公开(公告)号：US20110196170A1

公开(公告)日：2011-08-11

申请号：US13021173

申请日：2011-02-04

申请人： HANSGEORG ERNST ,  Walter Dobler ,  Andreas Keller ,  Klaus Henrich

发明人： HANSGEORG ERNST ,  Walter Dobler ,  Andreas Keller ,  Klaus Henrich

IPC分类号： C07C67/14

CPC分类号： C07C403/24 ,  C07C2601/16

摘要： The present invention relates to an improved method for producing all-E astaxanthin dimethyldisuccinate of the formula I.

摘要翻译： 本发明涉及一种制备式I的全-E虾青素二甲基丁二酸酯的改进方法。

公开(公告)号：US08492579B2

公开(公告)日：2013-07-23

申请号：US13021173

申请日：2011-02-04

申请人： Hansgeorg Ernst ,  Walter Dobler ,  Andreas Keller ,  Klaus Henrich

发明人： Hansgeorg Ernst ,  Walter Dobler ,  Andreas Keller ,  Klaus Henrich

IPC分类号： C07C403/24

CPC分类号： C07C403/24 ,  C07C2601/16

摘要： The present invention relates to an improved method for producing all-E astaxanthin dimethyldisuccinate of the formula I.

摘要翻译： 本发明涉及一种生产式I的全-E虾青素二甲基丁二酸酯的改进方法。

公开(公告)号：US4778531A

公开(公告)日：1988-10-18

申请号：US68171

申请日：1987-06-30

申请人： Walter Dobler ,  Hansgeorg Ernst ,  Joachim Paust

发明人： Walter Dobler ,  Hansgeorg Ernst ,  Joachim Paust

IPC分类号： C07B61/00 ,  C07H3/00 ,  C07H3/02 ,  C07H1/00 ,  C13J1/06

CPC分类号： C07H3/02

摘要： Pentoses and hexoses are epimerized by heating sugar dissolved in a solvent in the presence of a molybdenum(VI) compound, by an improved process in which, for the preparation of a sugar having cis OH groups in the 2- or 3-position, of the formula Ia or Ib ##STR1## where R is one of the radicals ##STR2## a homogeneous solution of the corresponding sugar of the formula IIa or IIb ##STR3## is heated to 75.degree.-100.degree. C. in the presence of from 30 to 200 mol %, based on sugar used, of a metal salt of the formula (III)MeX.sub.2 (III)where Me is Mg, Ca, Sr, Ba or Zn and X is Cl or Br, which may or may not contain water of crystallization, and in the presence of from 2 to 20 mol %, based on the sugar used, of a molybdenum(VI) compound.The process is particularly important for the preparation of D-ribose, which is required as an intermediate for vitamin B.sub.2.

摘要翻译： 戊糖和己糖通过加热溶解在钼（VI）化合物存在下的溶剂中的糖进行差向异构化，其中通过改进方法，其中为了制备在2-或3-位具有顺式OH基团的糖， 式Ia或Ib的化合物，其中R是式IIa或IIb的相应糖的均匀溶液之一的基团之一，在30℃的存在下加热至75℃-100℃ （III）的MeX2（III）的金属盐，其中Me是Mg，Ca，Sr，Ba或Zn，X是Cl或Br，其可以含有或可以不含水 的结晶，并且在基于所用糖的2至20摩尔％的存在下，使用钼（VI）化合物。 该方法对于制备作为维生素B2的中间体的D-核糖是特别重要的。

公开(公告)号：US5773635A

公开(公告)日：1998-06-30

申请号：US498840

申请日：1995-07-06

申请人： Walter Dobler ,  Wolfgang Krause ,  Joachim Paust ,  Otto Worz ,  Udo Rheude ,  Wolfram Burst ,  Gunter Dauwel ,  Armin Bertram ,  Bernhard Schulz ,  Gunter Wegner ,  Peter Munster ,  Hansgeorg Ernst ,  Arno Kochner ,  Heinz Etzrodt

发明人： Walter Dobler ,  Wolfgang Krause ,  Joachim Paust ,  Otto Worz ,  Udo Rheude ,  Wolfram Burst ,  Gunter Dauwel ,  Armin Bertram ,  Bernhard Schulz ,  Gunter Wegner ,  Peter Munster ,  Hansgeorg Ernst ,  Arno Kochner ,  Heinz Etzrodt

IPC分类号： C07C51/16 ,  C07C403/00 ,  C07C403/20

CPC分类号： C07C403/20 ,  C07C403/16 ,  C07B2200/09 ,  C07C2101/16

摘要： A process for preparing polyenecarbonyl compounds having a high all-E content and their acetals or ketals by aldol condensation or Horner-Emmons reaction comprises carrying out the reaction, for the purposes of the preferred formation of a double bond of E configuration and in order to maintain the E configuration of the double bonds in the stating compounds as completely as possible, in the presence of oxygen or an oxygen-inert gas mixture or nitric oxide or a nitric oxide-inert gas mixture and/or in the presence of specific stable radicals and/or in the presence of quinones or quinone derivatives.

