的编织支架（1）是自膨胀的，并且具有径向扩张构型，其中细丝之间的角度α是尖锐的。 一些或全部细丝（6,7）在支架的每个端部（4,5）处成对地焊接在一起，以提供珠（8），从而加强支架并帮助其从输送装置展开。 支架优选使用生物相容性聚合物涂层完全涂覆，所述聚合物优选具有侧链磷酰胆碱基团。 描述通过编织和焊接制造支架的方法以及用于展开装置的输送装置。
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公开(公告)号：US07754272B2
公开(公告)日：2010-07-13
申请号：US10842416
申请日：2004-05-11
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , C08L33/14
摘要： An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethyl-phosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
摘要翻译： 具有包含聚合物基质的涂层的植入物在药物溶液中溶胀，由此将药物活性化合物吸入聚合物基质中。 当植入产物时，发生药物活性化合物从涂层的释放。 聚合物优选由包含两性离子单体，最优选2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸内酯的烯属不饱和单体形成。 形成聚合物的单体可以进一步包括表面结合单体，例如含疏水基团的单体和可交联单体，其含量可用于控制溶胀性。 优选地，植入物是支架，并且外壁表面上的聚合物涂层比内表面上的聚合物涂层更厚。 可以通过选择共聚单体来控制药物的释放。 植入物适合用于心血管系统中的支架。
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公开(公告)号：US06872225B1
公开(公告)日：2005-03-29
申请号：US09979602
申请日：2000-05-30
IPC分类号： A61F2/84 , A61K9/00 , A61K9/28 , A61L27/28 , A61L27/34 , A61L27/54 , A61L31/00 , A61L31/08 , A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , C08L33/14
摘要： An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethylphosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
摘要翻译： 具有包含聚合物基质的涂层的植入物在药物溶液中溶胀，由此将药物活性化合物吸入聚合物基质中。 当植入产物时，发生药物活性化合物从涂层的释放。 聚合物优选由包含两性离子单体，最优选2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸酯内盐的烯属不饱和单体形成。 形成聚合物的单体可以进一步包括表面结合单体，例如含疏水基团的单体和可交联单体，其含量可用于控制溶胀性。 优选地，植入物是支架，并且外壁表面上的聚合物涂层比内表面上的聚合物涂层更厚。 可以通过选择共聚单体来控制药物的释放。 植入物适合用于心血管系统中的支架。
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公开(公告)号：US07794775B2
公开(公告)日：2010-09-14
申请号：US11274158
申请日：2005-11-16
申请人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
发明人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
CPC分类号： A61L29/085 , A61L31/10
摘要： The present invention relate to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stent on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group. Preferably the coated product is contacted with ethylene oxide to provide simultaneous sterilization and additional curing.
摘要翻译： 本发明涉及一种安装在球囊导管上的球囊可扩张支架，整个组件被涂覆有凝聚聚合物涂层，其优选地基本上在圆周上基本上连续，更优选地，支架在气囊上的轴向长度。 聚合物涂层改善了支架在输送过程中在气囊上的保持性，并且不会对展开特征以及球囊破坏特性产生不利影响。 该产品通过将支架安装在气球上并用包含合适聚合物的液体涂料组合物涂覆组合物，然后固化涂层而制成。 聚合物是生物相容的并且优选在涂料组合物中可交联，并在最终产物中交联。 合适的聚合物由包括两性离子，优选磷酰胆碱的单体和包含三烷氧基甲硅烷基的单体形成。 优选地，涂覆的产品与环氧乙烷接触以提供同时的灭菌和额外的固化。
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公开(公告)号：US07306625B1
公开(公告)日：2007-12-11
申请号：US10018783
申请日：2000-06-26
申请人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
发明人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61L31/10
摘要： The present invention relates to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stent on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group. Preferably the coated product is contacted with ethylene oxide to provide simultaneous sterilization and additional curing.
摘要翻译： 本发明涉及一种安装在气囊导管上的球囊可扩张支架，整个组件被涂覆有凝聚聚合物涂层，其优选地基本上在圆周上是连续的，更优选地，支架在气囊上的轴向长度。 聚合物涂层改善了支架在输送过程中在气囊上的保持性，并且不会对展开特征以及球囊破坏特性产生不利影响。 该产品通过将支架安装在气球上并用包含合适聚合物的液体涂料组合物涂覆组合物，然后固化涂层而制成。 聚合物是生物相容的并且优选在涂料组合物中可交联，并在最终产物中交联。 合适的聚合物由包括两性离子，优选磷酰胆碱的单体和包含三烷氧基甲硅烷基的单体形成。 优选地，涂覆的产品与环氧乙烷接触以提供同时的灭菌和额外的固化。
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公开(公告)号：US08052746B2
公开(公告)日：2011-11-08
申请号：US11781670
申请日：2007-07-23
申请人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
发明人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61L31/10
摘要： The present invention relates to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stem on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group. Preferably the coated product is contacted with ethylene oxide to provide simultaneous sterilization and additional curing.
