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1.发明授权公开(公告)号：US08491883B2
公开(公告)日：2013-07-23
申请号：US13026995
申请日：2011-02-14
CPC分类号： C12N5/0605 , A61K35/12 , C12N5/0607 , C12N5/0622 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/13 , C12N2501/21 , C12N2501/23 , C12N2501/385 , C12N2501/41 , C12N2502/02 , C12N2502/03 , C12N2506/02 , C12N2506/025 , C12N2506/03 , C12N2509/00 , C12N2533/50
摘要： This invention relates to methods of treating amyotrophic lateral sclerosis. In particular, the invention provides for methods of treating amyotrophic lateral sclerosis by administering umbilical cord tissue-derived cells, an effective amount of a substantially homogenous population of umbilical cord tissue-derived cells or a pharmaceutical composition comprising umbilical cord tissue-derived cells to a patient.
摘要翻译： 本发明涉及治疗肌萎缩性侧索硬化症的方法。 特别地，本发明提供了通过施用脐带组织来源的细胞，有效量的基本上均匀的脐带组织来源的细胞群或包含脐带组织来源的细胞的药物组合物来治疗肌萎缩性侧索硬化的方法 患者。
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公开(公告)号：US11191789B2
公开(公告)日：2021-12-07
申请号：US10876998
申请日：2004-06-25
申请人： Anthony J. Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander M. Harmon , Ian Ross Harris , Darin J. Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
发明人： Anthony J. Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander M. Harmon , Ian Ross Harris , Darin J. Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
IPC分类号： A61K48/00 , A61K35/51 , C12N5/074 , C12N5/073 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/27 , C12N5/0735 , A61K35/50 , A61K35/12
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
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3.发明授权公开(公告)号：US09498501B2
公开(公告)日：2016-11-22
申请号：US12389305
申请日：2009-02-19
申请人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
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4.发明授权Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 有权来自脐带组织的产后细胞，以及制造和使用它们的方法公开(公告)号：US08318483B2
公开(公告)日：2012-11-27
申请号：US11481456
申请日：2006-07-06
申请人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Anna Gosiewska
IPC分类号： C12N5/00
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。
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5.发明授权Postpartum cells derived from placental tissue, and methods of making and using the same 有权来自胎盘组织的产后细胞，以及制造和使用胎盘组织的方法公开(公告)号：US09579351B2
公开(公告)日：2017-02-28
申请号：US10877446
申请日：2004-06-25
申请人： Anthony J. Kihm , Ian Ross Harris , Sanjay Mistry , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Anthony J. Kihm , Ian Ross Harris , Sanjay Mistry , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
摘要翻译： 由产后胎盘衍生的细胞及其分离方法由本发明提供。 本发明还提供了胎盘衍生细胞的培养物和组合物。 本发明的胎盘衍生细胞具有许多用途，包括但不限于研究，诊断和治疗应用。
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6.发明授权公开(公告)号：US08658152B2
公开(公告)日：2014-02-25
申请号：US13605716
申请日：2012-09-06
申请人： Darin J. Messina , Alexander M. Harmon , Ian R. Harris , Anthony J. Kihm , Sanjay Mistry , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Darin J. Messina , Alexander M. Harmon , Ian R. Harris , Anthony J. Kihm , Sanjay Mistry , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞进行神经组织再生或修复的药物组合物，装置和方法。
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7.发明申请REGENERATION AND REPAIR OF NEURAL TISSUE USING POSTPARTUM-DERIVED CELLS 有权使用POSTPART-DERIVED细胞再生和修复神经组织公开(公告)号：US20100260843A1
公开(公告)日：2010-10-14
申请号：US12429849
申请日：2009-04-24
申请人： Darin J. Messina , Sanjay Mistry , Alexander M. Harmon , Ian Ross Harris , Anthony J. Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Darin J. Messina , Sanjay Mistry , Alexander M. Harmon , Ian Ross Harris , Anthony J. Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞进行神经组织再生或修复的药物组合物，装置和方法。
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8.发明授权Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same 有权从脐带组织分离的产后细胞，以及制造和使用它们的方法公开(公告)号：US07510873B2
公开(公告)日：2009-03-31
申请号：US10877012
申请日：2004-06-25
申请人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。
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公开(公告)号：US09102915B2
公开(公告)日：2015-08-11
申请号：US11939360
申请日：2007-11-13
CPC分类号： C12N5/0607 , C12M25/16 , C12N5/0605 , C12N2531/00 , C12N2533/52 , C12N2533/54
摘要： Compositions and methods for the growth and expansion of mammalian cells in culture are provided. In particular, methods for the growth and expansion of postpartum-derived cells in vitro are provided using surfaces such as microcarrier beads.
摘要翻译： 提供了培养中哺乳动物细胞生长和扩增的组合物和方法。 特别地，使用诸如微载体珠的表面提供体外产生产生细胞的生长和扩增的方法。
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10.发明授权Postpartum-derived cells for use in treatment of disease of the heart and circulatory system 有权产后来源的细胞用于治疗心脏和循环系统疾病公开(公告)号：US08703121B2
公开(公告)日：2014-04-22
申请号：US10877445
申请日：2004-06-25
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue and methods for their use in treatment of diseases of the heart or circulatory system are disclosed. Cells may be used in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors.
摘要翻译： 公开了源自产后组织的细胞及其用于治疗心脏或循环系统疾病的方法。 细胞可以以分化或未分化的形式，均匀培养物或与其他细胞群体一起使用，并与其它生物活性因子结合使用。
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