摘要翻译： 通过醛醇缩合或霍纳 - 埃蒙斯反应制备具有高全E含量的多元羰基化合物及其缩醛或缩酮的方法包括进行反应，为了优选形成E构型的双键，为了 在氧气或氧惰性气体混合物或一氧化氮或一氧化氮惰性气体混合物的存在下和/或在特定的稳定基团的存在下，尽可能地完全地保持化合物中双键的E构型 和/或在醌或醌衍生物的存在下。

公开(公告)号：US5625099A

公开(公告)日：1997-04-29

申请号：US471314

申请日：1995-05-23

申请人： Hansgeorg Ernst ,  Walter Dobler ,  Joachim Paust ,  Udo Rheude

发明人： Hansgeorg Ernst ,  Walter Dobler ,  Joachim Paust ,  Udo Rheude

IPC分类号： C07C41/18 ,  C07C45/45 ,  C07C49/303 ,  C07C403/24 ,  C07D317/46 ,  C07D317/50 ,  C07D317/54 ,  C07D407/06 ,  C07D407/12 ,  C07F9/54 ,  C09B23/10

CPC分类号： C07C403/24 ,  C07C403/04 ,  C07C403/08 ,  C07C403/10 ,  C07D317/46 ,  C07F9/5435 ,  C07F9/5442 ,  C07C2101/16 ,  Y02P20/55

摘要： Abstract of the Disclosure: Compounds of the formula I ##STR1## where R.sup.1 is H or C.sub.1 -C.sub.4 -alkyl, R.sup.2 is C.sub.1 -C.sub.4 -alkyl and R.sup.3 is an ether, silyl ether or acetal protective group which can be converted into a hydroxyl group by hydrolysis, in particular one of the radicals ##STR2## and a process for preparing these compounds by reacting an alkenyne of the formula II ##STR3## in an inert solvent in the presence of lithium amide with a cyclohexenone of the formula III ##STR4## and the use of the compounds of the formula I for preparing astaxanthin, are described.

摘要翻译： 本发明摘要：式Ⅰ化合物其中R 1为H或C 1 -C 4烷基，R 2为C 1 -C 4烷基，R 3为醚，可转化的甲硅烷基醚或缩醛保护基 通过水解形成羟基，特别是一个基团，以及通过在惰性溶剂中在酰胺与环己烯酮的存在下使式II的烯键（II）反应来制备这些化合物的方法 描述了式III（III）化合物和式I化合物用于制备虾青素的用途。

公开(公告)号：US5717128A

公开(公告)日：1998-02-10

申请号：US535637

申请日：1995-09-28

申请人： Wolfgang Krause ,  Hansgeorg Ernst ,  Joachim Paust ,  Udo Rheude ,  Walter Dobler

发明人： Wolfgang Krause ,  Hansgeorg Ernst ,  Joachim Paust ,  Udo Rheude ,  Walter Dobler

IPC分类号： C07C67/307 ,  C07F9/40 ,  C07C69/65

CPC分类号： C07F9/4015 ,  C07C67/307

摘要： A process for the preparation of alkyl esters of 0,0-dialkyl-4-phosphono-2-methyl-2-butenoic acid containing a high percentage of E isomers, wherein the corresponding alkyl esters of 2-hydroxy-2-methyl-3-butenoic acid are caused to react with PBr.sub.3 or PCl.sub.3 at temperatures ranging from 0.degree. to 80.degree. C. in the absence of pyridine and, if desired, the resulting mixture comprising predominantly alkyl esters of 4-halo-2-methyl-2-butenoic acid is caused to react with trialkyl esters of phosphorous acid at temperatures ranging from 70.degree. to 140.degree. C. The end products are desirable C.sub.5 building blocks for polyene syntheses or preceding stages.

