公开(公告)号：US08563133B2

公开(公告)日：2013-10-22

申请号：US11299299

申请日：2005-12-09

Applicant: Jeffery A. Whiteford ,  Mihai A. Buretea ,  Jian Chen ,  William P. Freeman ,  Andreas Meisel ,  Linh Nguyen ,  J. Wallace Parce ,  Erik Scher

Inventor： Jeffery A. Whiteford ,  Mihai A. Buretea ,  Jian Chen ,  William P. Freeman ,  Andreas Meisel ,  Linh Nguyen ,  J. Wallace Parce ,  Erik Scher

IPC: B32B5/16

CPC classification number: B05D5/12 ,  C07F5/025 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

Abstract: Ligand compositions for use in preparing discrete coated nanostructures are provided, as well as the coated nanostructures themselves and devices incorporating same. Methods for post-deposition shell formation on a nanostructure, for reversibly modifying nanostructures, and for manipulating the electronic properties of nanostructures are also provided. The ligands and coated nanostructures of the present invention are particularly useful for close packed nanostructure compositions, which can have improved quantum confinement and/or reduced cross-talk between nanostructures. Ligands of the present invention are also useful for manipulating the electronic properties of nanostructure compositions (e.g., by modulating energy levels, creating internal bias fields, reducing charge transfer or leakage, etc.).

公开(公告)号：US20110300114A1

公开(公告)日：2011-12-08

申请号：US12514773

申请日：2007-11-12

Applicant: Josef Priller ,  Christel Bonnas ,  Andreas Meisel

Inventor： Josef Priller ,  Christel Bonnas ,  Andreas Meisel

IPC: C12N5/071 ,  C12N5/074 ,  C12N5/09 ,  C12N5/0775 ,  A61K48/00 ,  A61P9/00 ,  A61P25/00 ,  A61P1/16 ,  A61P1/18 ,  A61P13/02 ,  A61P13/12 ,  A61P15/00 ,  A61P19/00 ,  A61P19/02 ,  A61P35/00 ,  C12N5/0735

CPC classification number: C07K14/505 ,  A61K35/12 ,  A61K38/00 ,  C12N5/0018 ,  C12N2501/14

Abstract: In one aspect the present invention is concerned with a method of cell culture, comprising the steps of (i) obtaining a stem or progenitor cell sample, (ii) culturing the stem or progenitor cell sample in media and under closed conditions appropriate to cause proliferation or differentiation of the stem or progenitor cells, wherein the media comprises a vEPO protein variant, (iii) purifying the stem or progenitor cells ex vivo. The invention relates to a method of increasing the number and survival of stem and progenitor cells in vitro and in vivo using a vEPO protein variant. The invention also relates to improved differentiation of stem and progenitor cells in vitro and in vivo using a vEPO protein variant.

Abstract translation: 一方面，本发明涉及细胞培养的方法，其包括以下步骤：（i）获得干细胞或祖细胞样品，（ii）培养干细胞或祖细胞样品在培养基中并在适于引起扩散的封闭条件下 或分化干细胞或祖细胞，其中培养基包含vEPO蛋白质变体，（iii）离体纯化干细胞或祖细胞。 本发明涉及使用vEPO蛋白质变体在体外和体内增加干细胞和祖细胞的数量和存活率的方法。 本发明还涉及使用vEPO蛋白质变体在体外和体内改进干细胞和祖细胞的分化。

公开(公告)号：US20100139770A1

公开(公告)日：2010-06-10

申请号：US11499599

申请日：2006-08-04

Applicant: Erik Scher ,  Mihai A. Buretea ,  Calvin Chow ,  Stephen Empedocles ,  Andreas Meisel ,  J. Wallace Parce

Inventor： Erik Scher ,  Mihai A. Buretea ,  Calvin Chow ,  Stephen Empedocles ,  Andreas Meisel ,  J. Wallace Parce

IPC: H01L31/00

CPC classification number: H01L31/04 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  H01L31/0384 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/4213 ,  H01L51/4226 ,  H01L51/426 ,  Y02E10/549 ,  Y02P70/521

Abstract: Nanocomposite photovoltaic devices are provided that generally include semiconductor nanocrystals as at least a portion of a photoactive layer. Photovoltaic devices and other layered devices that comprise core-shell nanostructures and/or two populations of nanostructures, where the nanostructures are not necessarily part of a nanocomposite, are also features of the invention. Varied architectures for such devices are also provided including flexible and rigid architectures, planar and non-planar architectures and the like, as are systems incorporating such devices, and methods and systems for fabricating such devices. Compositions comprising two populations of nanostructures of different materials are also a feature of the invention.

