公开(公告)号：US09347931B2

公开(公告)日：2016-05-24

申请号：US13265813

申请日：2010-04-23

申请人： Anthony Joseph Killard ,  Magdalena Maria Dudek ,  Brian MacCraith ,  Ib Mendel-Hartvig ,  Ove Öhman

发明人： Anthony Joseph Killard ,  Magdalena Maria Dudek ,  Brian MacCraith ,  Ib Mendel-Hartvig ,  Ove Öhman

IPC分类号： G01N33/00 ,  G01N33/49 ,  G01N33/543 ,  G01N33/545 ,  G01N33/558 ,  G01N33/86 ,  B01L3/00

CPC分类号： G01N33/4905 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54353 ,  G01N33/545 ,  G01N33/558 ,  G01N33/86

摘要： The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.

摘要翻译： 本发明涉及一种用于监测和测量凝血的侧流测定装置及其方法。 理想地，本发明涉及用于监测和/或测量液体样品中的凝结的侧向毛细管流动装置，其中该装置包括具有用于接收样品的区域和限定的流动路径区域的无孔基材，其中凝固 试剂沉积在限定的流动路径区的至少部分上以加速液体样品的凝结，使得能够沿着限定的流动路径区形成均匀分布的凝块，并导致流速的变化或流动停止 液体样品沿着限定的流路区域。

公开(公告)号：US20120107851A1

公开(公告)日：2012-05-03

申请号：US13265813

申请日：2010-04-23

申请人： Anthony Joseph Killard ,  Magdalena Maria Dudek ,  Brian MacCraith ,  Ib Mendel-Hartvig ,  Ove Öhman

发明人： Anthony Joseph Killard ,  Magdalena Maria Dudek ,  Brian MacCraith ,  Ib Mendel-Hartvig ,  Ove Öhman

IPC分类号： C12Q1/56 ,  B05D3/04 ,  G01N33/86 ,  G01N33/68 ,  C12M1/40

CPC分类号： G01N33/4905 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54353 ,  G01N33/545 ,  G01N33/558 ,  G01N33/86

摘要： The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.

摘要翻译： 本发明涉及一种用于监测和测量凝血的侧流测定装置及其方法。 理想地，本发明涉及用于监测和/或测量液体样品中的凝结的侧向毛细管流动装置，其中该装置包括具有用于接收样品的区域和限定的流动路径区域的无孔基材，其中凝固 试剂沉积在限定的流动路径区的至少部分上以加速液体样品的凝结，使得能够沿着限定的流动路径区形成均匀分布的凝块，并导致流速的变化或流动停止 液体样品沿着限定的流路区域。

公开(公告)号：US20060257094A1

公开(公告)日：2006-11-16

申请号：US10547065

申请日：2004-02-27

申请人： Aisling McEvoy ,  Brian MacCraith ,  Colette McDonagh ,  Christoph Von Bultzingslowen ,  Olive Von Bultzingslowen

发明人： Aisling McEvoy ,  Brian MacCraith ,  Colette McDonagh ,  Christoph Von Bultzingslowen ,  Olive Von Bultzingslowen

IPC分类号： G02B6/00

CPC分类号： G01N21/643 ,  G01N21/6408 ,  G01N21/77 ,  G01N21/80 ,  G01N2021/773

摘要： Improved carbon dioxide sensors are disclosed which are less sensitive to the moisture content of the environment and which are substantially insensitive to oxygen levels under normal working conditions. The CO2 sensor comprises a pH indicator and long-lived reference luminophore and a porous sol-gel matrix. Combined CO2 and O2sensors are also described. Further disclose are methods of printing sensor onto substrates.

摘要翻译： 公开了改进的二氧化碳传感器，其对环境的水分含量较不敏感，并且在正常工作条件下对氧水平基本不敏感。 CO 2传感器包括pH指示剂和长寿命参考发光体和多孔溶胶 - 凝胶基质。 还描述了组合CO 2 2和O 2传感器。 进一步公开的是将传感器打印到基底上的方法。

公开(公告)号：US20140296112A1

公开(公告)日：2014-10-02

申请号：US14343612

申请日：2011-09-09

申请人： Stephen O'Driscoll ,  Conor Burke ,  Brian MacCraith

发明人： Stephen O'Driscoll ,  Conor Burke ,  Brian MacCraith

IPC分类号： G01N33/543 ,  G01J1/58 ,  G01N21/64

CPC分类号： G01N33/54373 ,  G01J1/58 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/28 ,  G01J3/4406 ,  G01J3/50 ,  G01J2003/1213 ,  G01N21/251 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6486 ,  G01N21/8483 ,  G01N33/487 ,  G01N33/497 ,  G01N2021/6432 ,  G01N2021/7786 ,  G01N2201/0221 ,  G01N2201/024

摘要： The present application provides a system (1) that comprises a mobile phone (25) to allow testing of samples from a patient at the point of care or environmental/industrial process monitoring tests to be performed in the field. The system (1) may be easily adapted for use with a variety of different mobile phones (25). The mobile phone (25) comprises an integrated camera (15). The system (1) further comprises an optical module (20) for receiving a sample for testing. The mobile phone (25) is configured to extract the intensity and/or colour information from the camera (15).

