公开(公告)号：US20100267822A1

公开(公告)日：2010-10-21

申请号：US12749024

申请日：2010-03-29

申请人： Annie George D/O V.K. George ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Joachim Hans ,  Joerg Gruenwald ,  Matthias Gehling ,  Philipp Wabnitz ,  Tengku Shahrir bin Tengku Adnan ,  Torsten Grothe

发明人： Annie George D/O V.K. George ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Joachim Hans ,  Joerg Gruenwald ,  Matthias Gehling ,  Philipp Wabnitz ,  Tengku Shahrir bin Tengku Adnan ,  Torsten Grothe

IPC分类号： A61K31/343 ,  C07D307/83 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  A61P27/02 ,  A61P9/12 ,  A61P19/08 ,  A61P35/00 ,  A61P9/00 ,  A61P15/00 ,  A61P5/30

CPC分类号： C07D307/83 ,  C07D407/04

摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with an estrogen receptor (ER) related disease or condition of the animal or human body, as well as methods, uses and other inventions related thereto.

摘要翻译： 本发明涉及包含它们可用于预防和/或治疗具有雌激素受体（ER）相关疾病或动物或人体的病症的动物（包括人））的赭色和提取物以及方法，用途 和其他有关的发明。

公开(公告)号：US10047034B2

公开(公告)日：2018-08-14

申请号：US14401699

申请日：2013-05-07

申请人： Joachim Hans ,  Torsten Grothe

发明人： Joachim Hans ,  Kathrin Reinhardt ,  Torsten Grothe ,  Ingo Wöhrle ,  Jana Moldenhauer ,  Bärbel Köpcke ,  Thomas Küper ,  Jens Bitzer

IPC分类号： A01N37/00 ,  A61K31/19 ,  C07C62/32 ,  A61K45/06 ,  A61K31/01 ,  A61K31/015 ,  A61K31/191 ,  A61K31/192 ,  A61K31/352 ,  A61K31/7048 ,  A61K36/73 ,  A61K9/46 ,  A61K47/26 ,  A61K47/46 ,  A61K9/20 ,  A61K9/48 ,  A23C9/13 ,  A23C9/133 ,  A23C9/156 ,  A23C11/02 ,  A23C15/16 ,  A23L2/39 ,  A23L2/40 ,  A23L2/52 ,  A23G9/32 ,  A21D2/16 ,  A21D2/36 ,  A21D8/04 ,  A23D7/005 ,  A23L7/126 ,  A23L27/10 ,  A23L27/60 ,  A23L33/105 ,  A61K9/00

摘要： The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.

公开(公告)号：US20150133552A1

公开(公告)日：2015-05-14

申请号：US14401699

申请日：2013-05-07

申请人： Torsten Grothe ,  Joachim HANS

发明人： Joachim Hans ,  Kathrin Reinhardt ,  Torsten Grothe ,  Ingo Wöhrle ,  Jana Moldenhauer ,  Bärbel Köpcke ,  Thomas Küper ,  Jens Bitzer

IPC分类号： C07C62/32 ,  A61K45/06 ,  A61K31/191

CPC分类号： C07C62/32 ,  A21D2/165 ,  A21D2/36 ,  A21D8/047 ,  A23C9/1315 ,  A23C9/1322 ,  A23C9/133 ,  A23C9/156 ,  A23C9/1565 ,  A23C11/02 ,  A23C15/16 ,  A23C2260/152 ,  A23D7/0056 ,  A23G9/32 ,  A23L2/39 ,  A23L2/40 ,  A23L2/52 ,  A23L7/126 ,  A23L27/10 ,  A23L27/60 ,  A23L33/105 ,  A61K9/0007 ,  A61K9/0095 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/485 ,  A61K9/4866 ,  A61K9/4891 ,  A61K31/01 ,  A61K31/015 ,  A61K31/191 ,  A61K31/192 ,  A61K31/352 ,  A61K31/7048 ,  A61K36/73 ,  A61K45/06 ,  A61K47/26 ,  A61K47/46 ,  A61K2300/00

摘要： The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.

摘要翻译： 本发明涉及用于预防和/或治疗治疗对HMG-CoA还原酶活性降低的疾病，病症或病症的式（I）的某些多羟基化五环三萜酸，其用作HMG-CoA还原酶抑制剂 在哺乳动物中，优选人。 本发明进一步涉及某些混合物和植物提取物，其中含有苹果酸和折酮酸，其中欧托卡酸与折羟酸的量超过一定比例。 此外，本发明还涉及包含一种或多种所述式（I）化合物，根据本发明的组合物或根据本发明的植物提取物的制剂，优选药物或营养制剂。 此外，本发明涉及一种获得式（I）的某些多羟基化五环三萜酸，根据本发明的组合物或根据本发明的植物提取物的方法。