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公开(公告)号:US07935715B2
公开(公告)日:2011-05-03
申请号:US11781336
申请日:2007-07-23
申请人: Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David S. Thomson , Monika Ermann , James Edward Jenkins , Innocent Mushi , Malcolm Taylor , Christopher Francis Palmer , Nigel Blumire
发明人: Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David S. Thomson , Monika Ermann , James Edward Jenkins , Innocent Mushi , Malcolm Taylor , Christopher Francis Palmer , Nigel Blumire
IPC分类号: C07D213/75 , C07D403/12 , A61K31/44 , A61P29/00 , A61P37/00 , C07C317/44 , C07C215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D405/12 , C07D407/12
CPC分类号: C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要: Compound of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 公开了式(I)的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号:US08299111B2
公开(公告)日:2012-10-30
申请号:US12956322
申请日:2010-11-30
申请人: Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David S. Thomson , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Nigel Blumire
发明人: Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David S. Thomson , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Nigel Blumire
IPC分类号: A61K31/415 , C07D231/10
CPC分类号: C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 公开了式(I)的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号:US08829034B2
公开(公告)日:2014-09-09
申请号:US13022866
申请日:2011-02-08
申请人: Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David Thomson , Renee M. Zindell , Nigel Blumire , Chandana Parke , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Malcolm Taylor
发明人: Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David Thomson , Renee M. Zindell , Nigel Blumire , Chandana Parke , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Malcolm Taylor
IPC分类号: C07D409/04 , C07D309/02 , A61K31/351 , A61K31/42 , C07D261/12 , C07D217/22 , C07D277/82 , C07D309/04 , C07D277/46 , C07C317/44 , C07D213/75 , C07D417/12 , C07D407/12 , C07D405/12 , C07D413/12 , C07D215/38 , C07D403/12 , C07D231/40
CPC分类号: C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 公开了式(I)的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号:US07928123B2
公开(公告)日:2011-04-19
申请号:US11854607
申请日:2007-09-13
申请人: Angela Berry , Pier Francesco Cirillo , Doris Riether , David Thomson , Renee M. Zindell , Nigel Blumire , Chandana Chowdhury , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Malcolm Taylor
发明人: Angela Berry , Pier Francesco Cirillo , Doris Riether , David Thomson , Renee M. Zindell , Nigel Blumire , Chandana Chowdhury , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Malcolm Taylor
IPC分类号: C07D213/02 , A61K31/44
CPC分类号: C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 公开了式(I)的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号:US20080081822A1
公开(公告)日:2008-04-03
申请号:US11854607
申请日:2007-09-13
申请人: Angela Berry , Pier Cirillo , Eugene Hickey , Doris Riether , David Thomson , Renee Zindell , Nigel Blumire , Chandana Chowdhury , Monika Ermann , James Jenkins , Innocent Mushi , Christopher Palmer , Malcolm Taylor
发明人: Angela Berry , Pier Cirillo , Eugene Hickey , Doris Riether , David Thomson , Renee Zindell , Nigel Blumire , Chandana Chowdhury , Monika Ermann , James Jenkins , Innocent Mushi , Christopher Palmer , Malcolm Taylor
IPC分类号: A61K31/47 , A61K31/35 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61P11/00 , A61P19/00 , A61P29/00 , C07D249/08 , C07D231/10 , C07D221/00 , C07D215/00 , C07D213/02 , A61P9/00 , A61P43/00 , A61P37/00 , A61P35/00 , C07D309/02 , C07D285/12 , C07D285/08 , C07D277/20 , C07D263/54 , C07D261/06 , A61P25/00 , A61P17/00 , A61P1/00 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/4523
CPC分类号: C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 公开了式(I)的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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6.Therapeutic uses of compounds which selectively modulate the CB2 receptor 有权
标题翻译: 选择性调节CB2受体的化合物的治疗用途公开(公告)号:US08349871B2
公开(公告)日:2013-01-08
申请号:US13238054
申请日:2011-09-21
申请人: Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
发明人: Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
IPC分类号: A61K31/454 , A61K31/4196 , A61K31/422 , A61K31/42 , A61K31/427 , C07D401/12 , C07D285/135 , C07D261/14 , C07D249/14 , C07D277/46 , C07D277/62
CPC分类号: C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 公开了式(I)的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号:US08362039B2
公开(公告)日:2013-01-29
申请号:US13217480
申请日:2011-08-25
申请人: Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Markus Ostermeier , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
发明人: Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Markus Ostermeier , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
IPC分类号: A61K31/4525 , A61K31/4196 , A61K31/422 , A61K31/433
CPC分类号: C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
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公开(公告)号:US08048899B2
公开(公告)日:2011-11-01
申请号:US12564132
申请日:2009-09-22
申请人: Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Markus Ostermeier , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
发明人: Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Markus Ostermeier , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
IPC分类号: A61K31/433 , A61K31/42 , A61K31/422 , A61K31/4196 , C07D285/135 , C07D413/12 , C07D261/14 , C07D249/16
CPC分类号: C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要: are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 被披露。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号:US09315454B2
公开(公告)日:2016-04-19
申请号:US13521246
申请日:2011-01-11
申请人: Alessandra Bartolozzi , Angela Berry , Doris Riether , Monika Ermann , James Edward Jenkins , Innocent Mushi
发明人: Alessandra Bartolozzi , Angela Berry , Doris Riether , Monika Ermann , James Edward Jenkins , Innocent Mushi
IPC分类号: C07C317/06 , A61K31/165 , C07C323/41 , C07C317/44 , C07D211/54 , C07D213/40 , C07D261/08 , C07D265/30 , C07D295/185 , C07D295/205 , C07D309/04 , C07D333/20 , C07D333/38 , C07D413/12
CPC分类号: C07C323/41 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/54 , C07D213/40 , C07D261/08 , C07D265/30 , C07D295/185 , C07D295/205 , C07D309/04 , C07D333/20 , C07D333/38 , C07D413/12
摘要: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 公开了式(I)的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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公开(公告)号:US20120316173A1
公开(公告)日:2012-12-13
申请号:US13521246
申请日:2011-01-11
申请人: Alessandra Bartolozzi , Angela Berry , Doris Riether , Monika Ermann , James Edward Jenkins , Innocent Mushi
发明人: Alessandra Bartolozzi , Angela Berry , Doris Riether , Monika Ermann , James Edward Jenkins , Innocent Mushi
IPC分类号: A61K31/164 , A61K31/165 , C07D333/20 , A61K31/381 , C07D295/192 , A61K31/495 , C07D295/205 , C07D265/30 , A61K31/5375 , C07D211/54 , A61K31/445 , C07D409/06 , A61K31/496 , C07D309/06 , A61K31/351 , C07D261/08 , A61K31/422 , A61K31/42 , C07D413/12 , A61P37/06 , A61P9/10 , A61P37/08 , A61P17/00 , A61P13/12 , A61P11/04 , A61P29/00 , A61P25/06 , C07C317/44
CPC分类号: C07C323/41 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/54 , C07D213/40 , C07D261/08 , C07D265/30 , C07D295/185 , C07D295/205 , C07D309/04 , C07D333/20 , C07D333/38 , C07D413/12
摘要: Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译: 公开了式(I)的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂,拮抗剂或反向激动剂,并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
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