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1.再颁专利Biocompatible crosslinked coating and crosslinkable coating polymer composition for forming such a coating 失效用于形成这种涂层的生物相容性交联涂层和可交联涂层聚合物组合物公开(公告)号：USRE40816E1
公开(公告)日：2009-06-30
申请号：US10946604
申请日：1996-11-01
申请人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe , Lee Rowan
发明人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe , Lee Rowan
IPC分类号： A61F2/06 , C08F230/02
CPC分类号： B21F45/008 , A61F2/0077 , A61F2/90 , A61F2/95 , A61F2/966 , A61F2002/9665 , A61F2210/0019 , A61F2220/0058 , A61F2220/0075 , B21F45/00
摘要： A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle α between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device. The present invention provides a biocompatible crosslinked coating and a crosslinkable coating polymer composition for forming such a coating. The biocompatible crosslinked coating may be formed by curing a polymer of 23 mole % (methacryloyloxy ethyl)-2-(trimethylammonium ethyl) phosphate inner salt, 47 mole % lauryl methacrylate, 5 mole % γtrimethoxysilyl propyl methacrylate and 25 mole % of hydroxy propyl methacrylate. The crosslinkable coating polymer may include 23 mole % (methacryloyloxy ethyl)-2-(trimethylammonium ethyl) phosphate inner salt, 47 mole % lauryl methacrylate, 5 mole % γtrimethoxysilyl propyl methacrylate and 25 mole % of hydroxy propyl methacrylate.
摘要翻译： <？delete-start id =“DEL-S-00001”date =“20090630”？>用于体腔内腔内植入的编织支架（1）是自膨胀的，并具有径向扩张构型，其中细丝之间的角度α 是急性的 一些或全部细丝（6,7）在支架的每个端部（4,5）处成对地焊接在一起，以提供珠（8），从而加强支架并帮助其从输送装置展开。 支架优选使用生物相容性聚合物涂层完全涂覆，所述聚合物优选具有侧链磷酰胆碱基团。 描述通过编织和焊接制造支架的方法以及用于部署装置的递送装置。<？delete-end id =“DEL-S-00001”？> <？insert-start id =“INS-S -00001“date =”20090630“？本发明提供一种用于形成这种涂层的生物相容性交联涂层和可交联涂层聚合物组合物。 生物相容的交联涂层可以通过固化23摩尔％（甲基丙烯酰氧基乙基）-2-（三甲基铵乙基）磷酸盐内盐，47摩尔％甲基丙烯酸月桂酯，5摩尔％甲基丙烯酸氨基三甲氧基甲硅烷基丙酯和25摩尔％甲基丙烯酸羟丙酯 。 可交联涂料聚合物可以包括23摩尔％（甲基丙烯酰氧基乙基）-2-（三甲基铵乙基）磷酸盐内盐，47摩尔％甲基丙烯酸月桂酯，5摩尔％甲基丙烯酸氨基三甲氧基甲硅烷基丙酯和25摩尔％甲基丙烯酸羟丙酯。 id =“INS-S-00001”？>
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公开(公告)号：US6083257A
公开(公告)日：2000-07-04
申请号：US11523
申请日：1998-04-28
申请人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe
发明人： Alistair Stewart Taylor , Peter William Stratford , Yiannakis Petrou Yianni , Matthew John Woodroffe
CPC分类号： B21F45/008 , A61F2/90 , A61F2/95 , A61F2/966 , B21F45/00 , A61F2/0077 , A61F2002/9665 , A61F2210/0019 , A61F2220/0058 , A61F2220/0075
摘要： A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle .alpha. between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device.