摘要翻译： 一种制备含有高百分比的E异构体的0-二烷基-4-膦酰基-2-甲基-2-丁烯酸的烷基酯的方法，其中相应的2-羟基-2-甲基-3 在不存在吡啶的情况下，在0℃至80℃的温度范围内引发 - 丁烯酸与PBr 3或PCl 3反应，如果需要，所得混合物主要包含4-卤代-2-甲基-2- 使丁烯酸在70℃至140℃的温度范围内与亚磷酸三烷基酯反应。最终产物是用于多烯合成或先前阶段的所需C5构建块。

公开(公告)号：US5455362A

公开(公告)日：1995-10-03

申请号：US265741

申请日：1994-06-27

申请人： Hansgeorg Ernst ,  Walter Dobler ,  Joachim Paust ,  Udo Rheude

发明人： Hansgeorg Ernst ,  Walter Dobler ,  Joachim Paust ,  Udo Rheude

IPC分类号： C07C41/18 ,  C07C45/45 ,  C07C49/303 ,  C07C403/24 ,  C07D317/46 ,  C07D317/50 ,  C07D317/54 ,  C07D407/06 ,  C07D407/12 ,  C07F9/54 ,  C09B23/10

CPC分类号： C07C403/24 ,  C07C403/04 ,  C07C403/08 ,  C07C403/10 ,  C07D317/46 ,  C07F9/5435 ,  C07F9/5442 ,  C07C2101/16 ,  Y02P20/55

摘要： Compounds of the formula I ##STR1## where R.sup.1 is H or C.sub.1 -C.sub.4 -alkyl,R.sup.2 is C.sub.1 -C.sub.4 -alkyl and R.sup.3 is an ether, silyl ether or acetal protective group which can be converted into a hydroxyl group by hydrolysis, in particular one of the radicals ##STR2## and a process for preparing these compounds by reacting an alkenyne of the formula II ##STR3## in an inert solvent in the presence of lithium amide with a cyclohexenone of the formula III ##STR4## and the use of the compounds of the formula I for preparing astaxanthin, are described.

摘要翻译： 其中R 1是H或C 1 -C 4 - 烷基，R 2是C 1 -C 4 - 烷基和R 3是醚的式I化合物（I），甲硅烷基醚或缩醛保护基，其可以通过以下方式转化成羟基： 水解，特别是一个基团“IMAGE”，以及通过在惰性溶剂中在酰胺与式III的环己烯酮的存在下使式II的烯烃（II）反应来制备这些化合物的方法， IMAGE>（III）和使用式I化合物制备虾青素。

公开(公告)号：US07090748B2

公开(公告)日：2006-08-15

申请号：US10319715

申请日：2002-12-16

申请人： Gerd Kaibel ,  Christian Miller ,  Katrin Klass ,  Alois Kindler ,  Werner Aquila ,  Walter Dobler ,  Klaus Breuer ,  Achim Pommer ,  Thomas Dirnsteiner

发明人： Gerd Kaibel ,  Christian Miller ,  Katrin Klass ,  Alois Kindler ,  Werner Aquila ,  Walter Dobler ,  Klaus Breuer ,  Achim Pommer ,  Thomas Dirnsteiner

IPC分类号： B01D3/00

CPC分类号： B01D3/141 ,  B01D3/14 ,  Y10S203/11 ,  Y10S203/20

摘要： A dividing-wall column having a dividing wall which is essentially disposed along the long direction of the column is proposed, which divides the column interior into a feed part, a take off part, an upper shared column part and a lower shared column part, with feed in whole or in part in the vaporous state of a mixture to be separated between the upper region of the feed part and the lower region of the feed part and/or side stream take off in whole or in part in the vaporous state between the upper region of the take off part and the lower region of the take off part, where if feed is in whole or in part in the vaporous state the cross-sectional area of the upper region of the feed part is increased by plane-parallel displacement of the dividing wall toward the upper region of the take off part, and/or if the side stream take off is in whole or in part in the vaporous state, the cross-sectional area of the lower region of the take off part is increased by displacement of the dividing wall toward the lower region of the feed part, in such a manner that the F factor is substantially the same in all column regions.

公开(公告)号：US20050016830A1

公开(公告)日：2005-01-27

申请号：US10497520

申请日：2002-12-05

申请人： Gerd Kaibel ,  Christian Miller ,  Walter Dobler ,  Thomas Dirnsteiner ,  Marcus Sigl ,  Helmut Jansen ,  Bjorn Kaibel

发明人： Gerd Kaibel ,  Christian Miller ,  Walter Dobler ,  Thomas Dirnsteiner ,  Marcus Sigl ,  Helmut Jansen ,  Bjorn Kaibel

IPC分类号： B01D3/26 ,  B01D3/00 ,  B01J8/00 ,  B01J8/02 ,  B01J8/04 ,  B01J8/12 ,  B01J19/24 ,  B01J19/32 ,  B01J21/04 ,  B01J23/10 ,  B01J35/02 ,  C07B61/00 ,  C07C45/72 ,  C07C45/74 ,  C07C49/203 ,  B01D3/34

