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    Actuation of parallel microfluidic arrays
    1.
    发明申请
    Actuation of parallel microfluidic arrays 有权
    平行微流体阵列的启动

    公开(公告)号：US20080087584A1

    公开(公告)日：2008-04-17

    申请号：US11800469

    申请日：2007-05-04

    申请人： Andrew Johnson ,  John Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/36

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    Actuation of parallel microfluidic arrays
    2.
    发明授权
    Actuation of parallel microfluidic arrays 有权
    平行微流体阵列的启动

    公开(公告)号：US08123044B2

    公开(公告)日：2012-02-28

    申请号：US11800469

    申请日：2007-05-04

    申请人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/00

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    Actuation of parallel microfluidic arrays
    3.
    发明授权
    Actuation of parallel microfluidic arrays 有权
    平行微流体阵列的启动

    公开(公告)号：US08863962B2

    公开(公告)日：2014-10-21

    申请号：US13371277

    申请日：2012-02-10

    申请人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/00 ,  B07C5/34 ,  B01L3/00

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    Actuation of Parallel Microfluidic Arrays
    4.
    发明申请
    Actuation of Parallel Microfluidic Arrays 有权
    平行微流体阵列的驱动

    公开(公告)号：US20120138513A1

    公开(公告)日：2012-06-07

    申请号：US13371277

    申请日：2012-02-10

    申请人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/00 ,  H01L41/053

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错的填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    Latching micro-regulator
    7.
    发明申请
    Latching micro-regulator 审中-公开
    闭锁微调节器

    公开(公告)号：US20080086885A1

    公开(公告)日：2008-04-17

    申请号：US11973266

    申请日：2007-10-05

    申请人： John Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

    发明人： John Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

    IPC分类号： B21K1/20

    CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0005 ,  F16K99/0007 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K2099/0069 ,  F16K2099/0071 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G05D7/0694 ,  Y10T29/49412 ,  Y10T137/87314

    摘要： A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.

    摘要翻译： 用于调节微量级液体流动的闭锁微调节器包括具有入口端口和出口端口的基板，限定用于打开和关闭入口端口的阀室的阀元件以及用于致动阀元件的致动器组件。 阀室被构造成容纳一定体积的流体，并且入口端口和出口端口与阀室流体连通以提供通过该腔室的液体流动路径。 致动器组件包括用于在打开位置和关闭位置之间移动阀元件的悬臂梁，用于移动悬臂梁的致动器（例如压电元件）以及用于固定悬臂的闩锁（例如永磁体） 梁处于关闭位置。 流量调节系统包括多个不同流量的流体通道和多个用于选择性地阻塞或允许流过每个流体通道的闭锁微调节器。

    Latching micro-regulator
    8.
    发明申请
    Latching micro-regulator 有权
    闭锁微调节器

    公开(公告)号：US20050166975A1

    公开(公告)日：2005-08-04

    申请号：US11099014

    申请日：2005-04-04

    申请人： John Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

    发明人： John Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

    IPC分类号： F15C5/00 ,  F16K99/00 ,  G05D7/06

    CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0005 ,  F16K99/0007 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K2099/0069 ,  F16K2099/0071 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G05D7/0694 ,  Y10T29/49412 ,  Y10T137/87314

    摘要： A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.

    摘要翻译： 用于调节微量级液体流动的闭锁微调节器包括具有入口端口和出口端口的基板，限定用于打开和关闭入口端口的阀室的阀元件以及用于致动阀元件的致动器组件。 阀室被构造成容纳一定体积的流体，并且入口端口和出口端口与阀室流体连通以提供通过该腔室的液体流动路径。 致动器组件包括用于在打开位置和关闭位置之间移动阀元件的悬臂梁，用于移动悬臂梁的致动器（例如压电元件）以及用于固定悬臂的闩锁（例如永磁体） 梁处于关闭位置。 流量调节系统包括多个不同流量的流体通道和多个用于选择性地阻塞或允许流过每个流体通道的闭锁微调节器。