摘要翻译： PCT No.PCT / GB96 / 02689 Sec。 371日期：1998年4月28日 102（e）日期1998年4月28日PCT 1996年11月1日PCT PCT。 公开号WO97 / 16133 日期1997年5月9日用于体腔内腔内植入的编织支架（1）是自膨胀的，并且具有径向扩张构型，其中细丝之间的角度α是尖锐的。 一些或全部细丝（6,7）在支架的每个端部（4,5）处成对地焊接在一起，以提供珠（8），从而加强支架并帮助其从输送装置展开。 支架优选使用生物相容性聚合物涂层完全涂覆，所述聚合物优选具有侧链磷酰胆碱基团。 描述通过编织和焊接制造支架的方法以及用于展开装置的输送装置。
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公开(公告)号：US07754272B2
公开(公告)日：2010-07-13
申请号：US10842416
申请日：2004-05-11
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , C08L33/14
摘要： An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethyl-phosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
摘要翻译： 具有包含聚合物基质的涂层的植入物在药物溶液中溶胀，由此将药物活性化合物吸入聚合物基质中。 当植入产物时，发生药物活性化合物从涂层的释放。 聚合物优选由包含两性离子单体，最优选2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸内酯的烯属不饱和单体形成。 形成聚合物的单体可以进一步包括表面结合单体，例如含疏水基团的单体和可交联单体，其含量可用于控制溶胀性。 优选地，植入物是支架，并且外壁表面上的聚合物涂层比内表面上的聚合物涂层更厚。 可以通过选择共聚单体来控制药物的释放。 植入物适合用于心血管系统中的支架。
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公开(公告)号：US06872225B1
公开(公告)日：2005-03-29
申请号：US09979602
申请日：2000-05-30
IPC分类号： A61F2/84 , A61K9/00 , A61K9/28 , A61L27/28 , A61L27/34 , A61L27/54 , A61L31/00 , A61L31/08 , A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/02 , C08L33/14
摘要： An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethylphosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
摘要翻译： 具有包含聚合物基质的涂层的植入物在药物溶液中溶胀，由此将药物活性化合物吸入聚合物基质中。 当植入产物时，发生药物活性化合物从涂层的释放。 聚合物优选由包含两性离子单体，最优选2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸酯内盐的烯属不饱和单体形成。 形成聚合物的单体可以进一步包括表面结合单体，例如含疏水基团的单体和可交联单体，其含量可用于控制溶胀性。 优选地，植入物是支架，并且外壁表面上的聚合物涂层比内表面上的聚合物涂层更厚。 可以通过选择共聚单体来控制药物的释放。 植入物适合用于心血管系统中的支架。
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公开(公告)号：US07794775B2
公开(公告)日：2010-09-14
申请号：US11274158
申请日：2005-11-16
申请人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
发明人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
CPC分类号： A61L29/085 , A61L31/10
摘要： The present invention relate to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stent on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group. Preferably the coated product is contacted with ethylene oxide to provide simultaneous sterilization and additional curing.
摘要翻译： 本发明涉及一种安装在球囊导管上的球囊可扩张支架，整个组件被涂覆有凝聚聚合物涂层，其优选地基本上在圆周上基本上连续，更优选地，支架在气囊上的轴向长度。 聚合物涂层改善了支架在输送过程中在气囊上的保持性，并且不会对展开特征以及球囊破坏特性产生不利影响。 该产品通过将支架安装在气球上并用包含合适聚合物的液体涂料组合物涂覆组合物，然后固化涂层而制成。 聚合物是生物相容的并且优选在涂料组合物中可交联，并在最终产物中交联。 合适的聚合物由包括两性离子，优选磷酰胆碱的单体和包含三烷氧基甲硅烷基的单体形成。 优选地，涂覆的产品与环氧乙烷接触以提供同时的灭菌和额外的固化。
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公开(公告)号：US07306625B1
公开(公告)日：2007-12-11
申请号：US10018783
申请日：2000-06-26
申请人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
发明人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61L31/10
摘要： The present invention relates to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stent on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group. Preferably the coated product is contacted with ethylene oxide to provide simultaneous sterilization and additional curing.
摘要翻译： 本发明涉及一种安装在气囊导管上的球囊可扩张支架，整个组件被涂覆有凝聚聚合物涂层，其优选地基本上在圆周上是连续的，更优选地，支架在气囊上的轴向长度。 聚合物涂层改善了支架在输送过程中在气囊上的保持性，并且不会对展开特征以及球囊破坏特性产生不利影响。 该产品通过将支架安装在气球上并用包含合适聚合物的液体涂料组合物涂覆组合物，然后固化涂层而制成。 聚合物是生物相容的并且优选在涂料组合物中可交联，并在最终产物中交联。 合适的聚合物由包括两性离子，优选磷酰胆碱的单体和包含三烷氧基甲硅烷基的单体形成。 优选地，涂覆的产品与环氧乙烷接触以提供同时的灭菌和额外的固化。
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公开(公告)号：US08052746B2
公开(公告)日：2011-11-08
申请号：US11781670
申请日：2007-07-23
申请人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
发明人： Peter William Stratford , Alistair Stewart Taylor , Vincent James O'Byrne , John Tom Clarke , Denis Dominic Healy
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61L31/10
摘要： The present invention relates to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stem on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group. Preferably the coated product is contacted with ethylene oxide to provide simultaneous sterilization and additional curing.