Abstract translation: 提供纳米复合光伏器件，其通常包括作为光活性层的至少一部分的半导体纳米晶体。 包含核 - 壳纳米结构和/或两组纳米结构的光伏器件和其它分层器件，其中纳米结构不一定是纳米复合材料的一部分，也是本发明的特征。 还提供了用于这种装置的各种架构，包括柔性和刚性架构，平面和非平面架构等，以及结合这种装置的系统，以及用于制造这种装置的方法和系统。 包含两种不同材料的纳米结构群的组合物也是本发明的特征。

公开(公告)号：US20100136771A1

公开(公告)日：2010-06-03

申请号：US12493946

申请日：2009-06-29

Applicant: Hyungrak Kim ,  Malcolm Abbott ,  Andreas Meisel ,  Elizabeth Tai ,  Augustus Jones ,  Dmitry Poplavskyy ,  Karel Vanheusden

Inventor： Hyungrak Kim ,  Malcolm Abbott ,  Andreas Meisel ,  Elizabeth Tai ,  Augustus Jones ,  Dmitry Poplavskyy ,  Karel Vanheusden

IPC: H01L21/208 ,  H01B1/02 ,  H01B1/22

CPC classification number: H01L21/02532 ,  H01L21/02381 ,  H01L21/02601 ,  H01L21/02628 ,  H01L21/02658

Abstract: A Group IV based nanoparticle fluid is disclosed. The nanoparticle fluid includes a set of nanoparticles—comprising a set of Group IV atoms, wherein the set of nanoparticles is present in an amount of between about 1 wt % and about 20 wt % of the nanoparticle fluid. The nanoparticle fluid also includes a set of HMW molecules, wherein the set of HMW molecules is present in an amount of between about 0 wt % and about 5 wt % of the nanoparticle fluid. The nanoparticle fluid further includes a set of capping agent molecules, wherein at least some capping agent molecules of the set of capping agent molecules are attached to the set of nanoparticles.

Abstract translation: 公开了基于IV族的纳米颗粒流体。 纳米颗粒流体包括一组纳米颗粒，其包含一组IV族原子，其中所述纳米颗粒组以纳米颗粒流体的约1重量％至约20重量％的量存在。 纳米颗粒流体还包括一组HMW分子，其中该组HMW分子以纳米颗粒流体的约0重量％至约5重量％的量存在。 纳米颗粒流体还包括一组封端剂分子，其中所述一组封端剂分子的至少一些封端剂分子连接到该组纳米颗粒上。

公开(公告)号：US07662313B2

公开(公告)日：2010-02-16

申请号：US10656911

申请日：2003-09-04

Applicant: Jeffery A. Whiteford ,  Mihai Buretea ,  Erik Scher ,  Steve Empedocles ,  Andreas Meisel

Inventor： Jeffery A. Whiteford ,  Mihai Buretea ,  Erik Scher ,  Steve Empedocles ,  Andreas Meisel

IPC: H01B1/00 ,  C07D333/50 ,  C07F9/22

CPC classification number: B82B1/00 ,  B82Y10/00 ,  B82Y30/00

Abstract: This invention provides compositions and devices having structurally ordered nanostructures, as well as methods for producing structurally ordered nanostructures.