摘要翻译： 本发明涉及一种安装在球囊导管上的球囊可扩张支架，整个组件用一层粘合聚合物涂层进行涂覆，该涂层优选在圆周上基本上连续，并且更优选地在气囊上的杆的轴向长度。 聚合物涂层改善了支架在输送过程中在气囊上的保持性，并且不会对展开特征以及球囊破坏特性产生不利影响。 该产品通过将支架安装在气球上并用包含合适聚合物的液体涂料组合物涂覆组合物，然后固化涂层而制成。 聚合物是生物相容的并且优选在涂料组合物中可交联，并在最终产物中交联。 合适的聚合物由包括两性离子，优选磷酰胆碱的单体和包含三烷氧基甲硅烷基的单体形成。 优选地，涂覆的产品与环氧乙烷接触以提供同时的灭菌和额外的固化。
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公开(公告)号：US5851430A
公开(公告)日：1998-12-22
申请号：US844318
申请日：1997-04-18
CPC分类号： B01J13/00 , C08L95/005 , Y10S516/922 , Y10S516/923
摘要： An HIPR emulsion of bitumen in water is prepared by a method which comprises directly mixing 70 to 98% by volume of bitumen having a viscosity in the range 200 to 500,000 mPa.s at the mixing temperature with 30 to 2% by volume of an aqueous solution of an emulsifying surfactant, percentages being expressed as percentages by volume of the total mixture. Mixing is effected under low shear conditions in the range 10 to 1,000 reciprocal seconds in such manner that an emulsion is formed comprising highly distorted bitumen droplets having mean droplet diameters in the range 2 to 50 micron separated by thin films of water. The emulsions can be cut back to provide stable emulsions of lower bitumen content which are useful in roadmaking and the formation of protective coatings.
摘要翻译： 通过一种方法制备沥青在水中的HIPR乳液，该方法包括在混合温度下将70至98体积％的具有200至500,000mPa.s的粘度的沥青与30至2体积％的水溶液 乳化表面活性剂的溶液，百分比表示为总混合物的体积百分比。 在低剪切条件下在10至1000个倒数秒的范围内进行混合，使得形成包含高度变形的沥青液滴的乳液，其具有由薄膜水分离的2至50微米的平均液滴直径。 乳液可以被切割以提供可用于道路修复和形成保护性涂层的较低沥青含量的稳定乳液。
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公开(公告)号：US06497916B1
公开(公告)日：2002-12-24
申请号：US09693837
申请日：2000-10-23
IPC分类号： A61L2700
CPC分类号： B05D1/18 , B05C3/09 , B05C9/12 , B05D7/222 , Y10S118/12
摘要： An apparatus for coating tubular members, such as stents comprises a liquid reservoir and a stent support member for supporting, in use, a tubular member. Support member dipping means places the support member in the liquid reservoir in use and draws the support member therefrom. Pressure differential generating means generates a pressure differential. The stent support member is arranged to provide a central passageway through a stent placed thereon, the central passageway having a plurality of perforations formed therein, and the pressure differential generating means is arranged to generate, in use, a pressure differential between the passageway and the tubular member.
摘要翻译： 用于涂覆管状构件（例如支架）的装置包括液体储存器和用于在使用中支撑管状构件的支架支撑构件。 支撑构件浸渍装置将支撑构件放置在使用中的液体储存器中并从其中抽出支撑构件。 压力差产生装置产生压力差。 所述支架支撑构件被布置成提供通过其上放置的支架的中心通道，所述中心通道具有形成在其中的多个穿孔，并且所述压力差产生装置布置成在使用中产生所述通道和所述通道之间的压力差 管状构件。
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公开(公告)号：US5641433A
公开(公告)日：1997-06-24
申请号：US476495
申请日：1995-06-07
CPC分类号： B01J13/00 , F17D1/17 , Y10T137/0391
摘要： An HIPR (high internal phase ratio) emulsion of oil in water is prepared by directly mixing 70 to 98% by volume of a viscous oil having a viscosity in the range 200 to 250,000 mPa.s at the mixing temperature with 30 to 2% by volume of an aqueous solution of an emulsifying surfactant or an alkali, percentages being expressed as percentages by volume of the total mixture. Mixing is effected under low shear conditions in the range 10 to 1,000 reciprocal seconds in such manner that an emulsion is formed comprising highly distorted oil droplets having mean droplet diameters in the range 2 to 50 micron separated by thin interfacial films. The emulsions are much less viscous than the oils from which they are prepared and may, optionally after dilution, be pumped through a pipeline.
摘要翻译： 油中水的HIPR（高内相比）乳液通过将70至98体积％的粘度油在粘度为200至250,000mPa.s的混合温度下以30至2％ 乳化表面活性剂或碱的水溶液的体积，百分比表示为总混合物的体积百分比。 在低剪切条件下在10至1000个倒数秒的范围内进行混合，使得形成包含由薄界面膜分离的平均液滴直径在2至50微米范围内的高度变形油滴的乳液。 乳液比它们制备的油粘度低得多，并且可以任选地在稀释后被泵送通过管道。
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