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    Assay device and method
    1.
    发明授权
    Assay device and method 有权
    测定装置和方法

    公开(公告)号：US08877142B2

    公开(公告)日：2014-11-04

    申请号：US12305630

    申请日：2007-06-20

    申请人： Per Ove Öhman ,  Ib Mendel-Hartvig

    发明人： Per Ove Öhman ,  Ib Mendel-Hartvig

    IPC分类号： B01L3/00 ,  G01N33/52 ,  G01N33/558 ,  G01N35/00

    CPC分类号： G01N33/5304 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0896 ,  B01L2400/0406 ,  B01L2400/086 ,  B01L2400/088 ,  G01N33/525 ,  G01N33/558 ,  G01N2035/00237 ,  Y10T436/25

    摘要： There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.

    摘要翻译： 提供了一种包括盖和基底的测定装置，所述基底包括样品加入区，反应区和吸收区，所述组分处于流体连接状态，并且是从样品添加区引导至流体通道的一部分 所述吸收区，其中：（a）样品添加井被整合在所述盖中，（b）所述吸收区由无孔基底上的区域组成，具有基本上垂直的突起，所述突起限定体积， 流体通道的体积限定经过测定的样品体积，和（c）至少一个过滤器位于样品加入孔和样品添加区之间。 还提供了处理样品的方法。

    Micro fluidic structures
    2.
    发明授权
    Micro fluidic structures 有权
    微流体结构

    公开(公告)号：US08025854B2

    公开(公告)日：2011-09-27

    申请号：US10492453

    申请日：2003-06-04

    申请人： Ove Ohman ,  Ib Mendel-Hartvig

    发明人： Ove Ohman ,  Ib Mendel-Hartvig

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N30/6065 ,  G01N30/6095 ,  G01N2030/525 ,  Y10T436/25

    摘要： The invention relates to a micro fluidic system comprising a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.

    摘要翻译： 本发明涉及一种微流体系统，其包括衬底，并且在所述衬底上提供与功能装置相互连接的至少一个流路，其中可以通过期望的程序处理液体样品。 布置流动路径以形成用于将液体样品运送到所述功能装置和从所述功能装置输送液体样品的图案。 这些流动路径包括从所述基底向上突出的多个微柱，微柱之间的间隔足够小，以在任何一个所述流动路径内的任何地方施加液体样品中的毛细管作用，以迫使所述液体移动 从其中应用所述液体样品。

    ASSAY DEVICE
    3.
    发明申请
    ASSAY DEVICE 有权
    测定装置

    公开(公告)号：US20100041154A1

    公开(公告)日：2010-02-18

    申请号：US12305641

    申请日：2007-06-20

    申请人： Per Ove Öhman ,  Ib Mendel-Hartvig ,  Tomas Lindström

    发明人： Per Ove Öhman ,  Ib Mendel-Hartvig ,  Tomas Lindström

    IPC分类号： G01N33/558 ,  G01N33/00

    CPC分类号： G01N33/543 ,  B01L3/502746 ,  B01L2200/025 ,  B01L2300/025 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/089 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/558 ,  Y10S436/807 ,  Y10T436/10 ,  Y10T436/13

    摘要： The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone. There is further provided a kit of parts and a method of conducting an assay.

    摘要翻译： 本发明提供了一种用于使用能够结合抗原并含有标签的检测结合物对液体样品进行测定的测定装置，所述装置包括具有基底表面的基底，其中所述表面包括基本垂直于所述表面的突起 所述突起具有能够在所述通道中产生流体的侧向毛细管流动的高度，直径和距离，所述表面包括样品添加区，反应区和吸收区，所述区通过至少一个流体通道连接， 其中所述装置具有位于样品添加区域和反应区域之间的第一功能验证特征，以及位于吸收区域内的第二功能验证特征，并且两个功能性验证特征是当被样品接触时能够经受可检测变化的特征 ，所述测定装置还包括至少一个对准验证码 定位区。 还提供了一组试剂盒和进行测定的方法。

    Optical assay system
    4.
    发明授权
    Optical assay system 有权
    光学测定系统

    公开(公告)号：US07564045B2

    公开(公告)日：2009-07-21

    申请号：US11454993

    申请日：2006-06-15

    申请人： Per Ove Ohman ,  Tomas Lindstrom ,  Ib Mendel-Hartvig

    发明人： Per Ove Ohman ,  Tomas Lindstrom ,  Ib Mendel-Hartvig

    IPC分类号： G01N21/64

    CPC分类号： G01N21/648 ,  B01L3/502746 ,  B01L2300/0654 ,  B01L2300/0822 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G02B6/2852

    摘要： An optical reader for an optical assay arrangement including a polymeric sample substrate having a reaction-site surface provided with protruding microstructures and at least one reaction-site area; a light source for illuminating the reaction-site area; and a detector device for detecting light emitted from the reaction-site area. The light source is arranged to inject exciting light rays into the polymeric sample substrate with a controlled angle of incidence such that the protruding microstructures guide the exciting light rays in the direction of the reaction-site area, and the detector device detects light emitted from the at least one reaction-site area.