Abstract translation: 本发明提供了具有结构有序纳米结构的组合物和装置，以及用于生产结构有序纳米结构的方法。

公开(公告)号：US07585564B2

公开(公告)日：2009-09-08

申请号：US11706730

申请日：2007-02-13

Applicant: Jeffery A. Whiteford ,  Mihai Buretea ,  William P. Freeman ,  Andreas Meisel ,  Kyu S. Min ,  J. Wallace Parce ,  Erik Scher

Inventor： Jeffery A. Whiteford ,  Mihai Buretea ,  William P. Freeman ,  Andreas Meisel ,  Kyu S. Min ,  J. Wallace Parce ,  Erik Scher

IPC: B32B5/66

CPC classification number: C09C1/3081 ,  B82Y30/00 ,  C01P2004/16 ,  C01P2004/45 ,  C01P2004/54 ,  C01P2004/64 ,  C01P2006/10 ,  C01P2006/40 ,  C01P2006/60 ,  C09C3/006 ,  C09C3/063 ,  C09C3/12 ,  H01G4/14 ,  Y10S977/773 ,  Y10T428/2982 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

Abstract: Ligand compositions for use in preparing discrete coated nanostructures are provided, as well as the coated nanostructures themselves and devices incorporating same. Methods for post-deposition shell formation on a nanostructure and for reversibly modifying nanostructures are also provided. The ligands and coated nanostructures of the present invention are particularly useful for close packed nanostructure compositions, which can have improved quantum confinement and/or reduced cross-talk between nanostructures.

Abstract translation: 提供了用于制备离散涂层纳米结构的配体组合物，以及涂覆的纳米结构本身和结合其的装置。 还提供了在纳米结构上沉积后壳形成和用于可逆修饰纳米结构的方法。 本发明的配体和包被的纳米结构对于紧密堆积的纳米结构组合物是特别有用的，其可以改进纳米结构的量子限制和/或减少的串扰。

公开(公告)号：US20080032134A1

公开(公告)日：2008-02-07

申请号：US11706730

申请日：2007-02-13

Applicant: Jeffery Whiteford ,  Rhett Brewer ,  Mihai Buretea ,  Jian Chen ,  Karen Cruden ,  Xiangfeng Duan ,  William Freeman ,  David Heald ,  Francisco Leon ,  Chao Liu ,  Andreas Meisel ,  Kyu Min ,  J. Parce ,  Erik Scher

Inventor： Jeffery Whiteford ,  Rhett Brewer ,  Mihai Buretea ,  Jian Chen ,  Karen Cruden ,  Xiangfeng Duan ,  William Freeman ,  David Heald ,  Francisco Leon ,  Chao Liu ,  Andreas Meisel ,  Kyu Min ,  J. Parce ,  Erik Scher

IPC: B32B5/16 ,  B32B15/04 ,  B32B17/06

CPC classification number: C09C1/3081 ,  B82Y30/00 ,  C01P2004/16 ,  C01P2004/45 ,  C01P2004/54 ,  C01P2004/64 ,  C01P2006/10 ,  C01P2006/40 ,  C01P2006/60 ,  C09C3/006 ,  C09C3/063 ,  C09C3/12 ,  H01G4/14 ,  Y10S977/773 ,  Y10T428/2982 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

Abstract: Ligand compositions for use in preparing discrete coated nanostructures are provided, as well as the coated nanostructures themselves and devices incorporating same. Methods for post-deposition shell formation on a nanostructure and for reversibly modifying nanostructures are also provided. The ligands and coated nanostructures of the present invention are particularly useful for close packed nanostructure compositions, which can have improved quantum confinement and/or reduced cross-talk between nanostructures.

Abstract translation: 提供了用于制备离散涂层纳米结构的配体组合物，以及涂覆的纳米结构本身和结合其的装置。 还提供了在纳米结构上沉积后壳形成和用于可逆修饰纳米结构的方法。 本发明的配体和包被的纳米结构对于紧密堆积的纳米结构组合物是特别有用的，其可以改进纳米结构的量子限制和/或减少的串扰。

公开(公告)号：US20050150541A1

公开(公告)日：2005-07-14

申请号：US11007916

申请日：2004-12-09

Applicant: Erik Scher ,  Mihai Buretea ,  Calvin Chow ,  Stephen Empedocles ,  Andreas Meisel ,  J. Parce

Inventor： Erik Scher ,  Mihai Buretea ,  Calvin Chow ,  Stephen Empedocles ,  Andreas Meisel ,  J. Parce

