摘要:
The present invention discloses compounds of general formula (I) wherein X1-X4 and R1-R3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.
摘要:
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
摘要:
The present invention relates to oximes and hydrazones of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
摘要:
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1 are as described in the specification.
摘要:
The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B, are as described in the specification.
摘要:
The present invention discloses a method of introducing a nutraceutical to a beverage comprising treating a beverage with a primary sterilizing agent, such as ozonation, filling a container with said beverage, adding an amount of a nutraceutical and sealing said container. The present invention allows for the production of a suitably sterile beverage without a substantial loss in the activity, or change in the structure, of a nutraceutical.
摘要:
The present device is a hanger bearing coupling which includes a bearing for supporting a shaft, the bearing including an inner race mounted onto the shaft, the bearing mounted between at least two hub assemblies mounted one on either side of the bearing on the shaft; and a hanger including an opening for receiving the bearing there through for operably connecting the bearing to the hanger. Each hub assembly including an inner flex hub mounted to the shaft and an outer flex hub resiliently mounted to the inner flex hub wherein the outer flex hubs are adapted to connect to tubular shafts which may be longitudinally misaligned.
摘要:
A skate boot with a rear element that includes a tendon guard upwardly extending from an outsole of the boot is disclosed. The rear element covers at least a rear portion of an ankle received within the boot. The rear element has a base in connection with a heel portion of the outsole such that the rear element is displaceable relative a remainder of the boot in a forward and rearward direction about the connection. The rear element is an external element of the boot, and has a desired flexibility allowing the rear element to flex in the forward and rearward direction following a given forward and rearward flexion of the ankle.
摘要:
A system and method for updating a computer program on a mobile computing device comprises uploading of packages to a repository, wherein each package comprises update data for a different portion of the computer program, a server identifying portions of the computer program to be updated on a device based on comparing information reported by the device and metadata about packages in the repository and a download server configured to wirelessly download the packages to the mobile computing device. The device may report back installation status to a server.
摘要:
A method for synthesizing a given peptide or its derivative which contains a proline residue or a proline derivative, at proximity to, or at, the C-terminal end of said peptide is provided. The method comprises a) synthesizing on a first resin a C-terminal portion of said peptide, or its derivative, comprising at least three successive amino acid residues or their derivatives, by successive coupling of selected amino acids, small peptides or their derivatives; b) cleaving the C-terminal portion from said first resin; c) reattaching said C-terminal portion to a second resin which is generally suitable for the synthesis of peptides but is unsuitable for the formation of peptides having a proline residue positioned at the C-terminal end of said peptide; and d) coupling selected amino acids, small peptides or derivatives to the C-terminal portion.