Complex miRNA Sets as Novel Biomarkers for an Acute Coronary Syndrome
    6.
    发明申请
    Complex miRNA Sets as Novel Biomarkers for an Acute Coronary Syndrome 有权
    复杂miRNA作为急性冠脉综合征的新型生物标志物

    公开(公告)号:US20130157883A1

    公开(公告)日:2013-06-20

    申请号:US13642321

    申请日:2011-04-19

    IPC分类号: C12Q1/68

    摘要: The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of an acute coronary syndrome in a blood sample from a human. Further, the present invention relates to means for diagnosing and/or prognosing of an acute coronary syndrome comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of an acute coronary syndrome based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome compared to a reference. In addition, the present invention relates to a kit for diagnosing and/or prognosing of an acute coronary syndrome comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome and at least one reference.

    摘要翻译: 本发明涉及用于检测来自人的血液样品中用于诊断和/或预测急性冠状动脉综合征的单miRNA或多组miRNA的多核苷酸或多组核苷酸。 此外,本发明涉及用于诊断和/或预测包含所述多核苷酸或多组核苷酸的急性冠状动脉综合征的方法。 此外,本发明涉及一种用于诊断和/或预测急性冠状动脉综合征的方法,所述方法基于与参考文献相比较来确定代表急性冠状动脉综合征的单个miRNA或miRNA集合的表达谱。 此外,本发明涉及一种用于诊断和/或预后的急性冠状动脉综合征的试剂盒,其包括用于确定代表急性冠状动脉综合征的单个miRNA或miRNA集合的表达谱的方法和至少一个参考文献。