IPC: B82B1/00 ,  H01L20060101 ,  H01L31/00 ,  H01L31/0256 ,  H01L31/0264 ,  H01L31/0272 ,  H01L31/0296 ,  H01L31/0352 ,  H01L31/036 ,  H01L31/0384 ,  H01L51/00 ,  H01L51/42

CPC classification number: H01L31/04 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  H01L31/0384 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/4213 ,  H01L51/4226 ,  H01L51/426 ,  Y02E10/549 ,  Y02P70/521

Abstract: Nanocomposite photovoltaic devices are provided that generally include semiconductor nanocrystals as at least a portion of a photoactive layer. Photovoltaic devices and other layered devices that comprise core-shell nanostructures and/or two populations of nanostructures, where the nanostructures are not necessarily part of a nanocomposite, are also features of the invention. Varied architectures for such devices are also provided including flexible and rigid architectures, planar and non-planar architectures and the like, as are systems incorporating such devices, and methods and systems for fabricating such devices. Compositions comprising two populations of nanostructures of different materials are also a feature of the invention.

公开(公告)号：US20130040421A1

公开(公告)日：2013-02-14

申请号：US13358131

申请日：2012-01-25

Applicant: Andreas Meisel

Inventor： Andreas Meisel

IPC: H01L31/18

CPC classification number: H01L31/1804 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  H01L31/022425 ,  H01L31/022441 ,  Y02E10/547 ,  Y02P70/521

Abstract: A method for calculating an offset value for aligned deposition of a second pattern onto a first pattern, comprising steps of: (a) loading a substrate with the first pattern on a surface of the substrate into a pattern recognition device at an original position inside the pattern recognition device; (b) determining a coordinate of a prescribed point of the first pattern by the pattern recognition device; (c) superimposing the second pattern onto the first pattern on the surface of the substrate; (d) bringing back the substrate with the first pattern and the second pattern into the original position inside the pattern recognition device; (e) determining a coordinate of a prescribed point of the second pattern by the pattern recognition device; wherein the prescribed point of the first pattern corresponds to the prescribed point of the second pattern; and (f) calculating the offset value between the first pattern and the second pattern.

Abstract translation: 一种用于计算用于将第二图案对准沉积到第一图案上的偏移值的方法，包括以下步骤：（a）将基板的表面上的第一图案的基板加载到图案识别装置内部的原始位置 图案识别装置; （b）通过图案识别装置确定第一图案的规定点的坐标; （c）将第二图案叠加在基板的表面上的第一图案上; （d）将具有第一图案和第二图案的基板返回到图案识别装置内部的原始位置; （e）通过图案识别装置确定第二图案的规定点的坐标; 其中所述第一图案的规定点对应于所述第二图案的规定点; 和（f）计算第一图案和第二图案之间的偏移值。

公开(公告)号：US20110008363A1

公开(公告)日：2011-01-13

申请号：US12334995

申请日：2008-12-15

Applicant: Andreas Meisel ,  Josef Priller ,  Christel Bonnas ,  Ulrich Dirnagl

Inventor： Andreas Meisel ,  Josef Priller ,  Christel Bonnas ,  Ulrich Dirnagl

IPC: A61K39/395 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  A01K67/033 ,  C12P21/00 ,  C07K14/505 ,  C07K16/18 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/18 ,  A61P9/10

CPC classification number: C07K14/505 ,  A61K38/00 ,  C07K2319/00

Abstract: The present invention relates to novel endogenous variants of erythropoietin (EPO) and their use for treatment or prevention of a condition associated with tissue damage due to cell death (apoptosis, necrosis) and inflammation, in particular for neuroprotection, e.g. treatment of acute (for example stroke) and chronic disease (for example ALS) of the nervous system.

Abstract translation: 本发明涉及促红细胞生成素（EPO）的新型内源性变体及其用于治疗或预防与细胞死亡（细胞凋亡，坏死）和炎症有关的组织损伤相关病症的用途，特别是用于神经保护作用。 治疗神经系统的急性（例如中风）和慢性疾病（例如ALS）。