CPC分类号： C07C45/74 ,  B01D3/009 ,  B01J8/003 ,  B01J8/0292 ,  B01J8/12 ,  B01J19/249 ,  B01J19/32 ,  B01J21/04 ,  B01J23/10 ,  B01J35/026 ,  B01J2219/2453 ,  B01J2219/2459 ,  B01J2219/2471 ,  B01J2219/2481 ,  B01J2219/2497 ,  B01J2219/3221 ,  B01J2219/32217 ,  B01J2219/32227 ,  B01J2219/32237 ,  B01J2219/32258 ,  B01J2219/32262 ,  B01J2219/32408 ,  B01J2219/32466 ,  B01J2219/326 ,  C07C45/72 ,  Y02P20/127 ,  Y10S203/06 ,  C07C49/203

摘要： A column is described for carrying out reactive distillations in the presence of a heterogeneous particulate catalyst having an ordered packing or random packings which form intermediate spaces in the column interior, the quotient of the hydraulic diameter for the gas flow through the ordered packing or the random packings and the equivalent diameter of the catalyst particles being in the range from 2 to 20, preferably in the range from 5 to 10, in such a manner that the catalyst particles are introduced into the intermediate spaces, distributed and discharged loose under the action of gravity.

摘要翻译： 描述了一种柱，用于在具有在柱内部形成中间空间的有序填料或无规填料的非均相颗粒催化剂存在下进行反应性蒸馏，通过有序填料的气流的液压直径或随机的 填料和催化剂颗粒的当量直径在2至20范围内，优选在5至10范围内，使得催化剂颗粒被引入中间空间，在 重力。

公开(公告)号：US5384381A

公开(公告)日：1995-01-24

申请号：US152740

申请日：1993-11-15

申请人： Klaus Kohlhammer ,  Hermann Petersen ,  Walter Dobler

发明人： Klaus Kohlhammer ,  Hermann Petersen ,  Walter Dobler

IPC分类号： C08F291/00 ,  C07C409/38 ,  C08F4/34 ,  C08F261/06 ,  C08F293/00 ,  C08F218/04

CPC分类号： C08F261/06 ,  C08F293/00

摘要： Graft copolymers having improved phase binding between the graft base and the grafted-on polymer, are prepared from:a) a grafted-on polymer phase containing one or more monomers from the group consisting of (meth)acrylates of alcohols having 1 to 10 carbon atoms, vinyl esters of saturated aliphatic carboxylic acids having 2 to 10 carbon atoms, olefins, vinyl halides, styrene and styrene derivatives, andb) a peroxy group-containing copolymer phase containing from 0.01 to 20% by weight of an olefinically unsaturated peroxy compound of the general formula I or II ##STR1## where R.sup.1 is a chemical bond or a linear or branched alkyl chain having 1 to 10 carbon atoms or a cycloalkyl group having 3 to 10 carbon atoms, R.sup.2 and R.sup.3 are an alkyl group having 1 to 4 carbon atoms, R.sup.4 is an alkyl group or an alkyl-substituted phenyl group having 3 to 12 carbon atoms, and R.sup.5 is a cycloalkyl group having 3 to 12 carbon atoms, and from 80 to 99.9% by weight of one or more comonomers from the group consisting of the (meth)acrylates of alcohols having 1 to 10 carbon atoms, vinyl esters of saturated aliphatic carboxylic acids having 2 to 10 carbon atoms, olefins, vinylaromatic compounds, vinyl halides and/or vinyl ethers.The graft copolymers are useful as binders in the textile industry as heat stable binders, as adhesives in plasters and as binders in emulsion paints.

摘要翻译： 具有改进的接枝基质和接枝聚合物之间的相结合的接枝共聚物由以下物质制备：a）接枝聚合物相，其含有一种或多种由具有1至10个碳的醇的（甲基）丙烯酸酯组成的组中的单体 原子，具有2-10个碳原子的饱和脂族羧酸的乙烯基酯，烯烃，乙烯基卤化物，苯乙烯和苯乙烯衍生物，和b）含有0.01-20重量％的烯属不饱和过氧化合物 其中R 1是化学键或具有1至10个碳原子的直链或支链烷基或具有3至10个碳原子的环烷基，所述通式I或II其中R 1， R2和R3是具有1至4个碳原子的烷基，R4是烷基或具有3-12个碳原子的烷基取代的苯基，R5是具有3-12个碳原子的环烷基，从80到 99.9重量％的一种或多种共聚单体f 由具有1-10个碳原子的（甲基）丙烯酸酯，具有2-10个碳原子的饱和脂族羧酸的乙烯基酯，烯烃，乙烯基芳族化合物，乙烯基卤化物和/或乙烯基醚构成的组中。 接枝共聚物可用作纺织工业中的粘合剂，作为热稳定粘合剂，作为膏药中的粘合剂和乳液涂料中的粘合剂。