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    Glial cell line-derived neurotrophic factor receptor
    3.
    发明申请
    Glial cell line-derived neurotrophic factor receptor 审中-公开

    公开(公告)号：US20060166325A1

    公开(公告)日：2006-07-27

    申请号：US11332638

    申请日：2006-01-12

    申请人： Gary Fox ,  Shuqian Jing ,  Duanzhi Wen

    发明人： Gary Fox ,  Shuqian Jing ,  Duanzhi Wen

    IPC分类号： A61K38/17 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/715 ,  A61K38/00 ,  C07K14/71

    摘要： The present invention relates to glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophin that exhibits a broad spectrum of biological activities on a variety of cell types from both the central and peripheral nervous systems. The present invention involves the cloning and characterization of a high affinity receptor for GDNF. This molecule has been named GDNF receptor (GDNFR) since it is the first known component of a receptor system. Nucleic acid and amino acid sequences are described for GDNFR protein products. A hydrophobic domain with the features of a signal peptide is found at the amino terminus, while a second hydrophobic domain at the carboxy terminus is involved in the linkage of the receptor to the cell membrane. The lack of a transmembrane domain and cytoplasmic region indicates that GDNFR requires one or more accessory molecules in order to mediate transmembrane signaling. GDNFR mRNA is widely distributed in both nervous system and non-neural tissues, consistent with the similar distribution found for GDNF.

    Ligands for EPH-like receptors
    5.
    发明申请
    Ligands for EPH-like receptors 审中-公开
    配体用于EPH样受体

    公开(公告)号：US20050106674A1

    公开(公告)日：2005-05-19

    申请号：US11022400

    申请日：2004-12-21

    申请人： Timothy Bartley ,  Gary Fox

    发明人： Timothy Bartley ,  Gary Fox

    IPC分类号： G01N33/566 ,  A61K38/00 ,  A61P1/16 ,  A61P11/00 ,  A61P25/00 ,  A61P43/00 ,  C07K14/47 ,  C07K14/52 ,  C07K16/18 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19 ,  C07K14/705 ,  C07H21/04

    CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K2319/00

    摘要： Polypeptides which bind to one or more EPH-like receptors, particularly the HEK4 receptor, are described. The polypeptides are designated HEK4 binding proteins. Nucleic acids encoding HEK4 binding proteins, and expression vectors, host cells and processes for the production of the polypeptides are also described. The polypeptides are useful for modulating the growth and/or differentiation of a variety of tissues, including those from liver, kidney, lung, skin, digestive tract and nervous system and may be used to regenerate damaged or depleted tissue and to treat cancer or nervous system disorders.

    摘要翻译： 描述了结合一种或多种EPH样受体，特别是HEK4受体的多肽。 多肽称为HEK4结合蛋白。 还描述了编码HEK4结合蛋白的核酸，以及用于产生多肽的表达载体，宿主细胞和方法。 多肽可用于调节多种组织的生长和/或分化，包括来自肝脏，肾脏，肺，皮肤，消化道和神经系统的组织的生长和/或分化，并可用于再生损伤或消耗的组织并治疗癌症或神经 系统障碍。

    Roller assembly apparatus and method of use
    6.
    发明授权
    Roller assembly apparatus and method of use 失效
    滚子总成装置及其使用方法

    公开(公告)号：US06860838B2

    公开(公告)日：2005-03-01

    申请号：US10209063

    申请日：2002-07-30

    申请人： Gary Fox

    发明人： Gary Fox

    IPC分类号： A63B22/02 ,  F16C13/00 ,  F16C13/02

    CPC分类号： F16C13/02 ,  A63B22/0235 ,  F16C13/00 ,  F16C2316/30

    摘要： The present invention relates in general to roller assembly apparatuses, and specifically to roller assembly apparatuses used in treadmills. An embodiment of the invention includes a roller apparatus, comprising: a shaft with raised surfaces on each end, a rotatable tube disposed around a portion of the shaft, and bearing assemblies. The bearing assemblies are disposed between the raised surfaces of the shaft and the rotatable tube such that the inner surfaces of the bearing assemblies contact the raised surfaces which allows the inner surfaces of the bearing assemblies to rotate on the raised surfaces, thus eliminating forces on the inner surfaces of the bearing assemblies.