    摘要翻译： 一种用于光学测定装置的光学读取器，其包括聚合物样品基底，其具有设置有突出微结构的反应位点表面和至少一个反应位点区域; 用于照亮反应部位区域的光源; 以及用于检测从反应部位区域发射的光的检测器装置。 光源设置成以可控的入射角将激发的光线注入到聚合物样品基底中，使得突出的微结构在反应位置区域的方向上引导激发光线，并且检测器装置检测从 至少一个反应部位。

    Flourescence reader
    5.
    发明申请
    Flourescence reader 有权
    荧光读物

    公开(公告)号：US20070231883A1

    公开(公告)日：2007-10-04

    申请号：US11726973

    申请日：2007-03-22

    申请人： Tomas Lindstrom ,  Ib Mendel-Hartvig ,  Ove Ohman ,  Johan Backlund ,  Kennet Vilhelmsson

    发明人： Tomas Lindstrom ,  Ib Mendel-Hartvig ,  Ove Ohman ,  Johan Backlund ,  Kennet Vilhelmsson

    IPC分类号： C12M1/34 ,  G01J3/427 ,  C12M3/00

    CPC分类号： G01N21/6428 ,  G01N21/645 ,  G01N2021/6465

    摘要： Fluorescence reader (10) for an optical assay arrangement comprising a polymeric sample substrate (1) having a reaction site-surface and a substrate surface (3), the fluorescence reader comprising a light source (5) arranged to illuminate the reaction site-surface through the substrate surface, and a detector device (6) arranged to detect fluorescent light emitted from said reaction site-surface and transmitted through the substrate surface, the substrate surface provided with total-internal-reflection suppressing means (15).

    摘要翻译： 用于光学测定装置的荧光读取器（10），包括具有反应位点表面和基底表面（3）的聚合物样品基底（1），所述荧光读取器包括光源（5），其被布置成照亮反应位点表面 以及检测器装置（6），其被配置为检测从所述反应位置表面发射并透过所述基板表面的荧光，所述基板表面设置有全内反射抑制装置（15）。

    Micro fluidic structures
    6.
    发明申请
    Micro fluidic structures 有权
    微流体结构

    公开(公告)号：US20050042766A1

    公开(公告)日：2005-02-24

    申请号：US10492453

    申请日：2003-06-04

    申请人： Ove Ohman ,  Ib Mendel-Hartvig

    发明人： Ove Ohman ,  Ib Mendel-Hartvig

    IPC分类号： G01N35/08 ,  B01J4/00 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  C12M1/00 ,  G01N30/52 ,  G01N30/60 ,  G01N37/00

    CPC分类号： B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N30/6065 ,  G01N30/6095 ,  G01N2030/525 ,  Y10T436/25

    摘要： The invention relates to a micro fluidic system comprising a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.

    摘要翻译： 本发明涉及一种微流体系统，其包括衬底，并且在所述衬底上提供与功能装置相互连接的至少一个流路，其中液体样品可以通过期望的程序进行处理。 布置流动路径以形成用于将液体样品运送到所述功能装置和从所述功能装置输送液体样品的图案。 这些流动路径包括从所述基底向上突出的多个微柱，微柱之间的间隔足够小，以在任何一个所述流动路径内的任何地方施加液体样品中的毛细管作用，以迫使所述液体移动 从其中应用所述液体样品。

    CONTROLLED FLOW ASSAY DEVICE AND METHOD
    9.
    发明申请
    CONTROLLED FLOW ASSAY DEVICE AND METHOD 有权
    控制流量测定装置及方法

    公开(公告)号：US20100248394A1

    公开(公告)日：2010-09-30

    申请号：US12796351

    申请日：2010-06-08

    申请人： Per Ove Ohman ,  Ib Mendel-Hartvig

    发明人： Per Ove Ohman ,  Ib Mendel-Hartvig

    IPC分类号： G01N33/543

    CPC分类号： B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0433 ,  B01L2400/0442 ,  B01L2400/086 ,  Y10T436/2575

    摘要： A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.

    摘要翻译： 一种用于处理液体样品的装置，包括具有用于接收样品的至少一个区域的流动路径，以及运输或孵化区域，所述区域由具有基本上垂直于其表面的突起的区域连接或包括具有突出部的区域，所述装置设置有水槽 具有接收所述液体样品的能力，所述水槽包括具有基本上垂直于其表面的突起的区域，并且所述水槽适于响应于调节其接收所述液体样品的能力的外部影响。

    Method and means for creating fluid transport
    10.
    发明申请
    Method and means for creating fluid transport 有权
    创造流体输送的方法和手段

    公开(公告)号：US20060285996A1

    公开(公告)日：2006-12-21

    申请号：US11471061

    申请日：2006-06-19

    申请人： Per Ohman ,  Ib Mendel-Hartvig

    发明人： Per Ohman ,  Ib Mendel-Hartvig

    IPC分类号： G01N31/22

    CPC分类号： B01L3/5025 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/086 ,  Y10T436/2575

    摘要： An absorbing zone for establishing and/or maintaining fluid transport through or along said at least one fluid passage is manufactured on the basis of a non-porous substrate, having projections substantially perpendicular to said surface, and said projections having a height, diameter and a distance or distances between the projections such, that lateral capillary flow of said fluid in said zone is achieved.

    摘要翻译： 用于建立和/或维持沿着所述至少一个流体通道的流体输送的吸收区域是基于具有基本上垂直于所述表面的突出物的无孔基材制造的，并且所述突起具有高度，直径和 突起之间的距离或距离，使得实现所述区域中的所述流体的侧向毛细管流动。