摘要翻译： 本申请提供了一种系统（1），其包括移动电话（25），以允许在现场执行护理点或环境/工业过程监视测试时从患者测试样本。 系统（1）可以容易地适用于各种不同的移动电话（25）。 移动电话（25）包括集成照相机（15）。 系统（1）还包括用于接收用于测试的样本的光学模块（20）。 移动电话（25）被配置为从相机（15）提取强度和/或颜色信息。

公开(公告)号：US20130236982A1

公开(公告)日：2013-09-12

申请号：US13697278

申请日：2011-05-11

申请人： Jim Writser Peter Bakker ,  Ove Ohman ,  Dirk Kurzbuch ,  Thomas Ruckstuhl ,  Brian MacCraith ,  Stephen O'Driscoll

发明人： Jim Writser Peter Bakker ,  Ove Ohman ,  Dirk Kurzbuch ,  Thomas Ruckstuhl ,  Brian MacCraith ,  Stephen O'Driscoll

IPC分类号： G01N21/64 ,  G01N21/76 ,  G01N21/66

CPC分类号： G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/66 ,  G01N21/76 ,  G01N33/54373

摘要： A sensor comprising a substrate (100) having a first surface (105) and a second surface (110) is described. The first surface has at least one sensor site (115) provided thereon. The substrate is configured such that on excitation of a sample provided at the sensor site, luminescence originating from the sensor site propagates into the substrate, the second surface of the substrate being configured to selectively transmit the luminescence propagating within the substrates at angles greater than the critical angle out of the substrate where it may be detected by a detector (160) provided below the substrate.

摘要翻译： 描述了包括具有第一表面（105）和第二表面（110）的基底（100）的传感器。 第一表面具有设置在其上的至少一个传感器部位（115）。 衬底被配置为使得在激发提供在传感器位置处的样品时，源自传感器位置的发光传播到衬底中，衬底的第二表面被配置为选择性地将在衬底内传播的发光以大于 衬底外的临界角，其可以由设置在衬底下方的检测器（160）检测。

公开(公告)号：US09291558B2

公开(公告)日：2016-03-22

申请号：US13697278

申请日：2011-05-11

申请人： Jim Writser Peter Bakker ,  Ove Ohman ,  Dirk Kurzbuch ,  Thomas Ruckstuhl ,  Brian MacCraith ,  Stephen O'Driscoll

发明人： Jim Writser Peter Bakker ,  Ove Ohman ,  Dirk Kurzbuch ,  Thomas Ruckstuhl ,  Brian MacCraith ,  Stephen O'Driscoll

IPC分类号： G01N21/76 ,  G01N21/64 ,  G01N33/543 ,  G01N21/66

CPC分类号： G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/66 ,  G01N21/76 ,  G01N33/54373

摘要： A sensor comprising a substrate (100) having a first surface (105) and a second surface (110) is described. The first surface has at least one sensor site (115) provided thereon. The substrate is configured such that on excitation of a sample provided at the sensor site, luminescence originating from the sensor site propagates into the substrate, the second surface of the substrate being configured to selectively transmit the luminescence propagating within the substrates at angles greater than the critical angle out of the substrate where it may be detected by a detector (160) provided below the substrate.

摘要翻译： 描述了包括具有第一表面（105）和第二表面（110）的基底（100）的传感器。 第一表面具有设置在其上的至少一个传感器部位（115）。 衬底被配置为使得在激发提供在传感器位置处的样品时，源自传感器位置的发光传播到衬底中，衬底的第二表面被配置为选择性地将在衬底内传播的发光以大于 衬底外的临界角，其可以由设置在衬底下方的检测器（160）检测。

公开(公告)号：US20050009198A1

公开(公告)日：2005-01-13

申请号：US10489268

申请日：2002-09-11

申请人： Brian MacCraith ,  Lubos Polerecky

发明人： Brian MacCraith ,  Lubos Polerecky

IPC分类号： G01N21/64 ,  G01N33/543

CPC分类号： G01N21/648 ,  G01N21/6428 ,  G01N33/54373

摘要： A luminescence-based sensor assembly is described. The sensor assembly utilizes the angular propagation of light into a substrate to distinguish between light originating from a luminescent source close to the substrate and that from a source further away from the substrate. Utilizing such a technique, it is possible to employ direct illumination of the sources of luminescence.