    摘要翻译： 本发明一般涉及辊组装装置，具体涉及用于跑步机的辊组装装置。 本发明的一个实施例包括一种滚子装置，包括：一个在每一端具有凸起表面的轴，围绕该轴的一部分设置的可旋转管和轴承组件。 轴承组件设置在轴和可旋转管的凸起表面之间，使得轴承组件的内表面接触凸起表面，这允许轴承组件的内表面在凸起表面上旋转，从而消除了 轴承组件的内表面。

    DISTRIBUTING EVENTS BETWEEN AN INTEGRATED DEVELOPMENT ENVIRONMENT PROCESS AND ANOTHER PROCESS
    9.
    发明申请
    DISTRIBUTING EVENTS BETWEEN AN INTEGRATED DEVELOPMENT ENVIRONMENT PROCESS AND ANOTHER PROCESS 审中-公开
    集成开发环境过程和其他过程之间的分布式事件

    公开(公告)号：US20110247009A1

    公开(公告)日：2011-10-06

    申请号：US12753596

    申请日：2010-04-02

    申请人： Ken Dietrich ,  Gary Fox

    发明人： Ken Dietrich ,  Gary Fox

    IPC分类号： G06F9/46 ,  G06F3/00

    CPC分类号： G06F9/546

    摘要： A method for inter-process communications between an integrated development environment (IDE) process and a separate process. The IDE process and separate process are communicably coupled using an inter-process communication module that provides inter-process call channels for transporting messages between the IDE process and separate process, and adds a transport layer comprising routing information to the messages. A caller performs an action that raises an event that includes a requested operation to the IDE process, where the requested operation is only supported by the separate process. The IDE process sends a command message to the separate process using a first call channel that includes information for performing the requested operation. The requested operation is performed by the separate process. A return message is then sent by the separate process using a second call channel to the IDE process.

    摘要翻译： 集成开发环境（IDE）进程和单独进程之间的进程间通信的方法。 IDE进程和单独的进程可使用进程间通信模块进行可通信的耦合，该进程间通信模块提供用于在IDE进程和单独进程之间传送消息的进程间呼叫通道，并且将包括路由信息的传输层添加到消息中。 调用者执行一个操作，该操作将包含所请求的操作的事件引导到IDE进程，其中所请求的操作仅由单独的进程支持。 IDE进程使用包括用于执行请求的操作的信息的第一呼叫信道向单独进程发送命令消息。 请求的操作由单独的进程执行。 然后，单独进程使用第二个呼叫通道将返回消息发送到IDE进程。

    Method and apparatus for providing a standard control system with custom application capability
    10.
    发明申请
    Method and apparatus for providing a standard control system with custom application capability 有权
    用于提供具有定制应用能力的标准控制系统的方法和装置

    公开(公告)号：US20070038730A1

    公开(公告)日：2007-02-15

    申请号：US11204644

    申请日：2005-08-15

    申请人： Kenneth Dietrich ,  Gary Fox ,  Jethro Steinman ,  Jennifer O'Connell

    发明人： Kenneth Dietrich ,  Gary Fox ,  Jethro Steinman ,  Jennifer O'Connell

    IPC分类号： G06F15/177

    CPC分类号： G05B15/02

    摘要： A system and method for managing the activities of a process. The system includes a first computer that uses standard control classes to manage the activities according to a standard control strategy. A second computer is used by a user to input custom data. A custom application program uses the custom data to automatically develop a customized control strategy as a custom class that operates as an inherited class of a base class of the standard classes to augment the standard control strategy with the customized control strategy in the management of the activities.

    摘要翻译： 一种用于管理进程活动的系统和方法。 该系统包括使用标准控制类别的第一台计算机，以根据标准控制策略来管理活动。 用户使用第二台计算机来输入自定义数据。 自定义应用程序使用自定义数据自动开发定制控制策略作为自定义类，作为标准类的基类的继承类来运行，以便在管理活动时使用自定义控制策略来扩展标准控制策略 。