公开(公告)号：US20070110633A1

公开(公告)日：2007-05-17

申请号：US11617809

申请日：2006-12-29

Applicant: Steven Sundberg ,  J. Parce ,  Calvin Chow

Inventor： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC: B01L3/00

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20070034833A1

公开(公告)日：2007-02-15

申请号：US11492717

申请日：2006-07-24

Applicant: J. Parce ,  Paul Bernatis ,  Robert Dubrow ,  William Freeman ,  Joel Gamoras ,  Shihai Kan ,  Andreas Meisel ,  Baixin Qian ,  Jeffery Whiteford ,  Jonathan Ziebarth

Inventor： J. Parce ,  Paul Bernatis ,  Robert Dubrow ,  William Freeman ,  Joel Gamoras ,  Shihai Kan ,  Andreas Meisel ,  Baixin Qian ,  Jeffery Whiteford ,  Jonathan Ziebarth

IPC: C09K11/02

CPC classification number: C09K11/02 ,  B82Y20/00 ,  B82Y30/00 ,  C01B19/007 ,  C01G9/08 ,  C01P2002/72 ,  C01P2002/84 ,  C01P2004/04 ,  C01P2004/64 ,  C01P2004/80 ,  C01P2004/84 ,  C09K11/565 ,  C09K11/70 ,  C09K11/883 ,  G02B1/11 ,  G02B3/0087 ,  G02B2207/101 ,  H01L33/502 ,  Y10S977/783

Abstract: Matrixes doped with semiconductor nanocrystals are provided. In certain embodiments, the semiconductor nanocrystals have a size and composition such that they absorb or emit light at particular wavelengths. The nanocrystals can comprise ligands that allow for mixing with various matrix materials, including polymers, such that a minimal portion of light is scattered by the matrixes. The matrixes of the present invention can also be utilized in refractive index matching applications. In other embodiments, semiconductor nanocrystals are embedded within matrixes to form a nanocrystal density gradient, thereby creating an effective refractive index gradient. The matrixes of the present invention can also be used as filters and antireflective coatings on optical devices and as down-converting layers. Processes for producing matrixes comprising semiconductor nanocrystals are also provided. Nanostructures having high quantum efficiency, small size, and/or a narrow size distribution are also described, as are methods of producing indium phosphide nanostructures and core-shell nanostructures with Group II-VI shells.

Abstract translation: 提供掺杂半导体纳米晶体的矩阵。 在某些实施方案中，半导体纳米晶体具有使其吸收或发射特定波长的光的尺寸和组成。 纳米晶体可以包括允许与各种基质材料（包括聚合物）混合的配体，使得最小部分的光被基质散射。 本发明的基质也可用于折射率匹配应用。 在其它实施例中，将半导体纳米晶体嵌入在基质内以形成纳米晶体密度梯度，从而产生有效的折射率梯度。 本发明的基质也可以用作光学器件上的滤光片和抗反射涂层以及下变换层。 还提供了用于生产包含半导体纳米晶体的基质的方法。 还描述了具有高量子效率，小尺寸和/或窄尺寸分布的纳米结构，以及生产具有II-VI族壳的磷化铟纳米结构和核 - 壳纳米结构的方法。

公开(公告)号：US20060286002A1

公开(公告)日：2006-12-21

申请号：US11493998

申请日：2006-07-27

Applicant: Steven Sundberg ,  J. Parce ,  Calvin Chow

Inventor： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC: B01L3/02

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20060286001A1

公开(公告)日：2006-12-21

申请号：US11493997

申请日：2006-07-27

Applicant: Steven Sundberg ,  J. Parce ,  Calvin Chow

Inventor： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC: B01L3/02

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20060275817A1

公开(公告)日：2006-12-07

申请号：US11460550

申请日：2006-08-11

Applicant: J. Parce ,  Theo Nikiforov ,  Tammy Mehta ,  Anne Kopf-Sill ,  Andrea Chow ,  Michael Knapp

Inventor： J. Parce ,  Theo Nikiforov ,  Tammy Mehta ,  Anne Kopf-Sill ,  Andrea Chow ,  Michael Knapp

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0487 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6869 ,  C40B60/14 ,  G01N27/44756 ,  G01N35/0098 ,  G01N2035/00574 ,  Y10T436/143333 ,  C12Q2565/629 ,  C12Q2535/101 ,  C12Q2563/173 ,  C12Q2525/186 ,  C12Q2527/125

Abstract: Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by incorporation of the fluorescently labeled nucleotide, optionally followed by photobleaching and intercalating dyes are used to detect addition of a non-labeled nucleotide in sequencing by synthesis with detection by intercalation. Microfluidic devices, including particle arrays, are used in the sequencing methods.