摘要翻译： 描述基于发光的传感器组件。 传感器组件利用光到衬底中的角度传播来区分源于靠近衬底的发光源的光和来自远离衬底的源的光。 利用这种技术，可以直接照射发光源。

公开(公告)号：US09244066B2

公开(公告)日：2016-01-26

申请号：US14343612

申请日：2011-09-09

申请人： Stephen O'Driscoll ,  Conor Burke ,  Brian MacCraith

发明人： Stephen O'Driscoll ,  Conor Burke ,  Brian MacCraith

IPC分类号： G01N33/50 ,  G01N21/77 ,  G01N21/64 ,  G01J1/58 ,  G01N33/543 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44 ,  G01J3/50 ,  G01N21/25 ,  G01J3/12 ,  G01N21/84

CPC分类号： G01N33/54373 ,  G01J1/58 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/28 ,  G01J3/4406 ,  G01J3/50 ,  G01J2003/1213 ,  G01N21/251 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6486 ,  G01N21/8483 ,  G01N33/487 ,  G01N33/497 ,  G01N2021/6432 ,  G01N2021/7786 ,  G01N2201/0221 ,  G01N2201/024

摘要： The present application provides a system (1) that comprises a mobile phone (25) to allow testing of samples from a patient at the point of care or environmental/industrial process monitoring tests to be performed in the field. The system (1) may be easily adapted for use with a variety of different mobile phones (25). The mobile phone (25) comprises an integrated camera (15). The system (1) further comprises an optical module (20) for receiving a sample for testing. The mobile phone (25) is configured to extract the intensity and/or color information from the camera (15).

摘要翻译： 本申请提供了一种系统（1），其包括移动电话（25），以允许在现场执行护理点或环境/工业过程监视测试时从患者测试样本。 系统（1）可以容易地适用于各种不同的移动电话（25）。 移动电话（25）包括集成照相机（15）。 系统（1）还包括用于接收用于测试的样本的光学模块（20）。 移动电话（25）被配置为从相机（15）提取强度和/或颜色信息。

公开(公告)号：US07750316B2

公开(公告)日：2010-07-06

申请号：US11431349

申请日：2006-05-10

申请人： Brian MacCraith ,  Thomas Ruckstuhl

发明人： Brian MacCraith ,  Thomas Ruckstuhl

IPC分类号： G01N21/64

CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N2021/6463

摘要： This present disclosure provides an optical chip for fluorescence detection. The optical chip has one or more parabolic optical elements that capture and collimate the fluorescent light and direct it onto a detector. The optical chip may be constructed of a polymer and made using injection molding techniques.

摘要翻译： 本公开提供了一种用于荧光检测的光学芯片。 光学芯片具有一个或多个抛物面光学元件，其捕获并准直荧光并将其引导到检测器上。 光学芯片可以由聚合物构成，并使用注射成型技术制成。

公开(公告)号：US07655475B2

公开(公告)日：2010-02-02

申请号：US10470133

申请日：2002-01-23

申请人： Brian MacCraith ,  Lubos Polerecky

发明人： Brian MacCraith ,  Lubos Polerecky

IPC分类号： G01N21/64

CPC分类号： G01N21/6452 ,  G01N2021/6463 ,  G01N2021/6478

摘要： The invention provides a luminescent based sensor having a luminescent material optically coupled to a substrate, and adapted to be used in a medium or environment such as water or air. A detector is provided to detect light that is emitted into the substrate by the material. The substrate is adapted to redirect light that is emitted into the substrate at angles with the range θesc ? θ ? θlsc where θesc is the critical angle of the environment/substrate interface and θlsc is the critical angle of the luminescent layer/substrate interface. Examples of possible configurations are described.

摘要翻译： 本发明提供了一种发光基传感器，其具有光学耦合到基底的发光材料，并且适于在诸如水或空气的介质或环境中使用。 提供检测器以检测由材料发射到衬底中的光。 衬底适合于将发射到衬底中的光以与θesc θ 其中thetaesc是环境/衬底界面的临界角，而tanδ是发光层/衬底界面的临界角。 描述可能的配置的示例。