摘要翻译： 本发明涉及一种安装在球囊导管上的球囊可扩张支架，整个组件用一层粘合聚合物涂层进行涂覆，该涂层优选在圆周上基本上连续，并且更优选地在气囊上的杆的轴向长度。 聚合物涂层改善了支架在输送过程中在气囊上的保持性，并且不会对展开特征以及球囊破坏特性产生不利影响。 该产品通过将支架安装在气球上并用包含合适聚合物的液体涂料组合物涂覆组合物，然后固化涂层而制成。 聚合物是生物相容的并且优选在涂料组合物中可交联，并在最终产物中交联。 合适的聚合物由包括两性离子，优选磷酰胆碱的单体和包含三烷氧基甲硅烷基的单体形成。 优选地，涂覆的产品与环氧乙烷接触以提供同时的灭菌和额外的固化。
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公开(公告)号：US20110151013A1
公开(公告)日：2011-06-23
申请号：US12991321
申请日：2009-05-14
IPC分类号： A61K9/51 , A61K9/00 , C12N5/071 , A61K31/7105 , B82Y5/00
CPC分类号： A61K9/1273 , A61K9/0019 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要： The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
摘要翻译： 本发明提供包含囊泡并包封在囊泡内的组合物，其包含小于1000个核苷酸的核酸，其中囊泡包含具有亲水和疏水嵌段的两亲嵌段共聚物。 还提供了形成囊泡的方法和将核酸，特别是将iRNA递送到细胞中的方法。
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9.发明授权Anionic-cationic polyion complexes comprising zwitterionic monomer component 有权包含两性离子单体组分的阴离子阳离子聚阳离子络合物公开(公告)号：US06524569B1
公开(公告)日：2003-02-25
申请号：US09831753
申请日：2001-05-14
IPC分类号： A61K3174
CPC分类号： C08K9/12 , C08L57/04 , C08L57/12 , C08L2666/04
摘要： A polyion complex (PIC) is formed of an anionic soluble polymer formed from ethylenically unsaturated monomers including at least one anionic or monomer and a cationic soluble polymer formed from ethylenically unsaturated monomer including at least one cationic monomer, in which the monomers used to form at least one of the polymers comprise a zwitterionic monomer and in which the monomers used to form at least one of the polymers include non-ionic monomer, preferably C1-24 alkyl(meth)acrylate, in which the overall ratio of anionic groups to cationic groups in the PIC is in the range 1.5:1 to 1:1.5, and in which the polymers are combined in ratios to provide a PIC in which there are units derived from zwitterionic monomer in an amount in the range 1 to 70 mole % based on total monomer derived units in the PIC and there are units derived from non-ionic monomer in an amount in the range 0 to 60 mole % based on total monomer derived units in the PIC. The PIC is preferably swollen in water and is a flowable gel. The zwitterionic monomer is preferably 2-(methacyloyloxyethyl)-2′-(trimethylammoniumethyl)phosphate inner salt.
摘要翻译： 聚阴离子络合物（PIC）由阴离子可溶性聚合物形成，其由包含至少一种阴离子或单体的烯属不饱和单体和由包含至少一种阳离子单体的烯属不饱和单体形成的阳离子可溶性聚合物形成，其中用于在 至少一种聚合物包含两性离子单体，其中用于形成至少一种聚合物的单体包括非离子单体，优选C 1-4烷基（甲基）丙烯酸酯，其中阴离子基团与阳离子基团的总比例 在PIC中的范围为1.5:1至1:1.5，其中聚合物的比例组合以提供PIC，其中存在衍生自两性离子单体的单元，其量为1至70摩尔％，基于 PIC中的单体衍生单元总数，并且源自非离子单体的单元的量为基于PIC中单体衍生单元的0至60摩尔％。 PIC优选在水中溶胀并且是可流动的凝胶。 两性离子单体优选为2-（甲基氰基乙氧基乙基）-2' - （三甲基铵乙基）磷酸酯内盐。
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公开(公告)号：US08455003B2
公开(公告)日：2013-06-04
申请号：US13452337
申请日：2012-04-20
申请人： Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
发明人： Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
CPC分类号： A61K31/704 , A61J3/00 , A61K9/00 , A61K9/146 , A61K9/1635 , A61K49/00
摘要： A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译： 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒，并在其中吸收蒽环类。 适合地，聚合物是基于聚（乙烯醇）的聚合物，并且药物是多柔比星。
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