Abstract translation: 核苷酸和核苷酸类似物通过合成方法的并入/测序用于各种测序。 包含3'-封闭基团的核苷酸类似物用于提供可逆的链终止，用于通过合成进行测序。 典型的封闭基团包括磷酸基和氨基甲酸酯基。 使用荧光核苷酸进行测序，通过掺入荧光标记的核苷酸进行检测，任选地随后进行光漂白，并使用嵌入染料检测通过插入检测合成测序中的未标记核苷酸的添加。 微流控器件，包括粒子阵列，用于测序方法。

公开(公告)号：US20060040103A1

公开(公告)日：2006-02-23

申请号：US11147670

申请日：2005-06-07

Applicant: Jeffery Whiteford ,  Rhett Brewer ,  Mihai Buretea ,  Jian Chen ,  Karen Cruden ,  Xiangfeng Duan ,  William Freeman ,  David Heald ,  Francisco Leon ,  Chao Liu ,  Andreas Meisel ,  Kyu Min ,  J. Parce ,  Erik Scher

Inventor： Jeffery Whiteford ,  Rhett Brewer ,  Mihai Buretea ,  Jian Chen ,  Karen Cruden ,  Xiangfeng Duan ,  William Freeman ,  David Heald ,  Francisco Leon ,  Chao Liu ,  Andreas Meisel ,  Kyu Min ,  J. Parce ,  Erik Scher

IPC: B32B5/16

CPC classification number: C09C1/3081 ,  B82Y30/00 ,  C01P2004/16 ,  C01P2004/45 ,  C01P2004/54 ,  C01P2004/64 ,  C01P2006/10 ,  C01P2006/40 ,  C01P2006/60 ,  C09C3/006 ,  C09C3/063 ,  C09C3/12 ,  H01G4/14 ,  Y10S977/773 ,  Y10T428/2982 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

Abstract: Ligand compositions for use in preparing discrete coated nanostructures are provided, as well as the coated nanostructures themselves and devices incorporating same. Methods for post-deposition shell formation on a nanostructure and for reversibly modifying nanostructures are also provided. The ligands and coated nanostructures of the present invention are particularly useful for close packed nanostructure compositions, which can have improved quantum confinement and/or reduced cross-talk between nanostructures.

公开(公告)号：US20050287717A1

公开(公告)日：2005-12-29

申请号：US11148001

申请日：2005-06-07

Applicant: David Heald ,  Karen Cruden ,  Xiangfeng Duan ,  Chao Liu ,  J. Parce

Inventor： David Heald ,  Karen Cruden ,  Xiangfeng Duan ,  Chao Liu ,  J. Parce

IPC: G03F7/075 ,  G11C13/00 ,  H01L21/28 ,  H01L21/312 ,  H01L21/469 ,  H01L21/82 ,  H01L27/10 ,  H01L29/739

CPC classification number: G03F7/0757 ,  B82Y10/00 ,  B82Y30/00 ,  G11C13/00 ,  H01L21/02137 ,  H01L21/02282 ,  H01L21/02304 ,  H01L21/28273 ,  H01L21/3124 ,  Y10S977/755 ,  Y10S977/845 ,  Y10S977/855 ,  Y10S977/936 ,  Y10S977/938

Abstract: Methods for forming or patterning nanostructure arrays are provided. The methods involve formation of arrays on coatings comprising nanostructure association groups, patterning using resist, and/or use of devices that facilitate array formation. Related devices for forming nanostructure arrays are also provided, as are devices including nanostructure arrays (e.g., memory devices).

Abstract translation: 提供了形成或构图纳米结构阵列的方法。 所述方法包括在包含纳米结构缔合基团的涂层上形成阵列，使用抗蚀剂进行图案化和/或使用便于阵列形成的装置。 还提供了用于形成纳米结构阵列的相关器件，以及包括纳米结构阵列（例如，存储器件）的器件。

公开(公告)号：US20050221385A1

公开(公告)日：2005-10-06

申请号：US11051445

申请日：2005-02-03

Applicant: Theo Nikiforov ,  Jill Baker ,  Sansan Lin ,  J. Parce ,  Jude Dunne ,  Javier Farinas ,  Esther Huang ,  Mingqing Li ,  Thi Trinh

Inventor： Theo Nikiforov ,  Jill Baker ,  Sansan Lin ,  J. Parce ,  Jude Dunne ,  Javier Farinas ,  Esther Huang ,  Mingqing Li ,  Thi Trinh

IPC: G01N30/88 ,  G01N33/53

CPC classification number: G01N30/88

Abstract: Methods for chromatographically separating materials, including the separation of materials in kinase or phosphatase assays, in microfluidic devices under positive or negative fluid pressure. Devices and integrated systems for performing chromatographic separations are also provided.

Abstract translation: 用于在正或负流体压力下在微流体装置中色谱分离材料的方法，包括在激酶或磷酸酶测定中分离材料。 还提供了用于执行色谱分离的设备和集成系统。

公开(公告)号：US20050148084A1

公开(公告)日：2005-07-07

申请号：US11069632

申请日：2005-02-28

Applicant: J. Parce ,  Morten Jensen

Inventor： J. Parce ,  Morten Jensen

IPC: B01L3/00 ,  G01N35/00

CPC classification number: B01L3/5027 ,  B01L2200/143 ,  G01N35/0092 ,  G01N2035/0093 ,  Y10T436/115831 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the duration to apply the mobility. For example, fluids can be sequentially run past down a main channel to a detection zone of the microfluidic device in order to analyze the fluids. In order to increase the efficiency of the analysis, fluids can be processed in parallel by running one fluid down the main channel while another fluid is loaded to the main channel.

Abstract translation: 提供了控制分析仪器的技术。 可以使用一系列步骤来指定微流体装置的孔，将要施加到井中的流体的移动性以及施加移动性的持续时间。 例如，为了分析流体，流体可以顺序地沿主通道向下流动到微流体装置的检测区域。 为了提高分析效率，可以通过在主通道下方运行一个流体同时将另一个流体加载到主通道来并行处理流体。

公开(公告)号：US20070238314A1

公开(公告)日：2007-10-11

申请号：US11225951

申请日：2005-09-14

Applicant: Mihai Buretea ,  Jian Chen ,  Calvin Chow ,  Chunming Niu ,  Yaoling Pan ,  J. Parce ,  Linda Romano ,  David Stumbo

Inventor： Mihai Buretea ,  Jian Chen ,  Calvin Chow ,  Chunming Niu ,  Yaoling Pan ,  J. Parce ,  Linda Romano ,  David Stumbo

IPC: H01L21/31

CPC classification number: H01L29/0665 ,  B82Y10/00 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/068 ,  H01L29/42384 ,  H01L29/66742 ,  H01L29/78681 ,  H01L29/78696 ,  H01L33/06 ,  H01L33/24 ,  H01L51/0048 ,  H01L51/0545 ,  H01L2924/0002 ,  Y10T428/2913 ,  H01L2924/00

Abstract: The present invention relates to a system and process for producing a nanowire-material composite. A substrate having nanowires attached to a portion of at least one surface is provided. A material is deposited over the portion to form the nanowire-material composite. The process further optionally comprises separating the nanowire-material composite from the substrate to form a freestanding nanowire-material composite. The freestanding nanowire material composite is optionally further processed into a electronic substrate. A variety of electronic substrates can be produced using the methods described herein. For example, a multi-color light-emitting diode can be produced from multiple, stacked layers of nanowire-material composites, each composite layer emitting light at a different wavelength.

Abstract translation: 本发明涉及纳米线材料复合体的制造方法和制造方法。 提供了具有连接到至少一个表面的一部分的纳米线的衬底。 在该部分上沉积材料以形成纳米线材料复合材料。 该方法进一步任选地包括从衬底分离纳米线材料复合物以形成独立的纳米线材料复合材料。 独立的纳米线材料复合材料任选进一步加工成电子基片。 可以使用本文所述的方法来生产各种电子基板。 例如，多个发光二极管可以由多个层叠的纳米线材料复合体制成，每个复合层发射不同波长的光。